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Lacrimal Gland Myoepithelial Carcinoma

MedGen UID:
1779837
•Concept ID:
C5448120
•
Neoplastic Process

Definition

A carcinoma that arises from the lacrimal gland. It is characterized by the presence of a malignant cellular infiltrate exhibiting myoepithelial differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLacrimal Gland Myoepithelial Carcinoma

Recent clinical studies

Etiology

Clinical Implications of Goblet Cells in Dacryoadenosis and Normal Human Lacrimal Glands.
Jakobiec FA, Eagle RC Jr, Selig M, Ma L, Shields C
Am J Ophthalmol 2020 May;213:267-282. Epub 2020 Jan 30 doi: 10.1016/j.ajo.2020.01.029. PMID: 32006483
The role of biopsy in lacrimal gland inflammation: A clinicopathologic study.
Luemsamran P, Rootman J, White VA, Nassiri N, Heran MKS
Orbit 2017 Dec;36(6):411-418. Epub 2017 Aug 17 doi: 10.1080/01676830.2017.1352608. PMID: 28816552

Diagnosis

Epithelial lacrimal gland tumors in dogs and cats: Is the human WHO classification appropriate for animals?
Giudice C, Nordio L, Cadonici M, Perelli MN, Caniatti M
Vet Pathol 2021 Sep;58(5):935-944. Epub 2021 Jul 6 doi: 10.1177/03009858211025791. PMID: 34225508
Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland: Case Report of Youngest Patient.
Anjum S, Modaboyina S, Sen S, Sharma MC, Meel R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):e141-e144. doi: 10.1097/IOP.0000000000001663. PMID: 32332692
More than meets the eye.
White-Gibson A, Lennon P, O'Regan E, Timon C
BMJ Case Rep 2019 Feb 7;12(2) doi: 10.1136/bcr-2015-212000. PMID: 30737321Free PMC Article
Unusual pleomorphic adenoma of the lacrimal Gland: Immunohistochemical demonstration of PLAG1 and HMGA2 oncoproteins.
Jakobiec FA, Stagner AM, Eagle RC Jr, Lally SE, Krane JF
Surv Ophthalmol 2017 Mar-Apr;62(2):219-226. Epub 2016 Aug 25 doi: 10.1016/j.survophthal.2016.08.001. PMID: 27567603
The radiological spectrum of orbital pathologies that involve the lacrimal gland and the lacrimal fossa.
Jung WS, Ahn KJ, Park MR, Kim JY, Choi JJ, Kim BS, Hahn ST
Korean J Radiol 2007 Jul-Aug;8(4):336-42. doi: 10.3348/kjr.2007.8.4.336. PMID: 17673845Free PMC Article

Therapy

The role of biopsy in lacrimal gland inflammation: A clinicopathologic study.
Luemsamran P, Rootman J, White VA, Nassiri N, Heran MKS
Orbit 2017 Dec;36(6):411-418. Epub 2017 Aug 17 doi: 10.1080/01676830.2017.1352608. PMID: 28816552

Prognosis

Epithelial lacrimal gland tumors in dogs and cats: Is the human WHO classification appropriate for animals?
Giudice C, Nordio L, Cadonici M, Perelli MN, Caniatti M
Vet Pathol 2021 Sep;58(5):935-944. Epub 2021 Jul 6 doi: 10.1177/03009858211025791. PMID: 34225508
Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland.
Garakani R, Kersten R, Pekmezci M
Ophthalmic Plast Reconstr Surg 2020 Jan/Feb;36(1):e1-e3. doi: 10.1097/IOP.0000000000001491. PMID: 31743286
Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland 14 Years After En Bloc Resection of a Pleomorphic Lacrimal Gland Adenoma.
Gonçalves AC, de Lima PP, Monteiro ML
Ophthalmic Plast Reconstr Surg 2016 Mar-Apr;32(2):e42-4. doi: 10.1097/IOP.0000000000000225. PMID: 25025382
Adenoid cystic carcinoma of the lacrimal gland with wide and severe myoepithelial differentiation.
Mizokami H, Inokuchi A, Sawatsubashi M, Takagi S, Tsuda K, Tokunaga O
Auris Nasus Larynx 2002 Jan;29(1):77-82. doi: 10.1016/s0385-8146(01)00117-1. PMID: 11772496

Clinical prediction guides

Epithelial lacrimal gland tumors in dogs and cats: Is the human WHO classification appropriate for animals?
Giudice C, Nordio L, Cadonici M, Perelli MN, Caniatti M
Vet Pathol 2021 Sep;58(5):935-944. Epub 2021 Jul 6 doi: 10.1177/03009858211025791. PMID: 34225508
Clinical Implications of Goblet Cells in Dacryoadenosis and Normal Human Lacrimal Glands.
Jakobiec FA, Eagle RC Jr, Selig M, Ma L, Shields C
Am J Ophthalmol 2020 May;213:267-282. Epub 2020 Jan 30 doi: 10.1016/j.ajo.2020.01.029. PMID: 32006483
Unusual pleomorphic adenoma of the lacrimal Gland: Immunohistochemical demonstration of PLAG1 and HMGA2 oncoproteins.
Jakobiec FA, Stagner AM, Eagle RC Jr, Lally SE, Krane JF
Surv Ophthalmol 2017 Mar-Apr;62(2):219-226. Epub 2016 Aug 25 doi: 10.1016/j.survophthal.2016.08.001. PMID: 27567603
Adenoid cystic carcinoma of the lacrimal gland with wide and severe myoepithelial differentiation.
Mizokami H, Inokuchi A, Sawatsubashi M, Takagi S, Tsuda K, Tokunaga O
Auris Nasus Larynx 2002 Jan;29(1):77-82. doi: 10.1016/s0385-8146(01)00117-1. PMID: 11772496
Distribution of cytoskeletal and contractile proteins in normal and tumour bearing salivary and lacrimal glands.
Leoncini P, Cintorino M, Vindigni C, Leoncini L, Armellini D, Bugnoli M, Skalli O, Gabbiani G
Virchows Arch A Pathol Anat Histopathol 1988;412(4):329-37. doi: 10.1007/BF00750259. PMID: 2830713

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