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Weak anal sphincter tone

MedGen UID:
1783328
•Concept ID:
C5543475
•
Finding
HPO: HP:0034917

Definition

Reduced muscle tone of the sphincter of the anus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWeak anal sphincter tone

Professional guidelines

PubMed

Drug treatment for faecal incontinence in adults.
Omar MI, Alexander CE
Cochrane Database Syst Rev 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2. PMID: 23757096Free PMC Article

Recent clinical studies

Etiology

Fishing for (in)continence: long-term follow-up of women with OASIS-still a taboo.
Schütze S, Hohlfeld B, Friedl TWP, Otto S, Kraft K, Hancke K, Hüner B, Janni W, Deniz M
Arch Gynecol Obstet 2021 Apr;303(4):987-997. Epub 2020 Dec 1 doi: 10.1007/s00404-020-05878-8. PMID: 33258994Free PMC Article
A double-blind, placebo-controlled, randomised, parallel-group, dose-escalating, repeat dose study in healthy volunteers to evaluate the safety, tolerability, pharmacodynamic effects and pharmacokinetics of the once daily rectal application of NRL001 suppositories for 14 days.
Bell D, Duffin A, Jacobs A, Pediconi C, Gruss HJ
Colorectal Dis 2014 Mar;16 Suppl 1:36-50. doi: 10.1111/codi.12544. PMID: 24499495
Drug treatment for faecal incontinence in adults.
Omar MI, Alexander CE
Cochrane Database Syst Rev 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2. PMID: 23757096Free PMC Article
Impaired internal anal sphincter in a subgroup of patients with idiopathic fecal incontinence.
Sun WM, Read NW, Donnelly TC
Gastroenterology 1989 Jul;97(1):130-5. doi: 10.1016/0016-5085(89)91425-x. PMID: 2721866
Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients.
Read NW, Haynes WG, Bartolo DC, Hall J, Read MG, Donnelly TC, Johnson AG
Gastroenterology 1983 Jul;85(1):105-13. PMID: 6852445

Diagnosis

Fishing for (in)continence: long-term follow-up of women with OASIS-still a taboo.
Schütze S, Hohlfeld B, Friedl TWP, Otto S, Kraft K, Hancke K, Hüner B, Janni W, Deniz M
Arch Gynecol Obstet 2021 Apr;303(4):987-997. Epub 2020 Dec 1 doi: 10.1007/s00404-020-05878-8. PMID: 33258994Free PMC Article
Anorectal malformation in an adult: a case report.
Ogundoyin OO, Afuwape OO, Olulana DI, Lawal TA
Afr J Med Med Sci 2013 Dec;42(4):359-60. PMID: 24839741
Treatment of primary bladder neck obstruction in women with transurethral resection of the bladder neck.
Blaivas JG, Flisser A, Tash JA
J Urol 2004 Mar;171(3):1172-5. doi: 10.1097/01.ju.0000112929.34864.2c. PMID: 14767294
Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients.
Read NW, Haynes WG, Bartolo DC, Hall J, Read MG, Donnelly TC, Johnson AG
Gastroenterology 1983 Jul;85(1):105-13. PMID: 6852445

Therapy

A double-blind, placebo-controlled, randomised, parallel-group, dose-escalating, repeat dose study in healthy volunteers to evaluate the safety, tolerability, pharmacodynamic effects and pharmacokinetics of the once daily rectal application of NRL001 suppositories for 14 days.
Bell D, Duffin A, Jacobs A, Pediconi C, Gruss HJ
Colorectal Dis 2014 Mar;16 Suppl 1:36-50. doi: 10.1111/codi.12544. PMID: 24499495
Drug treatment for faecal incontinence in adults.
Omar MI, Alexander CE
Cochrane Database Syst Rev 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2. PMID: 23757096Free PMC Article
Topical phenylephrine increases anal canal resting pressure in patients with faecal incontinence.
Cheetham MJ, Kamm MA, Phillips RK
Gut 2001 Mar;48(3):356-9. doi: 10.1136/gut.48.3.356. PMID: 11171825Free PMC Article

Prognosis

Fishing for (in)continence: long-term follow-up of women with OASIS-still a taboo.
Schütze S, Hohlfeld B, Friedl TWP, Otto S, Kraft K, Hancke K, Hüner B, Janni W, Deniz M
Arch Gynecol Obstet 2021 Apr;303(4):987-997. Epub 2020 Dec 1 doi: 10.1007/s00404-020-05878-8. PMID: 33258994Free PMC Article

Clinical prediction guides

Comparing male and female pelvic floor muscle function by the number and type of pelvic floor symptoms.
Notenboom-Nas FJM, Knol-de Vries GE, Slieker-Ten Hove MCP, Dekker JH, Keuken DG, van Koeveringe GA, Blanker MH
Neurourol Urodyn 2023 Apr;42(4):875-885. Epub 2023 Feb 22 doi: 10.1002/nau.25149. PMID: 36811502
Fishing for (in)continence: long-term follow-up of women with OASIS-still a taboo.
Schütze S, Hohlfeld B, Friedl TWP, Otto S, Kraft K, Hancke K, Hüner B, Janni W, Deniz M
Arch Gynecol Obstet 2021 Apr;303(4):987-997. Epub 2020 Dec 1 doi: 10.1007/s00404-020-05878-8. PMID: 33258994Free PMC Article
Drug treatment for faecal incontinence in adults.
Omar MI, Alexander CE
Cochrane Database Syst Rev 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2. PMID: 23757096Free PMC Article
Sympathetic nervous influence on the internal anal sphincter and rectum in man.
Carlstedt A, Nordgren S, Fasth S, Appelgren L, Hultén L
Int J Colorectal Dis 1988 Jun;3(2):90-5. doi: 10.1007/BF01645312. PMID: 3411187
Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients.
Read NW, Haynes WG, Bartolo DC, Hall J, Read MG, Donnelly TC, Johnson AG
Gastroenterology 1983 Jul;85(1):105-13. PMID: 6852445

Recent systematic reviews

Drug treatment for faecal incontinence in adults.
Omar MI, Alexander CE
Cochrane Database Syst Rev 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2. PMID: 23757096Free PMC Article

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