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Treatment-refractory schizophrenia

MedGen UID:
1786789
Concept ID:
C3544321
Mental or Behavioral Dysfunction
Synonyms: Refractory Schizophrenia; Schizophrenia, Refractory; Schizophrenia, Treatment Resistant; Schizophrenia, Treatment-Resistant; Treatment Resistant Schizophrenia; Treatment-Resistant Schizophrenia
 
Monarch Initiative: MONDO:0005414

Definition

Schizophrenia which does not respond to commonly used treatments. [from MONDO]

Professional guidelines

PubMed

Siskind D, McCartney L, Goldschlager R, Kisely S
Br J Psychiatry 2016 Nov;209(5):385-392. Epub 2016 Jul 7 doi: 10.1192/bjp.bp.115.177261. PMID: 27388573
Van Sant SP, Buckley PF
Expert Opin Pharmacother 2011 Feb;12(3):411-34. doi: 10.1517/14656566.2011.528200. PMID: 21254948
Buckley PF, Wiggins LD, Sebastian S, Singer B
Curr Psychiatry Rep 2001 Oct;3(5):393-400. doi: 10.1007/s11920-996-0033-z. PMID: 11559476

Recent clinical studies

Etiology

Zhu MH, Liu ZJ, Hu QY, Yang JY, Jin Y, Zhu N, Huang Y, Shi DH, Liu MJ, Tan HY, Zhao L, Lv QY, Yi ZH, Wu FC, Li ZZ
Mil Med Res 2022 Oct 18;9(1):59. doi: 10.1186/s40779-022-00420-0. PMID: 36253804Free PMC Article
Vickers M, Ramineni V, Malacova E, Eriksson L, McMahon K, Moudgil V, Scott J, Siskind D
Acta Psychiatr Scand 2022 May;145(5):442-455. Epub 2022 Feb 4 doi: 10.1111/acps.13398. PMID: 35067911
Siskind D, McCartney L, Goldschlager R, Kisely S
Br J Psychiatry 2016 Nov;209(5):385-392. Epub 2016 Jul 7 doi: 10.1192/bjp.bp.115.177261. PMID: 27388573
Buckley PF, Wiggins LD, Sebastian S, Singer B
Curr Psychiatry Rep 2001 Oct;3(5):393-400. doi: 10.1007/s11920-996-0033-z. PMID: 11559476
Lindenmayer JP
Psychiatr Q 2000 Winter;71(4):373-84. doi: 10.1023/a:1004640408501. PMID: 11025914

Diagnosis

Faden J, Citrome L
Expert Opin Pharmacother 2019 Jan;20(1):11-24. Epub 2018 Nov 8 doi: 10.1080/14656566.2018.1543409. PMID: 30407873
Clark SR, Warren NS, Kim G, Jankowiak D, Schubert KO, Kisely S, Forrester T, Baune BT, Siskind DJ
Schizophr Res 2018 Feb;192:50-56. Epub 2017 Apr 6 doi: 10.1016/j.schres.2017.03.045. PMID: 28392207
Hsu WY, Lee CI, Chiu NY, Kahn DA
J Psychiatr Pract 2009 May;15(3):221-6. doi: 10.1097/01.pra.0000351883.75754.45. PMID: 19461396
Buckley P, Miller A, Olsen J, Garver D, Miller DD, Csernansky J
Schizophr Bull 2001;27(4):615-28. doi: 10.1093/oxfordjournals.schbul.a006901. PMID: 11824488
Koshino Y
Psychiatry Clin Neurosci 1999 Oct;53 Suppl:S9-13. PMID: 10560891

Therapy

Zhu MH, Liu ZJ, Hu QY, Yang JY, Jin Y, Zhu N, Huang Y, Shi DH, Liu MJ, Tan HY, Zhao L, Lv QY, Yi ZH, Wu FC, Li ZZ
Mil Med Res 2022 Oct 18;9(1):59. doi: 10.1186/s40779-022-00420-0. PMID: 36253804Free PMC Article
Vickers M, Ramineni V, Malacova E, Eriksson L, McMahon K, Moudgil V, Scott J, Siskind D
Acta Psychiatr Scand 2022 May;145(5):442-455. Epub 2022 Feb 4 doi: 10.1111/acps.13398. PMID: 35067911
Faden J, Citrome L
Expert Opin Pharmacother 2019 Jan;20(1):11-24. Epub 2018 Nov 8 doi: 10.1080/14656566.2018.1543409. PMID: 30407873
Siskind D, McCartney L, Goldschlager R, Kisely S
Br J Psychiatry 2016 Nov;209(5):385-392. Epub 2016 Jul 7 doi: 10.1192/bjp.bp.115.177261. PMID: 27388573
Van Sant SP, Buckley PF
Expert Opin Pharmacother 2011 Feb;12(3):411-34. doi: 10.1517/14656566.2011.528200. PMID: 21254948

