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Recurrent Anal Canal Squamous Cell Carcinoma

MedGen UID:
1786287
•Concept ID:
C5446468
•
Neoplastic Process

Definition

The reemergence of anal canal squamous cell carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Anal Canal Squamous Cell Carcinoma

Professional guidelines

PubMed

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
Follow-up imaging of anal cancer after treatment.
El Homsi M, Sheedy SP, Rauch GM, Ganeshan DM, Ernst RD, Golia Pernicka JS
Abdom Radiol (NY) 2023 Sep;48(9):2888-2897. Epub 2023 Apr 6 doi: 10.1007/s00261-023-03895-0. PMID: 37024606
Treatment of the Primary Tumor in Anal Canal Cancers.
Glynne-Jones R, Rao S
Surg Oncol Clin N Am 2017 Jan;26(1):73-90. doi: 10.1016/j.soc.2016.07.003. PMID: 27889038

Recent clinical studies

Etiology

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Definitive chemoradiation in nonmetastatic squamous cell carcinoma anal canal: A single-institution experience.
Kumar V, Bansal S, Badola A, Nautiyal V, Gupta M, Ahmad M, Saini S
J Cancer Res Ther 2022 Dec;18(Supplement):S405-S409. doi: 10.4103/jcrt.JCRT_979_20. PMID: 36510995
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Locally Recurrent Disease Related to Anal Canal Cancers.
Sammour T, Rodriguez-Bigas MA, Skibber JM
Surg Oncol Clin N Am 2017 Jan;26(1):115-125. doi: 10.1016/j.soc.2016.07.006. PMID: 27889030

Diagnosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Definitive chemoradiation in nonmetastatic squamous cell carcinoma anal canal: A single-institution experience.
Kumar V, Bansal S, Badola A, Nautiyal V, Gupta M, Ahmad M, Saini S
J Cancer Res Ther 2022 Dec;18(Supplement):S405-S409. doi: 10.4103/jcrt.JCRT_979_20. PMID: 36510995
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Squamous cell carcinoma of the anal margin treated with radiotherapy.
Mendenhall WM, Zlotecki RA, Vauthey JN, Copeland EM 3rd
Surg Oncol 1996 Feb;5(1):29-35. PMID: 8837302
Squamous-cell carcinoma of the anal canal.
Gordon PH
Surg Clin North Am 1988 Dec;68(6):1391-9. doi: 10.1016/s0039-6109(16)44694-3. PMID: 3057665

Prognosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Squamous cell carcinoma of the anal canal.
Morton M, Melnitchouk N, Bleday R
Curr Probl Cancer 2018 Sep;42(5):486-492. Epub 2018 Nov 23 doi: 10.1016/j.currproblcancer.2018.11.001. PMID: 30497849
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Surgical management of anal cancer.
Gilshtein H, Khoury W
Minerva Chir 2015 Apr;70(2):141-5. Epub 2015 Feb 18 PMID: 25690347
Squamous cell carcinoma of the anal canal: a review of the aetiology, presentation, staging, prognosis and methods available for treatment.
Szmulowicz UM, Wu JS
Sex Health 2012 Dec;9(6):593-609. doi: 10.1071/SH12010. PMID: 22951027

Clinical prediction guides

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Definitive chemoradiation in nonmetastatic squamous cell carcinoma anal canal: A single-institution experience.
Kumar V, Bansal S, Badola A, Nautiyal V, Gupta M, Ahmad M, Saini S
J Cancer Res Ther 2022 Dec;18(Supplement):S405-S409. doi: 10.4103/jcrt.JCRT_979_20. PMID: 36510995
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Anal cancer and precancerous lesions: a call for improvement.
Albuquerque A, Nathan M, Cappello C, Dinis-Ribeiro M
Lancet Gastroenterol Hepatol 2021 Apr;6(4):327-334. doi: 10.1016/S2468-1253(20)30304-6. PMID: 33714370
Anal squamous cell carcinoma: are we improving outcomes?
Mackowski A, Levitt M, Makin G, Salama P, Tan P, Penter C, Platell C
ANZ J Surg 2018 Oct;88(10):1013-1016. Epub 2018 Aug 29 doi: 10.1111/ans.14745. PMID: 30159994

Recent systematic reviews

Assessing Circulating Tumour DNA (ctDNA) as a Biomarker for Anal Cancer Management: A Systematic Review.
Temperley HC, Fannon T, O'Sullivan NJ, O'Neill M, Mac Curtain BM, Gilham C, O'Sullivan J, O'Kane G, Mehigan BJ, O'Toole S, Larkin JO, Gallagher D, McCormick P, Kelly ME
Int J Mol Sci 2024 Apr 3;25(7) doi: 10.3390/ijms25074005. PMID: 38612815Free PMC Article
Outcome following local excision of T1 anal cancers-a systematic review.
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458

Supplemental Content

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