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Primary obstructive megaureter

MedGen UID:
1781352
•Concept ID:
C5539884
•
Anatomical Abnormality
HPO: HP:4000035

Definition

Megaurater associated with obstruction or an adynamic ureteral segment in the ureterovesical junction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary obstructive megaureter

Professional guidelines

PubMed

British Association of Paediatric Urologists consensus statement on the management of the primary obstructive megaureter.
Farrugia MK, Hitchcock R, Radford A, Burki T, Robb A, Murphy F; British Association of Paediatric Urologists
J Pediatr Urol 2014 Feb;10(1):26-33. Epub 2013 Oct 16 doi: 10.1016/j.jpurol.2013.09.018. PMID: 24206785
Primary obstructive megaureter in adults: need for an aggressive management strategy.
Dorairajan LN, Hemal AK, Gupta NP, Wadhwa SN
Int Urol Nephrol 1999;31(5):633-41. doi: 10.1023/a:1007104404287. PMID: 10755353
Clinical outcome and management of prenatally diagnosed primary megaureters.
Liu HY, Dhillon HK, Yeung CK, Diamond DA, Duffy PG, Ransley PG
J Urol 1994 Aug;152(2 Pt 2):614-7. doi: 10.1016/s0022-5347(17)32664-2. PMID: 8021982

Recent clinical studies

Etiology

Endoscopic balloon dilation of primary obstructive megaureter: is fluoroscopic guidance necessary?
Ortiz R, Burgos L, Fernández-Bautista B, Parente A, Ordóñez J, Angulo JM
World J Urol 2023 Oct;41(10):2861-2867. Epub 2023 Sep 10 doi: 10.1007/s00345-023-04572-z. PMID: 37690062
Ureteral reimplantation for pediatric vesicoureteral reflux and primary obstructive megaureter: Transvesicoscopic cohen vs. Politano-Leadbetter approaches.
Lin S, Xu D, He S, Li L, Xu H, Tang K
J Pediatr Urol 2022 Aug;18(4):516.e1-516.e9. Epub 2022 Mar 15 doi: 10.1016/j.jpurol.2022.03.009. PMID: 35659823
Ureteral Reimplantation for Primary Obstructive Megaureter in Pediatric Patients: Is It Time for Robot-Assisted Approach?
Sforza S, Cini C, Negri E, Bortot G, Di Maida F, Cito G, Escolino M, Esposito C, Minervini A, Masieri L
J Laparoendosc Adv Surg Tech A 2022 Feb;32(2):231-236. Epub 2021 Dec 14 doi: 10.1089/lap.2021.0246. PMID: 34905408
Endoscopic management of primary obstructive megaureter in pediatrics.
Teklali Y, Robert Y, Boillot B, Overs C, Piolat C, Rabattu PY
J Pediatr Urol 2018 Oct;14(5):382-387. Epub 2018 Jun 28 doi: 10.1016/j.jpurol.2018.05.027. PMID: 30006257
Endoscopic Management of Primary Obstructive Megaureter: A Systematic Review.
Doudt AD, Pusateri CR, Christman MS
J Endourol 2018 Jun;32(6):482-487. doi: 10.1089/end.2017.0434. PMID: 29676162

