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Abnormal KCO

MedGen UID:
1786388
•Concept ID:
C5539542
•
Finding
HPO: HP:0033372

Definition

Any deviation from the normal range of KCO. The KCO is a measurement of the rate constant for alveolar uptake of CO during breath-holding in the single breath measurement of DLCO at full inflation. The DLCO is derived as the product of the KCO and the single breath alveolar volume (VA) divided by PB-PH2O. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal KCO

Professional guidelines

PubMed

Measurement of lysosomal enzyme activities: A technical standard of the American College of Medical Genetics and Genomics (ACMG).
Strovel ET, Cusmano-Ozog K, Wood T, Yu C; ACMG Laboratory Quality Assurance Committee. Electronic address: documents@acmg.net
Genet Med 2022 Apr;24(4):769-783. Epub 2022 Feb 10 doi: 10.1016/j.gim.2021.12.013. PMID: 35394426

Recent clinical studies

Etiology

Obesity-related Changes in Diffusing Capacity and Transfer Coefficient of the Lung for Carbon Monoxide and Resulting Patterns of Abnormality across Reference Equations.
Holley AB, Carbone T, Holtzclaw AW, Huprikar NA, Wagner R, Morris MJ
Ann Am Thorac Soc 2023 Jul;20(7):969-975. doi: 10.1513/AnnalsATS.202207-640OC. PMID: 36763964
Neurophysiological mechanisms of exertional dyspnea in post-pulmonary embolism syndrome.
Milne KM, James MD, Smyth RM, Vincent SG, Singh N, D'Arsigny CL, de-Torres JP, de Wit K, Johri A, Neder JA, O'Donnell DE, Phillips DB
J Appl Physiol (1985) 2023 Mar 1;134(3):667-677. Epub 2023 Jan 26 doi: 10.1152/japplphysiol.00677.2022. PMID: 36701483
Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study.
Phillips DB, Elbehairy AF, James MD, Vincent SG, Milne KM, de-Torres JP, Neder JA, Kirby M, Jensen D, Stickland MK, Guenette JA, Smith BM, Aaron SD, Tan WC, Bourbeau J, O'Donnell DE; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network
Am J Respir Crit Care Med 2022 Jun 15;205(12):1391-1402. doi: 10.1164/rccm.202109-2171OC. PMID: 35333135
Early respiratory diagnosis: benefits of enhanced lung function assessment.
Sylvester KP, Youngs L, Rutter MA, Beech R, Mahadeva R
BMJ Open Respir Res 2021 Jul;8(1) doi: 10.1136/bmjresp-2021-001012. PMID: 34312255Free PMC Article
Post-discharge chest CT findings and pulmonary function tests in severe COVID-19 patients.
Balbi M, Conti C, Imeri G, Caroli A, Surace A, Corsi A, Mercanzin E, Arrigoni A, Villa G, Di Marco F, Bonaffini PA, Sironi S
Eur J Radiol 2021 May;138:109676. Epub 2021 Mar 20 doi: 10.1016/j.ejrad.2021.109676. PMID: 33798931Free PMC Article

Diagnosis

Obesity-related Changes in Diffusing Capacity and Transfer Coefficient of the Lung for Carbon Monoxide and Resulting Patterns of Abnormality across Reference Equations.
Holley AB, Carbone T, Holtzclaw AW, Huprikar NA, Wagner R, Morris MJ
Ann Am Thorac Soc 2023 Jul;20(7):969-975. doi: 10.1513/AnnalsATS.202207-640OC. PMID: 36763964
Measurement of lysosomal enzyme activities: A technical standard of the American College of Medical Genetics and Genomics (ACMG).
Strovel ET, Cusmano-Ozog K, Wood T, Yu C; ACMG Laboratory Quality Assurance Committee. Electronic address: documents@acmg.net
Genet Med 2022 Apr;24(4):769-783. Epub 2022 Feb 10 doi: 10.1016/j.gim.2021.12.013. PMID: 35394426
Early respiratory diagnosis: benefits of enhanced lung function assessment.
Sylvester KP, Youngs L, Rutter MA, Beech R, Mahadeva R
BMJ Open Respir Res 2021 Jul;8(1) doi: 10.1136/bmjresp-2021-001012. PMID: 34312255Free PMC Article
Early lung function abnormalities in acromegaly.
Benfante A, Ciresi A, Bellia M, Cannizzaro F, Bellia V, Giordano C, Scichilone N
Lung 2015 Jun;193(3):393-9. Epub 2015 Mar 11 doi: 10.1007/s00408-015-9710-1. PMID: 25757541
Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency.
Holme J, Stockley RA
Chest 2007 Sep;132(3):909-15. Epub 2007 Jun 15 doi: 10.1378/chest.07-0341. PMID: 17573491

