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Elevated myocardial native T1

MedGen UID:
1785178
•Concept ID:
C5539858
•
Finding
Synonym: Prolonged myocardial native T1
 
HPO: HP:4000006

Definition

Increased duration of myocardial T1 time without gadolinium contrast. T1 mapping consists of quantifying the T1 relaxation time of a tissue by using analytical expressions of image-based signal intensities. A fundamental principle of MR imaging is that the signal intensity of pixels is based on the relaxation of hydrogen nuclei protons in a static magnetic field. The T1 relaxation times between two tissues vary substantially. Edema, fat infiltration, and fibrosis also cause differences in T1 relaxivity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated myocardial native T1

Professional guidelines

PubMed

CMR imaging biosignature of cardiac involvement due to cancer-related treatment by T1 and T2 mapping.
Haslbauer JD, Lindner S, Valbuena-Lopez S, Zainal H, Zhou H, D'Angelo T, Pathan F, Arendt CA, Bug G, Serve H, Vogl TJ, Zeiher AM, Carr-White G, Nagel E, Puntmann VO
Int J Cardiol 2019 Jan 15;275:179-186. Epub 2018 Oct 11 doi: 10.1016/j.ijcard.2018.10.023. PMID: 30360992

Recent clinical studies

Etiology

Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome.
Singh T, Joshi S, Kershaw LE, Baker AH, McCann GP, Dawson DK, Dweck MR, Semple SI, Newby DE
Circulation 2022 Dec 13;146(24):1823-1835. Epub 2022 Nov 1 doi: 10.1161/CIRCULATIONAHA.122.060375. PMID: 36317524Free PMC Article
Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.
Graham-Brown MPM, Gulsin GS, Poli F, Parke K, Burton JO, McCann GP
Eur J Radiol 2021 Jul;140:109748. Epub 2021 May 1 doi: 10.1016/j.ejrad.2021.109748. PMID: 33962255
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Native T1 and Extracellular Volume in Transthyretin Amyloidosis.
Martinez-Naharro A, Kotecha T, Norrington K, Boldrini M, Rezk T, Quarta C, Treibel TA, Whelan CJ, Knight DS, Kellman P, Ruberg FL, Gillmore JD, Moon JC, Hawkins PN, Fontana M
JACC Cardiovasc Imaging 2019 May;12(5):810-819. Epub 2018 Mar 14 doi: 10.1016/j.jcmg.2018.02.006. PMID: 29550324
Native myocardial T1 mapping in pulmonary hypertension: correlations with cardiac function and hemodynamics.
Reiter U, Reiter G, Kovacs G, Adelsmayr G, Greiser A, Olschewski H, Fuchsjäger M
Eur Radiol 2017 Jan;27(1):157-166. Epub 2016 Apr 27 doi: 10.1007/s00330-016-4360-0. PMID: 27121929Free PMC Article

Diagnosis

Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.
Kaolawanich Y, Azevedo CF, Kim HW, Jenista ER, Wendell DC, Chen EL, Parker MA, Judd RM, Kim RJ
JACC Cardiovasc Imaging 2022 Dec;15(12):2069-2079. Epub 2022 Nov 16 doi: 10.1016/j.jcmg.2022.09.011. PMID: 36481075
Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome.
Singh T, Joshi S, Kershaw LE, Baker AH, McCann GP, Dawson DK, Dweck MR, Semple SI, Newby DE
Circulation 2022 Dec 13;146(24):1823-1835. Epub 2022 Nov 1 doi: 10.1161/CIRCULATIONAHA.122.060375. PMID: 36317524Free PMC Article
Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.
Graham-Brown MPM, Gulsin GS, Poli F, Parke K, Burton JO, McCann GP
Eur J Radiol 2021 Jul;140:109748. Epub 2021 May 1 doi: 10.1016/j.ejrad.2021.109748. PMID: 33962255
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Native T1 and Extracellular Volume in Transthyretin Amyloidosis.
Martinez-Naharro A, Kotecha T, Norrington K, Boldrini M, Rezk T, Quarta C, Treibel TA, Whelan CJ, Knight DS, Kellman P, Ruberg FL, Gillmore JD, Moon JC, Hawkins PN, Fontana M
JACC Cardiovasc Imaging 2019 May;12(5):810-819. Epub 2018 Mar 14 doi: 10.1016/j.jcmg.2018.02.006. PMID: 29550324

