U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Endometrial Clear Cell Adenocarcinoma

MedGen UID:
1783987
•Concept ID:
C5446647
•
Neoplastic Process

Definition

Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Clear Cell Adenocarcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Utility and limitations of abdominal radiotherapy in the management of endometrial carcinomas.
Dusenbery KE, Potish RA, Gold DG, Boente MP
Gynecol Oncol 2005 Mar;96(3):635-42. doi: 10.1016/j.ygyno.2004.11.048. PMID: 15721405
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Recent clinical studies

Etiology

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564
Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma.
Sakuragi N, Hareyama H, Todo Y, Yamada H, Yamamoto R, Fujino T, Sagawa T, Fujimoto S
Acta Obstet Gynecol Scand 2000 Apr;79(4):311-6. PMID: 10746848

Diagnosis

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Therapy

Metastatic clear cell endometrial carcinoma: an unusual cause of a common clinical presentation.
Emiloju O, Candelario N, Dourado C
BMJ Case Rep 2020 Jun 11;13(6) doi: 10.1136/bcr-2020-235051. PMID: 32532916Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Systemic therapy in metastatic or recurrent endometrial cancer.
Pectasides D, Pectasides E, Economopoulos T
Cancer Treat Rev 2007 Apr;33(2):177-90. Epub 2006 Dec 29 doi: 10.1016/j.ctrv.2006.10.007. PMID: 17196749
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Prognosis

Metastatic clear cell endometrial carcinoma: an unusual cause of a common clinical presentation.
Emiloju O, Candelario N, Dourado C
BMJ Case Rep 2020 Jun 11;13(6) doi: 10.1136/bcr-2020-235051. PMID: 32532916Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Clinical prediction guides

Molecular evidence for a clonal relationship between synchronous uterine endometrioid carcinoma and ovarian clear cell carcinoma: a new example of "precursor escape"?
Weng CH, Wu RC, Chen SJ, Chen HC, Tan KT, Lee YS, Huang SS, Yang LY, Wang CJ, Chou HH, Chao AS, Chao A, Lai CH
J Mol Med (Berl) 2021 Jul;99(7):959-966. Epub 2021 Mar 25 doi: 10.1007/s00109-021-02064-4. PMID: 33768299
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Adjuvant therapy in patients with clear cell endometrial carcinoma: An analysis of the National Cancer Database.
Nieto K, Adams W, Pham N, Block AM, Grover S, Small W Jr, Harkenrider MM
Gynecol Oncol 2018 Jan;148(1):147-153. Epub 2017 Nov 10 doi: 10.1016/j.ygyno.2017.11.010. PMID: 29129389
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176

Recent systematic reviews

Histologic Subtypes in Endometriosis-Associated Ovarian Cancer and Ovarian Cancer Arising in Endometriosis: A Systematic Review and Meta-Analysis.
Chiaffarino F, Cipriani S, Ricci E, Esposito G, Parazzini F, Vercellini P
Reprod Sci 2024 Jun;31(6):1642-1650. Epub 2024 Mar 4 doi: 10.1007/s43032-024-01489-9. PMID: 38438776Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...