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Elevated circulating acetone concentration

MedGen UID:
1780247
•Concept ID:
C5539422
•
Finding
HPO: HP:0032533

Definition

An increased level of acetone in the blood circulation. Acetone is one of the predominant ketone bodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating acetone concentration

Recent clinical studies

Etiology

Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
Kanikarla-Marie P, Jain SK
Free Radic Biol Med 2016 Jun;95:268-77. Epub 2016 Mar 29 doi: 10.1016/j.freeradbiomed.2016.03.020. PMID: 27036365Free PMC Article

Diagnosis

Mass-Spectrometry Analysis of Mixed-Breath, Isolated-Bronchial-Breath, and Gastric-Endoluminal-Air Volatile Fatty Acids in Esophagogastric Cancer.
Adam ME, Fehervari M, Boshier PR, Chin ST, Lin GP, Romano A, Kumar S, Hanna GB
Anal Chem 2019 Mar 5;91(5):3740-3746. Epub 2019 Feb 13 doi: 10.1021/acs.analchem.9b00148. PMID: 30699297

Therapy

Association of Circulating Ketone Bodies With Functional Outcomes After ST-Segment Elevation Myocardial Infarction.
de Koning MLY, Westenbrink BD, Assa S, Garcia E, Connelly MA, van Veldhuisen DJ, Dullaart RPF, Lipsic E, van der Harst P
J Am Coll Cardiol 2021 Oct 5;78(14):1421-1432. doi: 10.1016/j.jacc.2021.07.054. PMID: 34593124
On the mammalian acetone metabolism: from chemistry to clinical implications.
Kalapos MP
Biochim Biophys Acta 2003 May 2;1621(2):122-39. doi: 10.1016/s0304-4165(03)00051-5. PMID: 12726989
Endogenous ethanol production and hepatic disease following jejunoileal bypass for morbid obesity.
Mezey E, Imbembo AL, Potter JJ, Rent KC, Lombardo R, Holt PR
Am J Clin Nutr 1975 Nov;28(11):1277-83. doi: 10.1093/ajcn/28.11.1277. PMID: 1190105

Clinical prediction guides

Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study.
Pabst F, Miekisch W, Fuchs P, Kischkel S, Schubert JK
J Cardiothorac Surg 2007 Sep 18;2:37. doi: 10.1186/1749-8090-2-37. PMID: 17877828Free PMC Article
On the mammalian acetone metabolism: from chemistry to clinical implications.
Kalapos MP
Biochim Biophys Acta 2003 May 2;1621(2):122-39. doi: 10.1016/s0304-4165(03)00051-5. PMID: 12726989

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