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Increased circulating inosine concentration

MedGen UID:
1784908
•Concept ID:
C5539526
•
Finding
HPO: HP:0033339

Definition

An increased concentration of inosine in the blood circulation. [from HPO]

Conditions with this feature

Purine-nucleoside phosphorylase deficiency
MedGen UID:
75653
•Concept ID:
C0268125
•
Disease or Syndrome
Purine nucleoside phosphorylase deficiency is a rare autosomal recessive immunodeficiency disorder characterized mainly by decreased T-cell function. Some patients also have neurologic impairment (review by Aust et al., 1992).
See: Condition Record
Purine-nucleoside phosphorylase deficiency

Recent clinical studies

Etiology

Population pharmacokinetics and pharmacodynamics of mycophenolic acid using the prospective data in patients undergoing hematopoietic stem cell transplantation.
Yoshimura K, Yano I, Yamamoto T, Kawanishi M, Isomoto Y, Yonezawa A, Kondo T, Takaori-Kondo A, Matsubara K
Bone Marrow Transplant 2018 Jan;53(1):44-51. Epub 2017 Oct 9 doi: 10.1038/bmt.2017.213. PMID: 28991252
Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis.
Pettengill M, Matute JD, Tresenriter M, Hibbert J, Burgner D, Richmond P, Millán JL, Ozonoff A, Strunk T, Currie A, Levy O
PLoS One 2017;12(4):e0175936. Epub 2017 Apr 27 doi: 10.1371/journal.pone.0175936. PMID: 28448526Free PMC Article
Protective mechanisms of inosine in platelet activation and cerebral ischemic damage.
Hsiao G, Lin KH, Chang Y, Chen TL, Tzu NH, Chou DS, Sheu JR
Arterioscler Thromb Vasc Biol 2005 Sep;25(9):1998-2004. Epub 2005 Jun 23 doi: 10.1161/01.ATV.0000174798.25085.d6. PMID: 15976325
Ontogeny of adenosine production and degradation and its implications in neonatal cerebral blood flow regulation.
Aranda JV, Beharry K, Laudignon N, Sasyniuk BI
Dev Pharmacol Ther 1989;13(2-4):96-103. doi: 10.1159/000457590. PMID: 2693008
Concentration of 2,3-diphosphoglycerate and adenosine triphosphate in erythrocytes following acute blood loss in the beagle.
Zachara B, Zakrzewska I, Maziarz Z, Gaszyński W, Wachowicz N
Haematologia (Budap) 1981;14(3):285-91. PMID: 7327442

Diagnosis

Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis.
Pettengill M, Matute JD, Tresenriter M, Hibbert J, Burgner D, Richmond P, Millán JL, Ozonoff A, Strunk T, Currie A, Levy O
PLoS One 2017;12(4):e0175936. Epub 2017 Apr 27 doi: 10.1371/journal.pone.0175936. PMID: 28448526Free PMC Article
Myocardial release of lactate, inosine and hypoxanthine during atrial pacing and exercise-induced angina.
Kugler G
Circulation 1979 Jan;59(1):43-9. doi: 10.1161/01.cir.59.1.43. PMID: 758123

Therapy

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.
Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto K, Kitagawa H, Ohta T, Tamai I, Sai Y
J Pharm Sci 2015 Sep;104(9):3162-9. Epub 2015 Jun 2 doi: 10.1002/jps.24498. PMID: 26037416
Pharmacodynamics of mycophenolic acid in CD4+ cells: a single-dose study of IMPDH and purine nucleotide responses in healthy individuals.
Vethe NT, Bremer S, Rootwelt H, Bergan S
Ther Drug Monit 2008 Dec;30(6):647-55. doi: 10.1097/FTD.0b013e31818955c3. PMID: 18806697
Relationship between dideoxyinosine exposure, CD4 counts, and p24 antigen levels in human immunodeficiency virus infection. A phase I trial.
Drusano GL, Yuen GJ, Lambert JS, Seidlin M, Dolin R, Valentine FT
Ann Intern Med 1992 Apr 1;116(7):562-6. doi: 10.7326/0003-4819-116-7-562. PMID: 1347442

Clinical prediction guides

Pharmacodynamics of mycophenolic acid in CD4+ cells: a single-dose study of IMPDH and purine nucleotide responses in healthy individuals.
Vethe NT, Bremer S, Rootwelt H, Bergan S
Ther Drug Monit 2008 Dec;30(6):647-55. doi: 10.1097/FTD.0b013e31818955c3. PMID: 18806697
Cardiac surgery: myocardial energy balance, antioxidant status and endothelial function after ischemia-reperfusion.
Carlucci F, Tabucchi A, Biagioli B, Simeone F, Scolletta S, Rosi F, Marinello E
Biomed Pharmacother 2002 Dec;56(10):483-91. doi: 10.1016/s0753-3322(02)00286-x. PMID: 12504269
Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery.
Lazzarino G, Raatikainen P, Nuutinen M, Nissinen J, Tavazzi B, Di Pierro D, Giardina B, Peuhkurinen K
Circulation 1994 Jul;90(1):291-7. doi: 10.1161/01.cir.90.1.291. PMID: 8026011
Energy metabolism in single human muscle fibres during intermittent contraction with occluded circulation.
Greenhaff PL, Söderlund K, Ren JM, Hultman E
J Physiol 1993 Jan;460:443-53. doi: 10.1113/jphysiol.1993.sp019480. PMID: 8487203Free PMC Article
Disparate enzyme activity in erythocytes and leukocytes. A variant of hypoxanthine phosphoribosyl-transferase deficiency with an unstable enzyme.
Dancis J, Yip LC, Cox RP, Piomelli S, Balis ME
J Clin Invest 1973 Aug;52(8):2068-74. doi: 10.1172/JCI107391. PMID: 4352580Free PMC Article

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