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Diaschisis

MedGen UID:
1780734
•Concept ID:
C5544502
•
Disease or Syndrome

Definition

Loss or decreased brain function within intact region of the brain distant from the site of the lesion. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiaschisis

Professional guidelines

PubMed

Post-stroke Movement Disorders: Clinical Spectrum, Pathogenesis, and Management.
Tater P, Pandey S
Neurol India 2021 Mar-Apr;69(2):272-283. doi: 10.4103/0028-3886.314574. PMID: 33904435
Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.
Tay J, Morris RG, Markus HS
Int J Stroke 2021 Jul;16(5):510-518. Epub 2021 Feb 4 doi: 10.1177/1747493021990906. PMID: 33527880Free PMC Article

Recent clinical studies

Etiology

Ataxic hemiparesis: a narrative review for clinical practice in rehabilitation.
Sung MF, Lim JH
Top Stroke Rehabil 2024 Jul;31(5):537-545. Epub 2023 Nov 15 doi: 10.1080/10749357.2023.2281722. PMID: 37965878
Cerebellar injury in preterm infants.
Tam EWY
Handb Clin Neurol 2018;155:49-59. doi: 10.1016/B978-0-444-64189-2.00003-2. PMID: 29891076
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
The neurophysiology of concussion.
Hovda DA
Prog Neurol Surg 2014;28:28-37. Epub 2014 Jun 6 doi: 10.1159/000358749. PMID: 24923390
Potential mechanisms of cerebellar hypoplasia in prematurity.
Tam EW
Neuroradiology 2013 Sep;55 Suppl 2:41-6. Epub 2013 Jul 11 doi: 10.1007/s00234-013-1230-1. PMID: 23842990

Diagnosis

Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.
Tay J, Morris RG, Markus HS
Int J Stroke 2021 Jul;16(5):510-518. Epub 2021 Feb 4 doi: 10.1177/1747493021990906. PMID: 33527880Free PMC Article
The connectomics of brain disorders.
Fornito A, Zalesky A, Breakspear M
Nat Rev Neurosci 2015 Mar;16(3):159-72. doi: 10.1038/nrn3901. PMID: 25697159
Diaschisis: past, present, future.
Carrera E, Tononi G
Brain 2014 Sep;137(Pt 9):2408-22. Epub 2014 May 28 doi: 10.1093/brain/awu101. PMID: 24871646
Cerebellar mutism.
Küper M, Timmann D
Brain Lang 2013 Dec;127(3):327-33. Epub 2013 Feb 9 doi: 10.1016/j.bandl.2013.01.001. PMID: 23398780
Subcortical aphasia.
Nadeau SE, Crosson B
Brain Lang 1997 Jul;58(3):355-402; discussion 418-23. doi: 10.1006/brln.1997.1707. PMID: 9222518

Therapy

Simulated Attack Reveals How Lesions Affect Network Properties in Poststroke Aphasia.
Medaglia JD, Erickson BA, Pustina D, Kelkar AS, DeMarco AT, Dickens JV, Turkeltaub PE
J Neurosci 2022 Jun 15;42(24):4913-4926. Epub 2022 May 11 doi: 10.1523/JNEUROSCI.1163-21.2022. PMID: 35545436Free PMC Article
Cerebellar Mutism Syndrome: An Overview of the Pathophysiology in Relation to the Cerebrocerebellar Anatomy, Risk Factors, Potential Treatments, and Outcomes.
Ashida R, Nazar N, Edwards R, Teo M
World Neurosurg 2021 Sep;153:63-74. Epub 2021 Jun 19 doi: 10.1016/j.wneu.2021.06.065. PMID: 34157457
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
Silencing the brain may be better than stimulating it. The GABA effect.
Pistoia F, Sarà M, Sacco S, Franceschini M, Carolei A
Curr Pharm Des 2014;20(26):4154-66. PMID: 24025066
Drugs for stroke recovery: the example of amphetamines.
Martinsson L, Eksborg S
Drugs Aging 2004;21(2):67-79. doi: 10.2165/00002512-200421020-00001. PMID: 14960125

