U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Distant Metastasis

MedGen UID:
1785231
Concept ID:
C5441917
Pathologic Function
Synonym: Distant Cancer

Definition

A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDistant Metastasis

Professional guidelines

PubMed

Gauci ML, Aristei C, Becker JC, Blom A, Bataille V, Dreno B, Del Marmol V, Forsea AM, Fargnoli MC, Grob JJ, Gomes F, Hauschild A, Hoeller C, Harwood C, Kelleners-Smeets N, Kaufmann R, Lallas A, Malvehy J, Moreno-Ramirez D, Peris K, Pellacani G, Saiag P, Stratigos AJ, Vieira R, Zalaudek I, van Akkooi ACJ, Lorigan P, Garbe C, Lebbé C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Aug;171:203-231. Epub 2022 Jun 19 doi: 10.1016/j.ejca.2022.03.043. PMID: 35732101
Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673Free PMC Article

Recent clinical studies

Etiology

Nakano Y, Kagawa Y, Shimoyama Y, Yamagami T, Nomura K, Wakabayashi H, Sugiyama Y, Kobayashi T
J Am Vet Med Assoc 2021 Dec 15;260(S1):S24-S28. doi: 10.2460/javma.21.04.0213. PMID: 34914624
Wang C, Xu K, Wang R, Han X, Tang J, Guan X
J Exp Clin Cancer Res 2021 Nov 20;40(1):370. doi: 10.1186/s13046-021-02164-6. PMID: 34801088Free PMC Article
Lee TL, Liao YH, Liau JY, Sheen YS
Sci Rep 2021 Oct 25;11(1):21012. doi: 10.1038/s41598-021-00386-4. PMID: 34697327Free PMC Article
Chen B, Zeng Y, Liu B, Lu G, Xiang Z, Chen J, Yu Y, Zuo Z, Lin Y, Ma J
Front Endocrinol (Lausanne) 2021;12:672024. Epub 2021 Jul 30 doi: 10.3389/fendo.2021.672024. PMID: 34393996Free PMC Article
Chiesa-Estomba CM, Lechien JR, Ayad T, Calvo-Henriquez C, González-García JÁ, Sistiaga-Suarez JA, Dequanter D, Fakhry N, Melesse G, Piazza C
Acta Otorhinolaryngol Ital 2021 Feb;41(1):6-17. doi: 10.14639/0392-100X-N0879. PMID: 33746217Free PMC Article

Diagnosis

Li F, Xu T, Chen P, Sun R, Li C, Zhao X, Ou J, Li J, Liu T, Zeng M, Zheng W, Lin Y, Yang L, Li Z, Chen H, Zhang Q
Int J Biol Sci 2022;18(15):5858-5872. Epub 2022 Sep 24 doi: 10.7150/ijbs.76162. PMID: 36263165Free PMC Article
Chen B, Zeng Y, Liu B, Lu G, Xiang Z, Chen J, Yu Y, Zuo Z, Lin Y, Ma J
Front Endocrinol (Lausanne) 2021;12:672024. Epub 2021 Jul 30 doi: 10.3389/fendo.2021.672024. PMID: 34393996Free PMC Article
Pisani P, Airoldi M, Allais A, Aluffi Valletti P, Battista M, Benazzo M, Briatore R, Cacciola S, Cocuzza S, Colombo A, Conti B, Costanzo A, Della Vecchia L, Denaro N, Fantozzi C, Galizia D, Garzaro M, Genta I, Iasi GA, Krengli M, Landolfo V, Lanza GV, Magnano M, Mancuso M, Maroldi R, Masini L, Merlano MC, Piemonte M, Pisani S, Prina-Mello A, Prioglio L, Rugiu MG, Scasso F, Serra A, Valente G, Zannetti M, Zigliani A
Acta Otorhinolaryngol Ital 2020 Apr;40(SUPPL. 1):S1-S86. doi: 10.14639/0392-100X-suppl.1-40-2020. PMID: 32469009Free PMC Article
Aleshawi AJ, Allouh MZ, Heis FH, Tashtush N, Heis HA
J Gastrointest Cancer 2020 Jun;51(2):433-438. doi: 10.1007/s12029-019-00282-1. PMID: 31392629
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165

