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Supratentorial primitive neuroectodermal tumor (SPNET)

MedGen UID:
1783047
•Concept ID:
C5542991
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSupratentorial primitive neuroectodermal tumor (SPNET)

Professional guidelines

PubMed

Treatment outcomes and late toxicities in patients with embryonal central nervous system tumors.
Odagiri K, Omura M, Hata M, Aida N, Niwa T, Goto H, Ito S, Adachi M, Yoshida H, Yuki H, Inoue T
Radiat Oncol 2014 Sep 11;9:201. doi: 10.1186/1748-717X-9-201. PMID: 25209395Free PMC Article

Recent clinical studies

Etiology

Adult primitive neuroectodermal tumors: the prognostic value of supratentorial location.
Gandhi R, Babu R, Cummings TJ, Adamson C
J Neurooncol 2013 Aug;114(1):141-8. Epub 2013 May 30 doi: 10.1007/s11060-013-1163-x. PMID: 23720066
Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor.
Li M, Lockwood W, Zielenska M, Northcott P, Ra YS, Bouffet E, Yoshimoto M, Rutka JT, Yan H, Taylor MD, Eberhart C, Hawkins CE, Lam W, Squire JA, Huang A
Cancer Genet 2012 May;205(5):220-31. doi: 10.1016/j.cancergen.2012.03.002. PMID: 22682621
Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?
Biswas S, Burke A, Cherian S, Williams D, Nicholson J, Horan G, Jefferies S, Williams M, Earl HM, Burnet NG, Hatcher H
Pediatr Blood Cancer 2009 Jul;52(7):796-803. doi: 10.1002/pbc.21899. PMID: 19202566
Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report.
Johnston DL, Keene DL, Lafay-Cousin L, Steinbok P, Sung L, Carret AS, Crooks B, Strother D, Wilson B, Odame I, Eisenstat DD, Mpofu C, Zelcer S, Huang A, Bouffet E
J Neurooncol 2008 Jan;86(1):101-8. Epub 2007 Jul 10 doi: 10.1007/s11060-007-9440-1. PMID: 17619825
Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous system.
Inda MM, Perot C, Guillaud-Bataille M, Danglot G, Rey JA, Bello MJ, Fan X, Eberhart C, Zazpe I, Portillo E, Tuñón T, Martínez-Peñuela JM, Bernheim A, Castresana JS
Histopathology 2005 Dec;47(6):631-7. doi: 10.1111/j.1365-2559.2005.02304.x. PMID: 16324202

Diagnosis

Embryonal tumors with multi-layered rosettes: a disease of dysregulated miRNAs.
Raghuram N, Khan S, Mumal I, Bouffet E, Huang A
J Neurooncol 2020 Oct;150(1):63-73. Epub 2020 Oct 22 doi: 10.1007/s11060-020-03633-2. PMID: 33090313
Pediatric glioblastoma with giant cells and "supratentorial" primitive neuroectodermal component - case report and review of the literature.
Georgiu C, MihuŢ E, Raus I, Mirescu ŞC, Szabo L, Şovrea AS
Rom J Morphol Embryol 2015;56(3):1165-71. PMID: 26662154
Adult primitive neuroectodermal tumors: the prognostic value of supratentorial location.
Gandhi R, Babu R, Cummings TJ, Adamson C
J Neurooncol 2013 Aug;114(1):141-8. Epub 2013 May 30 doi: 10.1007/s11060-013-1163-x. PMID: 23720066
A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature.
Ohba S, Yoshida K, Hirose Y, Ikeda E, Kawase T
J Neurooncol 2008 Jan;86(2):217-24. Epub 2007 Aug 23 doi: 10.1007/s11060-007-9466-4. PMID: 17713720
Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report.
Johnston DL, Keene DL, Lafay-Cousin L, Steinbok P, Sung L, Carret AS, Crooks B, Strother D, Wilson B, Odame I, Eisenstat DD, Mpofu C, Zelcer S, Huang A, Bouffet E
J Neurooncol 2008 Jan;86(1):101-8. Epub 2007 Jul 10 doi: 10.1007/s11060-007-9440-1. PMID: 17619825