Prognosis

Ataxic hemiparesis: a narrative review for clinical practice in rehabilitation.
Sung MF, Lim JH
Top Stroke Rehabil 2024 Jul;31(5):537-545. Epub 2023 Nov 15 doi: 10.1080/10749357.2023.2281722. PMID: 37965878
Post-stroke Movement Disorders: Clinical Spectrum, Pathogenesis, and Management.
Tater P, Pandey S
Neurol India 2021 Mar-Apr;69(2):272-283. doi: 10.4103/0028-3886.314574. PMID: 33904435
Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.
Tay J, Morris RG, Markus HS
Int J Stroke 2021 Jul;16(5):510-518. Epub 2021 Feb 4 doi: 10.1177/1747493021990906. PMID: 33527880Free PMC Article
The connectomics of brain disorders.
Fornito A, Zalesky A, Breakspear M
Nat Rev Neurosci 2015 Mar;16(3):159-72. doi: 10.1038/nrn3901. PMID: 25697159
Potential mechanisms of cerebellar hypoplasia in prematurity.
Tam EW
Neuroradiology 2013 Sep;55 Suppl 2:41-6. Epub 2013 Jul 11 doi: 10.1007/s00234-013-1230-1. PMID: 23842990

Clinical prediction guides

Resolution of diaschisis contributes to early recovery from post-stroke aphasia.
Wawrzyniak M, Schneider HR, Klingbeil J, Stockert A, Hartwigsen G, Weiller C, Saur D
Neuroimage 2022 May 1;251:119001. Epub 2022 Feb 13 doi: 10.1016/j.neuroimage.2022.119001. PMID: 35172200
Nuclear medicine of the cerebellum.
Vella A, Mascalchi M
Handb Clin Neurol 2018;154:251-266. doi: 10.1016/B978-0-444-63956-1.00015-1. PMID: 29903443
The connectomics of brain disorders.
Fornito A, Zalesky A, Breakspear M
Nat Rev Neurosci 2015 Mar;16(3):159-72. doi: 10.1038/nrn3901. PMID: 25697159
Radionuclide imaging in ischemic stroke.
Heiss WD
J Nucl Med 2014 Nov;55(11):1831-41. Epub 2014 Oct 9 doi: 10.2967/jnumed.114.145003. PMID: 25300599
The neurophysiology of concussion.
Hovda DA
Prog Neurol Surg 2014;28:28-37. Epub 2014 Jun 6 doi: 10.1159/000358749. PMID: 24923390

Recent systematic reviews

Syndrome of the third frontal convolution: Léon Ectors´ legacy on paradoxical ipsilateral hemiparesis.
Carrasco-Moro R, Martínez-San Millán JS, Pérez-Pérez M, Pascual JM
Acta Neurol Belg 2024 Feb;124(1):37-48. Epub 2023 Oct 10 doi: 10.1007/s13760-023-02394-9. PMID: 37815739
Systematic Review and Meta-Analyses of Word Production Abilities in Dysfunction of the Basal Ganglia: Stroke, Small Vessel Disease, Parkinson's Disease, and Huntington's Disease.
Camerino I, Ferreira J, Vonk JM, Kessels RPC, de Leeuw FE, Roelofs A, Copland D, Piai V
Neuropsychol Rev 2024 Mar;34(1):1-26. Epub 2022 Dec 24 doi: 10.1007/s11065-022-09570-3. PMID: 36564612
Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery-a systematic review.
Ahmadian N, van Baarsen KM, Robe PAJT, Hoving EW
Childs Nerv Syst 2021 Sep;37(9):2743-2751. Epub 2021 Jun 21 doi: 10.1007/s00381-021-05225-5. PMID: 34155533Free PMC Article
Relationship between resting-state fMRI functional connectivity with motor and language outcome after perinatal brain injury - A systematic review.
Ní Bhroin M, Molloy EJ, Bokde ALW
Eur J Paediatr Neurol 2021 Jul;33:36-49. Epub 2021 May 15 doi: 10.1016/j.ejpn.2021.05.007. PMID: 34058624
Drugs for stroke recovery: the example of amphetamines.
Martinsson L, Eksborg S
Drugs Aging 2004;21(2):67-79. doi: 10.2165/00002512-200421020-00001. PMID: 14960125

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