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Splenic Contraction

MedGen UID:
1779238
•Concept ID:
C5447229
•
Finding

Definition

The process by which the spleen becomes smaller in size or scope. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic Contraction

Professional guidelines

PubMed

Indication and management of allogeneic haematopoietic stem-cell transplantation in myelofibrosis: updated recommendations by the EBMT/ELN International Working Group.
Kröger N, Bacigalupo A, Barbui T, Ditschkowski M, Gagelmann N, Griesshammer M, Gupta V, Hamad N, Harrison C, Hernandez-Boluda JC, Koschmieder S, Jain T, Mascarenhas J, Mesa R, Popat UR, Passamonti F, Polverelli N, Rambaldi A, Robin M, Salit RB, Schroeder T, Scott BL, Tamari R, Tefferi A, Vannucchi AM, McLornan DP, Barosi G
Lancet Haematol 2024 Jan;11(1):e62-e74. Epub 2023 Dec 4 doi: 10.1016/S2352-3026(23)00305-8. PMID: 38061384
Thrombocytopenia in Patients With Myelofibrosis: Pathogenesis, Prevalence, Prognostic Impact, and Treatment.
Sastow D, Mascarenhas J, Tremblay D
Clin Lymphoma Myeloma Leuk 2022 Jul;22(7):e507-e520. Epub 2022 Feb 5 doi: 10.1016/j.clml.2022.01.016. PMID: 35221248
Next Generation Therapeutics for the Treatment of Myelofibrosis.
Tremblay D, Mascarenhas J
Cells 2021 Apr 27;10(5) doi: 10.3390/cells10051034. PMID: 33925695Free PMC Article

Recent clinical studies

Etiology

Pulsed Ultrasound of the Spleen Prolongs Survival of Rats With Severe Intra-abdominal Sepsis.
Zhang A, Charles EJ, Xing J, Sawyer RG, Yang Z
J Surg Res 2021 Mar;259:97-105. Epub 2020 Dec 3 doi: 10.1016/j.jss.2020.11.005. PMID: 33279849Free PMC Article
Post-stroke infections associated with spleen volume reduction: A pilot study.
Nous A, Peeters I, Nieboer K, Vanbinst AM, De Keyser J, De Raedt S
PLoS One 2020;15(5):e0232497. Epub 2020 May 11 doi: 10.1371/journal.pone.0232497. PMID: 32392257Free PMC Article
Breath-Hold Diving.
Fitz-Clarke JR
Compr Physiol 2018 Mar 25;8(2):585-630. doi: 10.1002/cphy.c160008. PMID: 29687909
Splenic contraction: a new member of the hypovolemic shock complex.
Enslow MS, Preece SR, Wildman-Tobriner B, Enslow RA, Mazurowski M, Nelson RC
Abdom Radiol (NY) 2018 Sep;43(9):2375-2383. doi: 10.1007/s00261-018-1478-3. PMID: 29460045
Acute splenic responses in patients with ischemic stroke and intracerebral hemorrhage.
Vahidy FS, Parsha KN, Rahbar MH, Lee M, Bui TT, Nguyen C, Barreto AD, Bambhroliya AB, Sahota P, Yang B, Aronowski J, Savitz SI
J Cereb Blood Flow Metab 2016 Jun;36(6):1012-21. Epub 2015 Oct 2 doi: 10.1177/0271678X15607880. PMID: 26661179Free PMC Article

Diagnosis

Post-stroke infections associated with spleen volume reduction: A pilot study.
Nous A, Peeters I, Nieboer K, Vanbinst AM, De Keyser J, De Raedt S
PLoS One 2020;15(5):e0232497. Epub 2020 May 11 doi: 10.1371/journal.pone.0232497. PMID: 32392257Free PMC Article
Spurious Hb mass increases following exercise.
Gough CE, Eastwood A, Saunders PU, Anson JM, Gore CJ
Int J Sports Med 2012 Sep;33(9):691-5. Epub 2012 Jun 15 doi: 10.1055/s-0031-1295441. PMID: 22706938
Real-time contrast-enhanced ultrasound of the spleen: examination technique and preliminary clinical experience.
Catalano O, Lobianco R, Sandomenico F, D'Elia G, Siani A
Radiol Med 2003 Oct;106(4):338-56. PMID: 14612826
Diagnosis of splenic involvement in Hodgkin's disease by radionuclide evaluation of splenic contraction in response to adrenaline.
Osadchaya TI, Vasilo NI, Baisogolov GD
J Nucl Med 1980 Apr;21(4):384-6. PMID: 7381566

