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Lacrimal Gland Oncocytic Adenocarcinoma

MedGen UID:
1782239
•Concept ID:
C5446388
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLacrimal Gland Oncocytic Adenocarcinoma

Professional guidelines

PubMed

Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539
Mutational landscape of lacrimal gland carcinomas and implications for treatment.
Bell D, Sniegowski MC, Wani K, Prieto V, Esmaeli B
Head Neck 2016 Apr;38 Suppl 1(Suppl 1):E724-E729. Epub 2015 Jun 15 doi: 10.1002/hed.24078. PMID: 25899808Free PMC Article

Recent clinical studies

Etiology

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.
Liu R, Ren T, Li J, Wang N, Xu L, Guo Q, Zhang H, Ma J
J Cancer Res Clin Oncol 2024 Jan 23;150(1):26. doi: 10.1007/s00432-023-05510-7. PMID: 38263473Free PMC Article
Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors.
Aryasit O, Amornthatree P, Tsutsumi WD, Sittivarakul W, Geater AF, Tengtrisorn S, Prapakornkovit V
Sci Rep 2023 Oct 3;13(1):16615. doi: 10.1038/s41598-023-43817-0. PMID: 37789105Free PMC Article
Lacrimal Sac Tumors: A Single-institution Experience, Including New Insights.
Wakasaki T, Yasumatsu R, Tanabe M, Yoshikawa H, Jiromaru R, Hashimoto K, Matsuo M, Fujimura A, Nakagawa T
In Vivo 2023 May-Jun;37(3):1219-1225. doi: 10.21873/invivo.13198. PMID: 37103086Free PMC Article
Basaloid adenocarcinoma of the lacrimal sac: A rare entity and approach to management.
Huggins AB, Stefanyszyn MA, Nyquist G, Rabinowitz MP
Orbit 2017 Dec;36(6):441-444. Epub 2017 Aug 24 doi: 10.1080/01676830.2017.1337186. PMID: 28837389
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588

Diagnosis

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.
Liu R, Ren T, Li J, Wang N, Xu L, Guo Q, Zhang H, Ma J
J Cancer Res Clin Oncol 2024 Jan 23;150(1):26. doi: 10.1007/s00432-023-05510-7. PMID: 38263473Free PMC Article
Lacrimal Sac Tumors: A Single-institution Experience, Including New Insights.
Wakasaki T, Yasumatsu R, Tanabe M, Yoshikawa H, Jiromaru R, Hashimoto K, Matsuo M, Fujimura A, Nakagawa T
In Vivo 2023 May-Jun;37(3):1219-1225. doi: 10.21873/invivo.13198. PMID: 37103086Free PMC Article
Primary ductal adenocarcinoma of the lacrimal gland: A review and report of five cases.
See TRO, Stålhammar G, Tang T, Manusow JS, Jordan DR, Nerad JA, Kersten RC, Yonkers M, Syed NA, Brownstein S, Grossniklaus HE
Surv Ophthalmol 2020 May-Jun;65(3):371-380. Epub 2019 Dec 16 doi: 10.1016/j.survophthal.2019.11.002. PMID: 31837385Free PMC Article
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539
Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey.
von Holstein SL, Coupland SE, Briscoe D, Le Tourneau C, Heegaard S
Acta Ophthalmol 2013 May;91(3):195-206. Epub 2012 Apr 4 doi: 10.1111/j.1755-3768.2012.02402.x. PMID: 22471335

