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Abnormal circulating collagen degradation product concentration

MedGen UID:
1786420
•Concept ID:
C5539552
•
Finding
HPO: HP:0033386

Definition

Abnormal concentration in the blood circulation of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating collagen degradation product concentration

Recent clinical studies

Etiology

Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women.
Nikolov AG, Popovski NK, Blazhev AB, Blazheva S
Folia Med (Plovdiv) 2021 Aug 31;63(4):519-526. doi: 10.3897/folmed.63.e60249. PMID: 35851173
Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis.
Hebbar M, Peyrat JP, Hornez L, Hatron PY, Hachulla E, Devulder B
Arthritis Rheum 2000 Apr;43(4):889-93. doi: 10.1002/1529-0131(200004)43:4<889::AID-ANR21>3.0.CO;2-5. PMID: 10765935
The postprandial state and risk of cardiovascular disease.
Lefèbvre PJ, Scheen AJ
Diabet Med 1998;15 Suppl 4:S63-8. doi: 10.1002/(sici)1096-9136(1998120)15:4+<s63::aid-dia737>3.3.co;2-z. PMID: 9868996
Low-dose aspirin in pregnancy.
Sibai BM, Mirro R, Chesney CM, Leffler C
Obstet Gynecol 1989 Oct;74(4):551-7. PMID: 2797631
The hemostatic mechanism after open-heart surgery. II. Frequency of abnormal platelet functions during and after extracorporeal circulation.
McKenna R, Bachmann F, Whittaker B, Gilson JR, Weinberg M
J Thorac Cardiovasc Surg 1975 Aug;70(2):298-308. PMID: 1152513

Therapy

Increased thromboxane biosynthesis in type IIa hypercholesterolemia.
Davì G, Averna M, Catalano I, Barbagallo C, Ganci A, Notarbartolo A, Ciabattoni G, Patrono C
Circulation 1992 May;85(5):1792-8. doi: 10.1161/01.cir.85.5.1792. PMID: 1572035
Low-dose aspirin in pregnancy.
Sibai BM, Mirro R, Chesney CM, Leffler C
Obstet Gynecol 1989 Oct;74(4):551-7. PMID: 2797631
Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis.
Stein SF, Harker LA
J Lab Clin Med 1982 Feb;99(2):217-30. PMID: 7061918
The hemostatic mechanism after open-heart surgery. II. Frequency of abnormal platelet functions during and after extracorporeal circulation.
McKenna R, Bachmann F, Whittaker B, Gilson JR, Weinberg M
J Thorac Cardiovasc Surg 1975 Aug;70(2):298-308. PMID: 1152513

Prognosis

Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
Int J Mol Sci 2019 Jul 2;20(13) doi: 10.3390/ijms20133264. PMID: 31269778Free PMC Article

Clinical prediction guides

Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis.
Stein SF, Harker LA
J Lab Clin Med 1982 Feb;99(2):217-30. PMID: 7061918
The hemostatic mechanism after open-heart surgery. II. Frequency of abnormal platelet functions during and after extracorporeal circulation.
McKenna R, Bachmann F, Whittaker B, Gilson JR, Weinberg M
J Thorac Cardiovasc Surg 1975 Aug;70(2):298-308. PMID: 1152513

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