Therapy

Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
Murthy V, Maitre P, Kannan S, Panigrahi G, Krishnatry R, Bakshi G, Prakash G, Pal M, Menon S, Phurailatpam R, Mokal S, Chaurasiya D, Popat P, Sable N, Agarwal A, Rangarajan V, Joshi A, Noronha V, Prabhash K, Mahantshetty U
J Clin Oncol 2021 Apr 10;39(11):1234-1242. Epub 2021 Jan 26 doi: 10.1200/JCO.20.03282. PMID: 33497252
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, Kurata T, Chiappori A, Lee KH, de Wit M, Cho BC, Bourhaba M, Quantin X, Tokito T, Mekhail T, Planchard D, Kim YC, Karapetis CS, Hiret S, Ostoros G, Kubota K, Gray JE, Paz-Ares L, de Castro Carpeño J, Faivre-Finn C, Reck M, Vansteenkiste J, Spigel DR, Wadsworth C, Melillo G, Taboada M, Dennis PA, Özgüroğlu M; PACIFIC Investigators
N Engl J Med 2018 Dec 13;379(24):2342-2350. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1809697. PMID: 30280658
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, Yokoi T, Chiappori A, Lee KH, de Wit M, Cho BC, Bourhaba M, Quantin X, Tokito T, Mekhail T, Planchard D, Kim YC, Karapetis CS, Hiret S, Ostoros G, Kubota K, Gray JE, Paz-Ares L, de Castro Carpeño J, Wadsworth C, Melillo G, Jiang H, Huang Y, Dennis PA, Özgüroğlu M; PACIFIC Investigators
N Engl J Med 2017 Nov 16;377(20):1919-1929. Epub 2017 Sep 8 doi: 10.1056/NEJMoa1709937. PMID: 28885881

Prognosis

McGarrah PW, Westin GFM, Hobday TJ, Scales JA, Ingimarsson JP, Leibovich BC, Halfdanarson TR
Clin Genitourin Cancer 2020 Aug;18(4):e343-e349. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.003. PMID: 31911122
Owusu-Ansah KG, Song G, Chen R, Edoo MIA, Li J, Chen B, Wu J, Zhou L, Xie H, Jiang D, Zheng S
Int J Oncol 2019 Aug;55(2):391-404. Epub 2019 Jun 14 doi: 10.3892/ijo.2019.4825. PMID: 31268154Free PMC Article
Ito Y, Miyauchi A
Annu Rev Med 2019 Jan 27;70:369-379. Epub 2018 Sep 19 doi: 10.1146/annurev-med-051517-125510. PMID: 30230964
Kishan AU, Cook RR, Ciezki JP, Ross AE, Pomerantz MM, Nguyen PL, Shaikh T, Tran PT, Sandler KA, Stock RG, Merrick GS, Demanes DJ, Spratt DE, Abu-Isa EI, Wedde TB, Lilleby W, Krauss DJ, Shaw GK, Alam R, Reddy CA, Stephenson AJ, Klein EA, Song DY, Tosoian JJ, Hegde JV, Yoo SM, Fiano R, D'Amico AV, Nickols NG, Aronson WJ, Sadeghi A, Greco S, Deville C, McNutt T, DeWeese TL, Reiter RE, Said JW, Steinberg ML, Horwitz EM, Kupelian PA, King CR
JAMA 2018 Mar 6;319(9):896-905. doi: 10.1001/jama.2018.0587. PMID: 29509865Free PMC Article
Takes RP, Rinaldo A, Silver CE, Haigentz M Jr, Woolgar JA, Triantafyllou A, Mondin V, Paccagnella D, de Bree R, Shaha AR, Hartl DM, Ferlito A
Oral Oncol 2012 Sep;48(9):775-9. Epub 2012 Apr 18 doi: 10.1016/j.oraloncology.2012.03.013. PMID: 22520054

Clinical prediction guides

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Tian L, Zhang D, Bao S, Nie P, Hao D, Liu Y, Zhang J, Wang H
Clin Radiol 2021 Feb;76(2):158.e19-158.e25. Epub 2020 Dec 5 doi: 10.1016/j.crad.2020.08.038. PMID: 33293024
Lu H, Liu H, Yang X, Ye T, Lv P, Wu X, Ye Z
Biomed Res Int 2019;2019:1275491. Epub 2019 Apr 2 doi: 10.1155/2019/1275491. PMID: 31061820Free PMC Article
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Liu HS, Xiao HS
World J Gastroenterol 2014 Sep 14;20(34):12007-17. doi: 10.3748/wjg.v20.i34.12007. PMID: 25232237Free PMC Article

Recent systematic reviews

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Baretta Z, Mocellin S, Goldin E, Olopade OI, Huo D
Medicine (Baltimore) 2016 Oct;95(40):e4975. doi: 10.1097/MD.0000000000004975. PMID: 27749552Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...