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Formation of multiple pronuclei during fertilization

MedGen UID:
1781576
•Concept ID:
C5539859
•
Cell or Molecular Dysfunction
HPO: HP:4000008

Definition

Pronuclei formation is a critical process during fertilization. Normally, there are two pronuclei (2PN), including the paternal pronucleus and the maternal pronucleus, in the zygote after fertilization. It is generally accepted that multiple pronuclei (MPN) formation is due to the abnormal extrusion of the second polar body or to abnormal fertilization with multiple sperm. The MPN therefore can cause infertility and recurrent failure of IVF/ICSI. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFormation of multiple pronuclei during fertilization

Conditions with this feature

Oocyte maturation defect 10
MedGen UID:
1766720
•Concept ID:
C5436938
•
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-10 (OZEMA10) is characterized by high rates of abnormal fertilization of mature oocytes, with development of multiple pronuclei or absent pronucleus. Morphologically normal zygotes often undergo early embryonic arrest, and surviving embryos fail to establish a successful pregnancy after implantation (Wang et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.
See: Condition Record
Oocyte maturation defect 10

Recent clinical studies

Etiology

Are Early Embryo Cleavage Kinetics Affected by Energy Substrates in Different Culture Media?
Ma BX, Huang B, Chen D, Jin L, Rao Q
Curr Med Sci 2022 Dec;42(6):1297-1304. Epub 2022 Dec 22 doi: 10.1007/s11596-022-2648-7. PMID: 36544035
Timing considerations for removal of early cumulus cells in short-term insemination strategies.
Liu Z, Liu Q, Jiang M, Chen X, Lin C, Guo Y
Reprod Fertil Dev 2021 Dec;33(18):881-885. doi: 10.1071/RD21259. PMID: 34852900
Discrepancy between sperm acrosin activity and sperm morphology: significance for fertilization in vitro.
Langlois MR, Oorlynck L, Vandekerckhove F, Criel A, Bernard D, Blaton V
Clin Chim Acta 2005 Jan;351(1-2):121-9. doi: 10.1016/j.cccn.2004.08.001. PMID: 15563880

Diagnosis

Discrepancy between sperm acrosin activity and sperm morphology: significance for fertilization in vitro.
Langlois MR, Oorlynck L, Vandekerckhove F, Criel A, Bernard D, Blaton V
Clin Chim Acta 2005 Jan;351(1-2):121-9. doi: 10.1016/j.cccn.2004.08.001. PMID: 15563880

Prognosis

Discrepancy between sperm acrosin activity and sperm morphology: significance for fertilization in vitro.
Langlois MR, Oorlynck L, Vandekerckhove F, Criel A, Bernard D, Blaton V
Clin Chim Acta 2005 Jan;351(1-2):121-9. doi: 10.1016/j.cccn.2004.08.001. PMID: 15563880
Selection based on morphological assessment of oocytes and embryos at different stages of preimplantation development: a review.
Ebner T, Moser M, Sommergruber M, Tews G
Hum Reprod Update 2003 May-Jun;9(3):251-62. doi: 10.1093/humupd/dmg021. PMID: 12859046
Male and female genomes associated in a single pronucleus in human zygotes.
Levron J, Munné S, Willadsen S, Rosenwaks Z, Cohen J
Biol Reprod 1995 Mar;52(3):653-7. doi: 10.1095/biolreprod52.3.653. PMID: 7756458

Clinical prediction guides

Are Early Embryo Cleavage Kinetics Affected by Energy Substrates in Different Culture Media?
Ma BX, Huang B, Chen D, Jin L, Rao Q
Curr Med Sci 2022 Dec;42(6):1297-1304. Epub 2022 Dec 22 doi: 10.1007/s11596-022-2648-7. PMID: 36544035
Time-lapse observation and transcriptome analysis of a case with repeated multiple pronuclei after IVF/ICSI.
Dai J, Leng LZ, Lu CF, Gong F, Zhang SP, Zheng W, Lu GX, Lin G
J Assist Reprod Genet 2017 Sep;34(9):1189-1197. Epub 2017 Jun 22 doi: 10.1007/s10815-017-0972-9. PMID: 28643089Free PMC Article
Discrepancy between sperm acrosin activity and sperm morphology: significance for fertilization in vitro.
Langlois MR, Oorlynck L, Vandekerckhove F, Criel A, Bernard D, Blaton V
Clin Chim Acta 2005 Jan;351(1-2):121-9. doi: 10.1016/j.cccn.2004.08.001. PMID: 15563880

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