Therapy

Comprehensive cardiac magnetic resonance T1, T2, and extracellular volume mapping to define Duchenne cardiomyopathy.
Sunthankar SD, George-Durrett K, Crum K, Slaughter JC, Kasten J, Raucci FJ Jr, Markham LW, Soslow JH
J Cardiovasc Magn Reson 2023 Jul 31;25(1):44. doi: 10.1186/s12968-023-00951-y. PMID: 37517994Free PMC Article
Comprehensive Cardiovascular Magnetic Resonance Tissue Characterization and Cardiotoxicity in Women With Breast Cancer.
Thavendiranathan P, Shalmon T, Fan CS, Houbois C, Amir E, Thevakumaran Y, Somerset E, Malowany JM, Urzua-Fresno C, Yip P, McIntosh C, Sussman MS, Brezden-Masley C, Yan AT, Koch CA, Spiller N, Abdel-Qadir H, Power C, Hanneman K, Wintersperger BJ
JAMA Cardiol 2023 Jun 1;8(6):524-534. doi: 10.1001/jamacardio.2023.0494. PMID: 37043251Free PMC Article
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Thavendiranathan P, Zhang L, Zafar A, Drobni ZD, Mahmood SS, Cabral M, Awadalla M, Nohria A, Zlotoff DA, Thuny F, Heinzerling LM, Barac A, Sullivan RJ, Chen CL, Gupta D, Kirchberger MC, Hartmann SE, Weinsaft JW, Gilman HK, Rizvi MA, Kovacina B, Michel C, Sahni G, González-Mansilla A, Calles A, Fernández-Avilés F, Mahmoudi M, Reynolds KL, Ganatra S, Gavira JJ, González NS, García de Yébenes Castro M, Kwong RY, Jerosch-Herold M, Coelho-Filho OR, Afilalo J, Zataraín-Nicolás E, Baksi AJ, Wintersperger BJ, Calvillo-Arguelles O, Ederhy S, Yang EH, Lyon AR, Fradley MG, Neilan TG
J Am Coll Cardiol 2021 Mar 30;77(12):1503-1516. doi: 10.1016/j.jacc.2021.01.050. PMID: 33766256Free PMC Article
Effect of anthracycline therapy on myocardial function and markers of fibrotic remodelling in childhood cancer survivors.
Mawad W, Mertens L, Pagano JJ, Riesenkampff E, Reichert MJE, Mital S, Kantor PF, Greenberg M, Liu P, Nathan PC, Grosse-Wortmann L
Eur Heart J Cardiovasc Imaging 2021 Mar 22;22(4):435-442. doi: 10.1093/ehjci/jeaa093. PMID: 32535624Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article

Prognosis

Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.
Kaolawanich Y, Azevedo CF, Kim HW, Jenista ER, Wendell DC, Chen EL, Parker MA, Judd RM, Kim RJ
JACC Cardiovasc Imaging 2022 Dec;15(12):2069-2079. Epub 2022 Nov 16 doi: 10.1016/j.jcmg.2022.09.011. PMID: 36481075
Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.
Graham-Brown MPM, Gulsin GS, Poli F, Parke K, Burton JO, McCann GP
Eur J Radiol 2021 Jul;140:109748. Epub 2021 May 1 doi: 10.1016/j.ejrad.2021.109748. PMID: 33962255
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Native T1 and Extracellular Volume in Transthyretin Amyloidosis.
Martinez-Naharro A, Kotecha T, Norrington K, Boldrini M, Rezk T, Quarta C, Treibel TA, Whelan CJ, Knight DS, Kellman P, Ruberg FL, Gillmore JD, Moon JC, Hawkins PN, Fontana M
JACC Cardiovasc Imaging 2019 May;12(5):810-819. Epub 2018 Mar 14 doi: 10.1016/j.jcmg.2018.02.006. PMID: 29550324
Native myocardial T1 mapping in pulmonary hypertension: correlations with cardiac function and hemodynamics.
Reiter U, Reiter G, Kovacs G, Adelsmayr G, Greiser A, Olschewski H, Fuchsjäger M
Eur Radiol 2017 Jan;27(1):157-166. Epub 2016 Apr 27 doi: 10.1007/s00330-016-4360-0. PMID: 27121929Free PMC Article

Clinical prediction guides

Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.
Kaolawanich Y, Azevedo CF, Kim HW, Jenista ER, Wendell DC, Chen EL, Parker MA, Judd RM, Kim RJ
JACC Cardiovasc Imaging 2022 Dec;15(12):2069-2079. Epub 2022 Nov 16 doi: 10.1016/j.jcmg.2022.09.011. PMID: 36481075
Differences in native T1 and native T2 mapping between patients on hemodialysis and control subjects.
Graham-Brown MPM, Gulsin GS, Poli F, Parke K, Burton JO, McCann GP
Eur J Radiol 2021 Jul;140:109748. Epub 2021 May 1 doi: 10.1016/j.ejrad.2021.109748. PMID: 33962255
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Clinical impact of native T1 mapping for detecting myocardial impairment in takotsubo cardiomyopathy.
Aikawa Y, Noguchi T, Morita Y, Tateishi E, Kono A, Miura H, Komori Y, Asaumi Y, Fukuda T, Yasuda S
Eur Heart J Cardiovasc Imaging 2019 Oct 1;20(10):1147-1155. doi: 10.1093/ehjci/jez034. PMID: 30879048
Native T1 and Extracellular Volume in Transthyretin Amyloidosis.
Martinez-Naharro A, Kotecha T, Norrington K, Boldrini M, Rezk T, Quarta C, Treibel TA, Whelan CJ, Knight DS, Kellman P, Ruberg FL, Gillmore JD, Moon JC, Hawkins PN, Fontana M
JACC Cardiovasc Imaging 2019 May;12(5):810-819. Epub 2018 Mar 14 doi: 10.1016/j.jcmg.2018.02.006. PMID: 29550324

Recent systematic reviews

Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis.
Mohamed AA, Elmancy LY, Abulola SM, Al-Qattan SA, Mohamed Ibrahim MI, Maayah ZH
Cardiovasc Toxicol 2024 Jun;24(6):563-575. Epub 2024 May 3 doi: 10.1007/s12012-024-09866-1. PMID: 38700665Free PMC Article

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