Diagnosis

Laparoscopic Extravesical Reimplantation in Children with Primary Obstructive Megaureter.
Lopez M, Perez-Etchepare E, Bustangi N, Godik O, Juricic M, Varlet F, Gutierrez R, Gomez Culebras M, Gander R, Royo G, Asensio M
J Laparoendosc Adv Surg Tech A 2023 Jul;33(7):713-718. Epub 2020 Mar 26 doi: 10.1089/lap.2019.0396. PMID: 32212997
Ureteral reimplantation for pediatric vesicoureteral reflux and primary obstructive megaureter: Transvesicoscopic cohen vs. Politano-Leadbetter approaches.
Lin S, Xu D, He S, Li L, Xu H, Tang K
J Pediatr Urol 2022 Aug;18(4):516.e1-516.e9. Epub 2022 Mar 15 doi: 10.1016/j.jpurol.2022.03.009. PMID: 35659823
Ureteral Reimplantation for Primary Obstructive Megaureter in Pediatric Patients: Is It Time for Robot-Assisted Approach?
Sforza S, Cini C, Negri E, Bortot G, Di Maida F, Cito G, Escolino M, Esposito C, Minervini A, Masieri L
J Laparoendosc Adv Surg Tech A 2022 Feb;32(2):231-236. Epub 2021 Dec 14 doi: 10.1089/lap.2021.0246. PMID: 34905408
Megaureter.
Manzoni C
Rays 2002 Apr-Jun;27(2):83-5. PMID: 12696257
Primary obstructive megaureter.
Sripathi V, King PA, Thomson MR, Bogle MS
J Pediatr Surg 1991 Jul;26(7):826-9. doi: 10.1016/0022-3468(91)90148-m. PMID: 1895193

Therapy

Endoscopic dilatation/incision of primary obstructive megaureter. A systematic review. On behalf of the EAU paediatric urology guidelines panel.
Skott M, Gnech M, Hoen LA', Kennedy U, Van Uitert A, Zachou A, Yuan Y, Quaedackers J, Silay MS, Rawashdeh YF, Burgu B, Castagnetti M, O'Kelly F, Bogaert G, Radmayr C
J Pediatr Urol 2024 Feb;20(1):47-56. Epub 2023 Sep 13 doi: 10.1016/j.jpurol.2023.09.005. PMID: 37758534
Endoscopic balloon dilation of primary obstructive megaureter: is fluoroscopic guidance necessary?
Ortiz R, Burgos L, Fernández-Bautista B, Parente A, Ordóñez J, Angulo JM
World J Urol 2023 Oct;41(10):2861-2867. Epub 2023 Sep 10 doi: 10.1007/s00345-023-04572-z. PMID: 37690062
Laparoscopic Extravesical Reimplantation in Children with Primary Obstructive Megaureter.
Lopez M, Perez-Etchepare E, Bustangi N, Godik O, Juricic M, Varlet F, Gutierrez R, Gomez Culebras M, Gander R, Royo G, Asensio M
J Laparoendosc Adv Surg Tech A 2023 Jul;33(7):713-718. Epub 2020 Mar 26 doi: 10.1089/lap.2019.0396. PMID: 32212997
Postoperative JJ stent is not necessary after balloon high-pressure endoscopic dilatation of primary obstructive megaureter.
Faraj S, Loubersac T, Graveleau A, Alliot H, Camby C, Leclair MD
J Pediatr Urol 2022 Jun;18(3):369.e1-369.e7. Epub 2022 Apr 13 doi: 10.1016/j.jpurol.2022.03.028. PMID: 35562267
Endoscopic management of primary obstructive megaureter in pediatrics.
Teklali Y, Robert Y, Boillot B, Overs C, Piolat C, Rabattu PY
J Pediatr Urol 2018 Oct;14(5):382-387. Epub 2018 Jun 28 doi: 10.1016/j.jpurol.2018.05.027. PMID: 30006257

Prognosis

Spontaneous resolution and the role of endoscopic surgery in the treatment of primary obstructive megaureter: a review of the literature.
Isac GV, Danila GM, Ionescu SN
Pediatr Med Chir 2023 Dec 19;45(2) doi: 10.4081/pmc.2023.327. PMID: 38112615
Antegrade endoscopic dilatation as an alternative approach to primary obstructive megaureter.
Álvarez N, García-Núñez B, Esteva C, Pérez-Gaspar M, Santiago S, Betancourth J, Jiménez J, Falcó J
Cir Pediatr 2021 Apr 1;34(2):100-104. PMID: 33826264
Endoscopic balloon dilatation of primary obstructive megaureter: method standardization and predictive prognostic factors.
Chiarenza SF, Bleve C, Zolpi E, Battaglino F, Fasoli L, Bucci V
Pediatr Med Chir 2019 Dec 23;41(2) doi: 10.4081/pmc.2019.219. PMID: 31867939
Long-term outcome of JJ stent insertion for primary obstructive megaureter in children.
Awad K, Woodward MN, Shalaby MS
J Pediatr Urol 2019 Feb;15(1):66.e1-66.e5. Epub 2018 Oct 5 doi: 10.1016/j.jpurol.2018.09.011. PMID: 30385050
Endoscopic balloon dilatation in primary obstructive megaureter: Long-term results.
Casal Beloy I, Somoza Argibay I, García González M, García Novoa MA, Míguez Fortes LM, Dargallo Carbonell T
J Pediatr Urol 2018 Apr;14(2):167.e1-167.e5. Epub 2017 Nov 21 doi: 10.1016/j.jpurol.2017.10.016. PMID: 29398584