Therapy

Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study.
Phillips DB, Elbehairy AF, James MD, Vincent SG, Milne KM, de-Torres JP, Neder JA, Kirby M, Jensen D, Stickland MK, Guenette JA, Smith BM, Aaron SD, Tan WC, Bourbeau J, O'Donnell DE; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network
Am J Respir Crit Care Med 2022 Jun 15;205(12):1391-1402. doi: 10.1164/rccm.202109-2171OC. PMID: 35333135
Determinants of exercise capacity in school-aged esophageal atresia patients.
Toussaint-Duyster LCC, van der Cammen-van Zijp MHM, Spoel M, Lam M, Wijnen RMH, de Jongste JC, Tibboel D, van Rosmalen J, IJsselstijn H
Pediatr Pulmonol 2017 Sep;52(9):1198-1205. Epub 2017 Feb 28 doi: 10.1002/ppul.23687. PMID: 28244688
Aging-related systemic manifestations in COPD patients and cigarette smokers.
Boyer L, Chouaïd C, Bastuji-Garin S, Marcos E, Margarit L, Le Corvoisier P, Vervoitte L, Hamidou L, Frih L, Audureau E, Covali-Noroc A, Andujar P, Saakashvili Z, Lino A, Ghaleh B, Hue S, Derumeaux G, Housset B, Dubois-Randé JL, Boczkowski J, Maitre B, Adnot S
PLoS One 2015;10(3):e0121539. Epub 2015 Mar 18 doi: 10.1371/journal.pone.0121539. PMID: 25785739Free PMC Article
Neutrophilic asthma has different radiographic features to COPD and smokers.
Simpson JL, Milne DG, Gibson PG
Respir Med 2009 Jun;103(6):881-7. Epub 2009 Jan 24 doi: 10.1016/j.rmed.2008.12.013. PMID: 19168339
Cadmium fume inhalation and emphysema.
Davison AG, Fayers PM, Taylor AJ, Venables KM, Darbyshire J, Pickering CA, Chettle DR, Franklin D, Guthrie CJ, Scott MC
Lancet 1988 Mar 26;1(8587):663-7. doi: 10.1016/s0140-6736(88)91474-2. PMID: 2895211

Prognosis

Obesity-related Changes in Diffusing Capacity and Transfer Coefficient of the Lung for Carbon Monoxide and Resulting Patterns of Abnormality across Reference Equations.
Holley AB, Carbone T, Holtzclaw AW, Huprikar NA, Wagner R, Morris MJ
Ann Am Thorac Soc 2023 Jul;20(7):969-975. doi: 10.1513/AnnalsATS.202207-640OC. PMID: 36763964
Post-discharge chest CT findings and pulmonary function tests in severe COVID-19 patients.
Balbi M, Conti C, Imeri G, Caroli A, Surace A, Corsi A, Mercanzin E, Arrigoni A, Villa G, Di Marco F, Bonaffini PA, Sironi S
Eur J Radiol 2021 May;138:109676. Epub 2021 Mar 20 doi: 10.1016/j.ejrad.2021.109676. PMID: 33798931Free PMC Article
Aging-related systemic manifestations in COPD patients and cigarette smokers.
Boyer L, Chouaïd C, Bastuji-Garin S, Marcos E, Margarit L, Le Corvoisier P, Vervoitte L, Hamidou L, Frih L, Audureau E, Covali-Noroc A, Andujar P, Saakashvili Z, Lino A, Ghaleh B, Hue S, Derumeaux G, Housset B, Dubois-Randé JL, Boczkowski J, Maitre B, Adnot S
PLoS One 2015;10(3):e0121539. Epub 2015 Mar 18 doi: 10.1371/journal.pone.0121539. PMID: 25785739Free PMC Article
Early lung function abnormalities in acromegaly.
Benfante A, Ciresi A, Bellia M, Cannizzaro F, Bellia V, Giordano C, Scichilone N
Lung 2015 Jun;193(3):393-9. Epub 2015 Mar 11 doi: 10.1007/s00408-015-9710-1. PMID: 25757541
Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency.
Holme J, Stockley RA
Chest 2007 Sep;132(3):909-15. Epub 2007 Jun 15 doi: 10.1378/chest.07-0341. PMID: 17573491

Clinical prediction guides

Obesity-related Changes in Diffusing Capacity and Transfer Coefficient of the Lung for Carbon Monoxide and Resulting Patterns of Abnormality across Reference Equations.
Holley AB, Carbone T, Holtzclaw AW, Huprikar NA, Wagner R, Morris MJ
Ann Am Thorac Soc 2023 Jul;20(7):969-975. doi: 10.1513/AnnalsATS.202207-640OC. PMID: 36763964
Association of Gas Diffusing Capacity of the Lung for Carbon Monoxide with Cardiovascular Morbidity and Survival in a Disadvantaged Clinical Population.
Collaro AJ, Chang AB, Marchant JM, Chatfield MD, Dent A, Fong KM, McElrea MS
Lung 2022 Dec;200(6):783-792. Epub 2022 Oct 22 doi: 10.1007/s00408-022-00580-9. PMID: 36273051Free PMC Article
Older age at Fontan completion is associated with reduced lung volumes and increased lung reactance.
Laohachai K, Badal T, Thamrin C, Robinson PD, Kennedy B, Rice K, Selvadurai H, Weintraub R, Cordina R, d'Udekem Y, Ayer J
Int J Cardiol 2022 Oct 1;364:38-43. Epub 2022 Jun 14 doi: 10.1016/j.ijcard.2022.06.037. PMID: 35714716
Post-discharge chest CT findings and pulmonary function tests in severe COVID-19 patients.
Balbi M, Conti C, Imeri G, Caroli A, Surace A, Corsi A, Mercanzin E, Arrigoni A, Villa G, Di Marco F, Bonaffini PA, Sironi S
Eur J Radiol 2021 May;138:109676. Epub 2021 Mar 20 doi: 10.1016/j.ejrad.2021.109676. PMID: 33798931Free PMC Article
Early lung function abnormalities in acromegaly.
Benfante A, Ciresi A, Bellia M, Cannizzaro F, Bellia V, Giordano C, Scichilone N
Lung 2015 Jun;193(3):393-9. Epub 2015 Mar 11 doi: 10.1007/s00408-015-9710-1. PMID: 25757541

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