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Conjunctival Diffuse Large B-Cell Lymphoma

MedGen UID:
1786523
•Concept ID:
C5446516
•
Neoplastic Process
Synonym: Primary Conjunctival Diffuse Large B-Cell Lymphoma

Definition

A diffuse large B-cell lymphoma that arises from the conjunctiva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

The treatment results in patients with lmphoma disease in the orbit.
Furdová A, Marková A, Kapitánová K, Zahorjanová P
Cesk Slov Oftalmol 2018 Spring;73(5-6):211-217. PMID: 30541302
Association of Disease Location and Treatment With Survival in Diffuse Large B-Cell Lymphoma of the Eye and Ocular Adnexal Region.
Ahmed AH, Foster CS, Shields CL
JAMA Ophthalmol 2017 Oct 1;135(10):1062-1068. doi: 10.1001/jamaophthalmol.2017.3286. PMID: 28880986Free PMC Article
A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma.
Ponzoni M, Govi S, Licata G, Mappa S, Giordano Resti A, Politi LS, Spagnuolo L, Di Cairano E, Doglioni C, Ferreri AJ
Oncologist 2013;18(7):876-84. Epub 2013 Jun 28 doi: 10.1634/theoncologist.2012-0425. PMID: 23814042Free PMC Article

Recent clinical studies

Etiology

Orbital and ocular adnexal lymphoma: a review of epidemiology and prognostic factors in Taiwan.
Hsu CR, Chen YY, Yao M, Wei YH, Hsieh YT, Liao SL
Eye (Lond) 2021 Jul;35(7):1946-1953. Epub 2020 Sep 29 doi: 10.1038/s41433-020-01198-y. PMID: 32994547Free PMC Article
Histopathological Features and Ann Arbor Stage in Periocular Lymphoma.
Zschoche M, Zimpfer A, Scheef BO, Jünemann AM, Guthoff RF, Junghanss C, Hildebrandt G, Emmert S, Erbersdobler A, Kundt G, Kakkassery V
In Vivo 2020 Jul-Aug;34(4):1965-1974. doi: 10.21873/invivo.11993. PMID: 32606168Free PMC Article
Conjunctival Lymphoma--An International Multicenter Retrospective Study.
Kirkegaard MM, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Prause JU, Ralfkiaer E, Sjö LD, Toft PB, Vemuganti GK, Thuro BA, Curtin J, Heegaard S
JAMA Ophthalmol 2016 Apr;134(4):406-14. doi: 10.1001/jamaophthalmol.2015.6122. PMID: 26891973
Diffuse large B-cell lymphoma of the ocular adnexal region: a nation-based study.
Rasmussen PK, Ralfkiaer E, Prause JU, Sjö LD, Toft PB, Siersma VD, Heegaard S
Acta Ophthalmol 2013 Mar;91(2):163-9. Epub 2012 May 2 doi: 10.1111/j.1755-3768.2011.02337.x. PMID: 22551232
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma.
Woolf DK, Ahmed M, Plowman PN
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):339-44. Epub 2012 Apr 20 doi: 10.1016/j.clon.2012.03.001. PMID: 22521959

Diagnosis

Generalized Reddish Skin Nodules.
Hamijoyo L, Yaddin DF, Wijaya I, Fianza PI, Usman HA, Hernowo BS, Ceana HY, Pangastuti M, Hartantri Y
Acta Med Indones 2023 Apr;55(2):223-225. PMID: 37524604
Diagnostic challenge: Diffuse large B-cell lymphoma masquerading as orbital cellulitis.
Wen LY, Mohamad NF, Ramli NM
Trop Doct 2023 Jan;53(1):97-99. Epub 2022 Nov 15 doi: 10.1177/00494755221137628. PMID: 36380613
Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Orbital and ocular adnexal lymphoma: a review of epidemiology and prognostic factors in Taiwan.
Hsu CR, Chen YY, Yao M, Wei YH, Hsieh YT, Liao SL
Eye (Lond) 2021 Jul;35(7):1946-1953. Epub 2020 Sep 29 doi: 10.1038/s41433-020-01198-y. PMID: 32994547Free PMC Article
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341