Clinical prediction guides

Ureteral reimplantation for pediatric vesicoureteral reflux and primary obstructive megaureter: Transvesicoscopic cohen vs. Politano-Leadbetter approaches.
Lin S, Xu D, He S, Li L, Xu H, Tang K
J Pediatr Urol 2022 Aug;18(4):516.e1-516.e9. Epub 2022 Mar 15 doi: 10.1016/j.jpurol.2022.03.009. PMID: 35659823
Ureteral Reimplantation for Primary Obstructive Megaureter in Pediatric Patients: Is It Time for Robot-Assisted Approach?
Sforza S, Cini C, Negri E, Bortot G, Di Maida F, Cito G, Escolino M, Esposito C, Minervini A, Masieri L
J Laparoendosc Adv Surg Tech A 2022 Feb;32(2):231-236. Epub 2021 Dec 14 doi: 10.1089/lap.2021.0246. PMID: 34905408
Endoscopic balloon dilatation of primary obstructive megaureter: method standardization and predictive prognostic factors.
Chiarenza SF, Bleve C, Zolpi E, Battaglino F, Fasoli L, Bucci V
Pediatr Med Chir 2019 Dec 23;41(2) doi: 10.4081/pmc.2019.219. PMID: 31867939
Endoscopic balloon dilatation in primary obstructive megaureter: Long-term results.
Casal Beloy I, Somoza Argibay I, García González M, García Novoa MA, Míguez Fortes LM, Dargallo Carbonell T
J Pediatr Urol 2018 Apr;14(2):167.e1-167.e5. Epub 2017 Nov 21 doi: 10.1016/j.jpurol.2017.10.016. PMID: 29398584
Primary obstructive megaureter: cutting balloon endo-ureterotomy.
Smeulders N, Yankovic F, Chippington S, Cherian A
J Pediatr Urol 2013 Oct;9(5):692.e1-2. Epub 2013 Jun 5 doi: 10.1016/j.jpurol.2013.04.010. PMID: 23759477

Recent systematic reviews

Endoscopic dilatation/incision of primary obstructive megaureter. A systematic review. On behalf of the EAU paediatric urology guidelines panel.
Skott M, Gnech M, Hoen LA', Kennedy U, Van Uitert A, Zachou A, Yuan Y, Quaedackers J, Silay MS, Rawashdeh YF, Burgu B, Castagnetti M, O'Kelly F, Bogaert G, Radmayr C
J Pediatr Urol 2024 Feb;20(1):47-56. Epub 2023 Sep 13 doi: 10.1016/j.jpurol.2023.09.005. PMID: 37758534
High-pressure balloon dilatation of primary obstructive megaureter in children: a systematic review.
Ripatti L, Viljamaa HR, Suihko A, Pakkasjärvi N
BMC Urol 2023 Mar 3;23(1):30. doi: 10.1186/s12894-023-01199-5. PMID: 36869342Free PMC Article
Endoscopic Management of Primary Obstructive Megaureter: A Systematic Review.
Doudt AD, Pusateri CR, Christman MS
J Endourol 2018 Jun;32(6):482-487. doi: 10.1089/end.2017.0434. PMID: 29676162

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