Prognosis

Khosravi M
J Med Case Rep 2020 Sep 1;14(1):137. doi: 10.1186/s13256-020-02484-9. PMID: 32867840Free PMC Article
Siskind D, McCartney L, Goldschlager R, Kisely S
Br J Psychiatry 2016 Nov;209(5):385-392. Epub 2016 Jul 7 doi: 10.1192/bjp.bp.115.177261. PMID: 27388573
Krivoy A, Gaughran F, Weizman A, Breen G, MacCabe JH
Int Clin Psychopharmacol 2016 Jul;31(4):179-84. doi: 10.1097/YIC.0000000000000065. PMID: 25563806
Kristensen D, Hageman I, Bauer J, Jørgensen MB, Correll CU
J ECT 2013 Dec;29(4):271-6. doi: 10.1097/YCT.0b013e31828b34f6. PMID: 23859980
Heresco-Levy U, Ermilov M, Giltsinsky B, Lichtenstein M, Blander D
Schizophr Bull 1999;25(3):457-65. doi: 10.1093/oxfordjournals.schbul.a033393. PMID: 10478781

Clinical prediction guides

Dutta RR, Picton B, Brown NJ, Yang C, Lee M, Sung H, Lopez AM, Paff M
Neurosurg Focus 2023 Feb;54(2):E7. doi: 10.3171/2022.11.FOCUS22620. PMID: 36724524
Zhu MH, Liu ZJ, Hu QY, Yang JY, Jin Y, Zhu N, Huang Y, Shi DH, Liu MJ, Tan HY, Zhao L, Lv QY, Yi ZH, Wu FC, Li ZZ
Mil Med Res 2022 Oct 18;9(1):59. doi: 10.1186/s40779-022-00420-0. PMID: 36253804Free PMC Article
Vanes LD, Mouchlianitis E, Wood TC, Shergill SS
Neuroimage Clin 2018;18:186-191. Epub 2018 Jan 28 doi: 10.1016/j.nicl.2018.01.010. PMID: 29387534Free PMC Article
Siskind D, McCartney L, Goldschlager R, Kisely S
Br J Psychiatry 2016 Nov;209(5):385-392. Epub 2016 Jul 7 doi: 10.1192/bjp.bp.115.177261. PMID: 27388573
Krivoy A, Gaughran F, Weizman A, Breen G, MacCabe JH
Int Clin Psychopharmacol 2016 Jul;31(4):179-84. doi: 10.1097/YIC.0000000000000065. PMID: 25563806

Recent systematic reviews

Dutta RR, Picton B, Brown NJ, Yang C, Lee M, Sung H, Lopez AM, Paff M
Neurosurg Focus 2023 Feb;54(2):E7. doi: 10.3171/2022.11.FOCUS22620. PMID: 36724524
Todorovic A, Lal S, Dark F, De Monte V, Kisely S, Siskind D
J Ment Health 2023 Feb;32(1):321-328. Epub 2020 Oct 19 doi: 10.1080/09638237.2020.1836558. PMID: 33076721
Vickers M, Ramineni V, Malacova E, Eriksson L, McMahon K, Moudgil V, Scott J, Siskind D
Acta Psychiatr Scand 2022 May;145(5):442-455. Epub 2022 Feb 4 doi: 10.1111/acps.13398. PMID: 35067911
Siskind DJ, Lee M, Ravindran A, Zhang Q, Ma E, Motamarri B, Kisely S
Aust N Z J Psychiatry 2018 Aug;52(8):751-767. Epub 2018 May 6 doi: 10.1177/0004867418772351. PMID: 29732913
Siskind D, McCartney L, Goldschlager R, Kisely S
Br J Psychiatry 2016 Nov;209(5):385-392. Epub 2016 Jul 7 doi: 10.1192/bjp.bp.115.177261. PMID: 27388573

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