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Age-Related Thymic Involution

MedGen UID:
1786656
•Concept ID:
C5447237
•
Finding

Definition

Age-related progressive regression of the thymus gland size associated with reduction of the thymic structures and replacement by adipose tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAge-Related Thymic Involution

Professional guidelines

PubMed

Primary and secondary defects of the thymus.
Dinges SS, Amini K, Notarangelo LD, Delmonte OM
Immunol Rev 2024 Mar;322(1):178-211. Epub 2024 Jan 16 doi: 10.1111/imr.13306. PMID: 38228406Free PMC Article
Changes in thymic function with age and during the treatment of HIV infection.
Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA
Nature 1998 Dec 17;396(6712):690-5. doi: 10.1038/25374. PMID: 9872319

Recent clinical studies

Etiology

Obesity-induced thymic involution and cancer risk.
Lagou MK, Karagiannis GS
Semin Cancer Biol 2023 Aug;93:3-19. Epub 2023 Apr 22 doi: 10.1016/j.semcancer.2023.04.008. PMID: 37088128
Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice.
Singh J, Mohtashami M, Anderson G, Zúñiga-Pflücker JC
Front Immunol 2020;11:1850. Epub 2020 Aug 18 doi: 10.3389/fimmu.2020.01850. PMID: 32973763Free PMC Article
Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
Guo L, Cao JH, Wei TT, Li JH, Feng YK, Wang LP, Sun Y, Chai YR
Immunobiology 2020 Jan;225(1):151870. Epub 2019 Nov 19 doi: 10.1016/j.imbio.2019.11.005. PMID: 31822433
Sex steroid ablation: an immunoregenerative strategy for immunocompromised patients.
Velardi E, Dudakov JA, van den Brink MR
Bone Marrow Transplant 2015 Jun;50 Suppl 2(Suppl 2):S77-81. doi: 10.1038/bmt.2015.101. PMID: 26039214Free PMC Article
Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation.
Velardi E, Dudakov JA, van den Brink MR
Immunol Lett 2013 Sep-Oct;155(1-2):31-5. Epub 2013 Oct 8 doi: 10.1016/j.imlet.2013.09.016. PMID: 24120996Free PMC Article

Diagnosis

Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation.
Velardi E, Dudakov JA, van den Brink MR
Immunol Lett 2013 Sep-Oct;155(1-2):31-5. Epub 2013 Oct 8 doi: 10.1016/j.imlet.2013.09.016. PMID: 24120996Free PMC Article

Therapy

Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
Guo L, Cao JH, Wei TT, Li JH, Feng YK, Wang LP, Sun Y, Chai YR
Immunobiology 2020 Jan;225(1):151870. Epub 2019 Nov 19 doi: 10.1016/j.imbio.2019.11.005. PMID: 31822433
Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation.
Velardi E, Dudakov JA, van den Brink MR
Immunol Lett 2013 Sep-Oct;155(1-2):31-5. Epub 2013 Oct 8 doi: 10.1016/j.imlet.2013.09.016. PMID: 24120996Free PMC Article
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space.
Franceschi C, Bonafè M, Valensin S
Vaccine 2000 Feb 25;18(16):1717-20. doi: 10.1016/s0264-410x(99)00513-7. PMID: 10689155

Prognosis

Transcriptome analysis of murine thymic epithelial cells reveals age‑associated changes in microRNA expression.
Guo Z, Chi F, Song Y, Wang C, Yu R, Wei T, Gui J, Zhu X
Int J Mol Med 2013 Oct;32(4):835-42. Epub 2013 Aug 21 doi: 10.3892/ijmm.2013.1471. PMID: 23969555

Clinical prediction guides

Obesity-induced thymic involution and cancer risk.
Lagou MK, Karagiannis GS
Semin Cancer Biol 2023 Aug;93:3-19. Epub 2023 Apr 22 doi: 10.1016/j.semcancer.2023.04.008. PMID: 37088128
Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice.
Singh J, Mohtashami M, Anderson G, Zúñiga-Pflücker JC
Front Immunol 2020;11:1850. Epub 2020 Aug 18 doi: 10.3389/fimmu.2020.01850. PMID: 32973763Free PMC Article
Transcriptome analysis of murine thymic epithelial cells reveals age‑associated changes in microRNA expression.
Guo Z, Chi F, Song Y, Wang C, Yu R, Wei T, Gui J, Zhu X
Int J Mol Med 2013 Oct;32(4):835-42. Epub 2013 Aug 21 doi: 10.3892/ijmm.2013.1471. PMID: 23969555
Obesity accelerates thymic aging.
Yang H, Youm YH, Vandanmagsar B, Rood J, Kumar KG, Butler AA, Dixit VD
Blood 2009 Oct 29;114(18):3803-12. Epub 2009 Aug 31 doi: 10.1182/blood-2009-03-213595. PMID: 19721009Free PMC Article
Understanding the mechanism of the age-change of thymic function to promote T cell differentiation.
Hirokawa K, Utsuyama M, Kasai M, Kurashima C, Ishijima S, Zeng YX
Immunol Lett 1994 Jun;40(3):269-77. doi: 10.1016/0165-2478(94)00065-4. PMID: 7959895

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