Therapy

Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Diffuse large B-cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: an investigation of clinical and histopathological features.
Rasmussen PK
Acta Ophthalmol 2013 Jul;91 Thesis 5:1-27. doi: 10.1111/aos.12189. PMID: 24041159
Primary lymphoma of the ocular adnexa (orbital lymphoma) and primary intraocular lymphoma.
Woolf DK, Ahmed M, Plowman PN
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):339-44. Epub 2012 Apr 20 doi: 10.1016/j.clon.2012.03.001. PMID: 22521959
Conjunctival lymphoma in a child.
Waisbourd M, Leibovitch I, Sayar D, Elhasid R
Cornea 2011 May;30(5):598-9. doi: 10.1097/ICO.0b013e3181f22cc3. PMID: 21107252
Curative radiotherapy for primary orbital lymphoma.
Bhatia S, Paulino AC, Buatti JM, Mayr NA, Wen BC
Int J Radiat Oncol Biol Phys 2002 Nov 1;54(3):818-23. doi: 10.1016/s0360-3016(02)02966-8. PMID: 12377334

Prognosis

Diagnostic challenge: Diffuse large B-cell lymphoma masquerading as orbital cellulitis.
Wen LY, Mohamad NF, Ramli NM
Trop Doct 2023 Jan;53(1):97-99. Epub 2022 Nov 15 doi: 10.1177/00494755221137628. PMID: 36380613
Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Orbital and ocular adnexal lymphoma: a review of epidemiology and prognostic factors in Taiwan.
Hsu CR, Chen YY, Yao M, Wei YH, Hsieh YT, Liao SL
Eye (Lond) 2021 Jul;35(7):1946-1953. Epub 2020 Sep 29 doi: 10.1038/s41433-020-01198-y. PMID: 32994547Free PMC Article
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Malignant lymphoma of the conjunctiva.
Kirkegaard MM, Coupland SE, Prause JU, Heegaard S
Surv Ophthalmol 2015 Sep-Oct;60(5):444-58. Epub 2015 May 21 doi: 10.1016/j.survophthal.2015.05.001. PMID: 26003619

Clinical prediction guides

Conjunctival Lymphoma.
McGrath LA, Ryan DA, Warrier SK, Coupland SE, Glasson WJ
Eye (Lond) 2023 Apr;37(5):837-848. Epub 2022 Jul 26 doi: 10.1038/s41433-022-02176-2. PMID: 35882984Free PMC Article
Ocular adnexal lymphoma: Subtype-specific clinical and genetic features.
Kirkegaard MK
Acta Ophthalmol 2022 Oct;100 Suppl 270:3-37. doi: 10.1111/aos.15248. PMID: 36196757
Conjunctival Lymphoma--An International Multicenter Retrospective Study.
Kirkegaard MM, Rasmussen PK, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Khong JJ, McKelvie PA, Mulay K, Prause JU, Ralfkiaer E, Sjö LD, Toft PB, Vemuganti GK, Thuro BA, Curtin J, Heegaard S
JAMA Ophthalmol 2016 Apr;134(4):406-14. doi: 10.1001/jamaophthalmol.2015.6122. PMID: 26891973
Diffuse large B-cell lymphoma of the ocular adnexal region: a nation-based study.
Rasmussen PK, Ralfkiaer E, Prause JU, Sjö LD, Toft PB, Siersma VD, Heegaard S
Acta Ophthalmol 2013 Mar;91(2):163-9. Epub 2012 May 2 doi: 10.1111/j.1755-3768.2011.02337.x. PMID: 22551232
Curative radiotherapy for primary orbital lymphoma.
Bhatia S, Paulino AC, Buatti JM, Mayr NA, Wen BC
Int J Radiat Oncol Biol Phys 2002 Nov 1;54(3):818-23. doi: 10.1016/s0360-3016(02)02966-8. PMID: 12377334

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