Therapy

Breath-Hold Diving.
Fitz-Clarke JR
Compr Physiol 2018 Mar 25;8(2):585-630. doi: 10.1002/cphy.c160008. PMID: 29687909
Effect of hypercapnia on spleen-related haemoglobin increase during apnea.
Richardson MX, Engan HK, Lodin-Sundström A, Schagatay E
Diving Hyperb Med 2012 Mar;42(1):4-9. PMID: 22437969
Spleen and cardiovascular function during short apneas in divers.
Palada I, Eterovic D, Obad A, Bakovic D, Valic Z, Ivancev V, Lojpur M, Shoemaker JK, Dujic Z
J Appl Physiol (1985) 2007 Dec;103(6):1958-63. Epub 2007 Oct 18 doi: 10.1152/japplphysiol.00182.2007. PMID: 17947504
The human spleen as an erythrocyte reservoir in diving-related interventions.
Espersen K, Frandsen H, Lorentzen T, Kanstrup IL, Christensen NJ
J Appl Physiol (1985) 2002 May;92(5):2071-9. doi: 10.1152/japplphysiol.00055.2001. PMID: 11960959
Splenic contraction during breath-hold diving in the Korean ama.
Hurford WE, Hong SK, Park YS, Ahn DW, Shiraki K, Mohri M, Zapol WM
J Appl Physiol (1985) 1990 Sep;69(3):932-6. doi: 10.1152/jappl.1990.69.3.932. PMID: 2246181

Prognosis

Post-stroke infections associated with spleen volume reduction: A pilot study.
Nous A, Peeters I, Nieboer K, Vanbinst AM, De Keyser J, De Raedt S
PLoS One 2020;15(5):e0232497. Epub 2020 May 11 doi: 10.1371/journal.pone.0232497. PMID: 32392257Free PMC Article
Splenic contraction: a new member of the hypovolemic shock complex.
Enslow MS, Preece SR, Wildman-Tobriner B, Enslow RA, Mazurowski M, Nelson RC
Abdom Radiol (NY) 2018 Sep;43(9):2375-2383. doi: 10.1007/s00261-018-1478-3. PMID: 29460045
Acute splenic responses in patients with ischemic stroke and intracerebral hemorrhage.
Vahidy FS, Parsha KN, Rahbar MH, Lee M, Bui TT, Nguyen C, Barreto AD, Bambhroliya AB, Sahota P, Yang B, Aronowski J, Savitz SI
J Cereb Blood Flow Metab 2016 Jun;36(6):1012-21. Epub 2015 Oct 2 doi: 10.1177/0271678X15607880. PMID: 26661179Free PMC Article

Clinical prediction guides

Splenic contraction is enhanced by exercise at simulated high altitude.
Lodin-Sundström A, Holmström P, Ekstam M, Söderberg D, Schagatay E
Eur J Appl Physiol 2021 Jun;121(6):1725-1732. Epub 2021 Mar 8 doi: 10.1007/s00421-021-04637-0. PMID: 33683439Free PMC Article
Pulsed Ultrasound of the Spleen Prolongs Survival of Rats With Severe Intra-abdominal Sepsis.
Zhang A, Charles EJ, Xing J, Sawyer RG, Yang Z
J Surg Res 2021 Mar;259:97-105. Epub 2020 Dec 3 doi: 10.1016/j.jss.2020.11.005. PMID: 33279849Free PMC Article
Splenic contraction: a new member of the hypovolemic shock complex.
Enslow MS, Preece SR, Wildman-Tobriner B, Enslow RA, Mazurowski M, Nelson RC
Abdom Radiol (NY) 2018 Sep;43(9):2375-2383. doi: 10.1007/s00261-018-1478-3. PMID: 29460045
Association Between Splenic Contraction and the Systemic Inflammatory Response After Acute Ischemic Stroke Varies with Age and Race.
Zha A, Vahidy F, Randhawa J, Parsha K, Bui T, Aronowski J, Savitz SI
Transl Stroke Res 2018 Oct;9(5):484-492. Epub 2017 Dec 27 doi: 10.1007/s12975-017-0596-5. PMID: 29282627Free PMC Article
Total haemoglobin mass and spleen contraction: a study on competitive apnea divers, non-diving athletes and untrained control subjects.
Prommer N, Ehrmann U, Schmidt W, Steinacker JM, Radermacher P, Muth CM
Eur J Appl Physiol 2007 Dec;101(6):753-9. Epub 2007 Sep 14 doi: 10.1007/s00421-007-0556-y. PMID: 17874121

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