Therapy

Metastatic HER2 lacrimal/salivary gland duct adenocarcinoma.
Mansi RA, Morris B, Fulcher T, McDermott JH
BMJ Case Rep 2023 Jun 30;16(6) doi: 10.1136/bcr-2022-253928. PMID: 37399351Free PMC Article
Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma: A Long-Term Follow-up Study of a Trimodal Strategy.
Tse DT, Benedetto PW, Tse BC, Feuer WJ
Am J Ophthalmol 2022 Aug;240:239-251. Epub 2022 Apr 2 doi: 10.1016/j.ajo.2022.03.027. PMID: 35381201Free PMC Article
Multimodal therapy in the management of lacrimal gland adenoid cystic carcinoma.
Yang J, Zhou C, Wang Y, Fan X, Jia R
BMC Ophthalmol 2019 Jun 8;19(1):125. doi: 10.1186/s12886-019-1110-5. PMID: 31176360Free PMC Article
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma.
Zhang M, Fathy C, Breazzano MP, Hollar M, Barahimi B
Int Ophthalmol Clin 2017 Winter;57(1):143-152. doi: 10.1097/IIO.0000000000000158. PMID: 27898620
Salivary gland tumors in children: a retrospective clinical review.
Varan A, Akyüz C, Ataş E, Yücel T, Aydın B, Yalçın B, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2014 Nov;31(8):681-6. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.942936. PMID: 25247345

Prognosis

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.
Liu R, Ren T, Li J, Wang N, Xu L, Guo Q, Zhang H, Ma J
J Cancer Res Clin Oncol 2024 Jan 23;150(1):26. doi: 10.1007/s00432-023-05510-7. PMID: 38263473Free PMC Article
Primary Malignant Epithelial Tumors of the Lacrimal Drainage System: A Major Review.
Singh S, Ali MJ
Orbit 2021 Jun;40(3):179-192. Epub 2020 Jun 8 doi: 10.1080/01676830.2020.1769684. PMID: 32506982
Primary ductal adenocarcinoma of the lacrimal gland: A review and report of five cases.
See TRO, Stålhammar G, Tang T, Manusow JS, Jordan DR, Nerad JA, Kersten RC, Yonkers M, Syed NA, Brownstein S, Grossniklaus HE
Surv Ophthalmol 2020 May-Jun;65(3):371-380. Epub 2019 Dec 16 doi: 10.1016/j.survophthal.2019.11.002. PMID: 31837385Free PMC Article
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539
Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey.
von Holstein SL, Coupland SE, Briscoe D, Le Tourneau C, Heegaard S
Acta Ophthalmol 2013 May;91(3):195-206. Epub 2012 Apr 4 doi: 10.1111/j.1755-3768.2012.02402.x. PMID: 22471335

Clinical prediction guides

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.
Liu R, Ren T, Li J, Wang N, Xu L, Guo Q, Zhang H, Ma J
J Cancer Res Clin Oncol 2024 Jan 23;150(1):26. doi: 10.1007/s00432-023-05510-7. PMID: 38263473Free PMC Article
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
Primary Mucoepidermoid Carcinoma of the Lacrimal Apparatus.
Sun H, Cai R, Zhai C, Song W, Sun J, Bi Y
Am J Ophthalmol 2022 Jul;239:170-179. Epub 2022 Mar 12 doi: 10.1016/j.ajo.2022.03.008. PMID: 35288069
Clinicopathological and immunohistochemical behavior of ductal carcinoma of the salivary and lacrimal gland in a Mexican Mestizo population.
Luna-Ortiz K, Dominguez-Malagon H, Corredor-Alonso GE, Reynoso-Noveron N, Herrera-Ponzanelli C, Luna-Peteuil Z, Zacarias-Ramon LC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):327-333. Epub 2021 Mar 24 doi: 10.1007/s00405-021-06757-x. PMID: 33763743
Prognostic impact of Notch1 receptor and clinicopathological High-Risk Predictors in lacrimal gland adenoid cystic carcinoma.
Anjum S, Sen S, Pushker N, Bajaj MS, Kashyap S, Bakhshi S, Chosdol K, Meel R, Sharma MC
Acta Ophthalmol 2021 Dec;99(8):e1467-e1473. Epub 2021 Mar 6 doi: 10.1111/aos.14812. PMID: 33675181

Recent systematic reviews

Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865

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