Therapy

Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: a report from the Children's Oncology Group.
Jakacki RI, Burger PC, Kocak M, Boyett JM, Goldwein J, Mehta M, Packer RJ, Tarbell NJ, Pollack IF
Pediatr Blood Cancer 2015 May;62(5):776-83. Epub 2015 Feb 19 doi: 10.1002/pbc.25405. PMID: 25704363Free PMC Article
Proton radiation therapy for pediatric medulloblastoma and supratentorial primitive neuroectodermal tumors: outcomes for very young children treated with upfront chemotherapy.
Jimenez RB, Sethi R, Depauw N, Pulsifer MB, Adams J, McBride SM, Ebb D, Fullerton BC, Tarbell NJ, Yock TI, Macdonald SM
Int J Radiat Oncol Biol Phys 2013 Sep 1;87(1):120-6. Epub 2013 Jun 21 doi: 10.1016/j.ijrobp.2013.05.017. PMID: 23790826
Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?
Biswas S, Burke A, Cherian S, Williams D, Nicholson J, Horan G, Jefferies S, Williams M, Earl HM, Burnet NG, Hatcher H
Pediatr Blood Cancer 2009 Jul;52(7):796-803. doi: 10.1002/pbc.21899. PMID: 19202566
Application of stem cell transplant for brain tumors.
Gardner SL
Pediatr Transplant 2004 Jun;8 Suppl 5:28-32. doi: 10.1111/j.1398-2265.2004.00202.x. PMID: 15125703
Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy.
Reddy AT, Janss AJ, Phillips PC, Weiss HL, Packer RJ
Cancer 2000 May 1;88(9):2189-93. doi: 10.1002/(sici)1097-0142(20000501)88:9<2189::aid-cncr27>3.0.co;2-g. PMID: 10813733

Prognosis

Pediatric glioblastoma with giant cells and "supratentorial" primitive neuroectodermal component - case report and review of the literature.
Georgiu C, MihuŢ E, Raus I, Mirescu ŞC, Szabo L, Şovrea AS
Rom J Morphol Embryol 2015;56(3):1165-71. PMID: 26662154
Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?
Biswas S, Burke A, Cherian S, Williams D, Nicholson J, Horan G, Jefferies S, Williams M, Earl HM, Burnet NG, Hatcher H
Pediatr Blood Cancer 2009 Jul;52(7):796-803. doi: 10.1002/pbc.21899. PMID: 19202566
A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature.
Ohba S, Yoshida K, Hirose Y, Ikeda E, Kawase T
J Neurooncol 2008 Jan;86(2):217-24. Epub 2007 Aug 23 doi: 10.1007/s11060-007-9466-4. PMID: 17713720
Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report.
Johnston DL, Keene DL, Lafay-Cousin L, Steinbok P, Sung L, Carret AS, Crooks B, Strother D, Wilson B, Odame I, Eisenstat DD, Mpofu C, Zelcer S, Huang A, Bouffet E
J Neurooncol 2008 Jan;86(1):101-8. Epub 2007 Jul 10 doi: 10.1007/s11060-007-9440-1. PMID: 17619825
Pineal and nonpineal supratentorial primitive neuroectodermal tumors.
Jakacki RI
Childs Nerv Syst 1999 Oct;15(10):586-91. doi: 10.1007/s003810050547. PMID: 10550590

Clinical prediction guides

High frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan.
Amayiri N, Tabori U, Campbell B, Bakry D, Aronson M, Durno C, Rakopoulos P, Malkin D, Qaddoumi I, Musharbash A, Swaidan M, Bouffet E, Hawkins C, Al-Hussaini M; BMMRD Consortium
Int J Cancer 2016 Jan 15;138(2):380-5. Epub 2015 Aug 21 doi: 10.1002/ijc.29724. PMID: 26293621
Relapse patterns in pediatric embryonal central nervous system tumors.
Perreault S, Lober RM, Carret AS, Zhang G, Hershon L, Décarie JC, Yeom K, Vogel H, Fisher PG, Partap S
J Neurooncol 2013 Nov;115(2):209-15. Epub 2013 Aug 7 doi: 10.1007/s11060-013-1213-4. PMID: 23921420
Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor.
Li M, Lockwood W, Zielenska M, Northcott P, Ra YS, Bouffet E, Yoshimoto M, Rutka JT, Yan H, Taylor MD, Eberhart C, Hawkins CE, Lam W, Squire JA, Huang A
Cancer Genet 2012 May;205(5):220-31. doi: 10.1016/j.cancergen.2012.03.002. PMID: 22682621
Is there a role for high dose chemotherapy with hematopoietic stem cell rescue in patients with relapsed supratentorial PNET?
Raghuram CP, Moreno L, Zacharoulis S
J Neurooncol 2012 Feb;106(3):441-7. Epub 2011 Aug 18 doi: 10.1007/s11060-011-0690-6. PMID: 21850536
Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays.
Kagawa N, Maruno M, Suzuki T, Hashiba T, Hashimoto N, Izumoto S, Yoshimine T
Brain Tumor Pathol 2006 Apr;23(1):41-7. doi: 10.1007/s10014-006-0201-1. PMID: 18095118

Recent systematic reviews

Is there a role for high dose chemotherapy with hematopoietic stem cell rescue in patients with relapsed supratentorial PNET?
Raghuram CP, Moreno L, Zacharoulis S
J Neurooncol 2012 Feb;106(3):441-7. Epub 2011 Aug 18 doi: 10.1007/s11060-011-0690-6. PMID: 21850536

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