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Abnormal single motor unit action potential

MedGen UID:
1786998
•Concept ID:
C5539802
•
Finding
HPO: HP:0033767

Definition

Abnormally high or low single motor unit action potential reading (-Pk Amps). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal single motor unit action potential

Professional guidelines

PubMed

Incremental ability of needle electromyography to detect radiculopathy in patients with radiating low back pain using different diagnostic criteria.
Tong HC
Arch Phys Med Rehabil 2012 Jun;93(6):990-2. Epub 2012 Mar 29 doi: 10.1016/j.apmr.2012.01.013. PMID: 22464739

Recent clinical studies

Etiology

Dynamic Brow Restoration Using a Soft Tissue Expander in Adult Patients With Arteriovenous Malformation.
Ding W, Chen H, Lin X, Hu X
Ann Plast Surg 2020 Apr;84(4):397-401. doi: 10.1097/SAP.0000000000002140. PMID: 32040004
Impaired muscle spindle function in murine models of muscular dystrophy.
Gerwin L, Rossmanith S, Haupt C, Schultheiß J, Brinkmeier H, Bittner RE, Kröger S
J Physiol 2020 Apr;598(8):1591-1609. Epub 2020 Feb 21 doi: 10.1113/JP278563. PMID: 32003874
Neuromuscular junction disorders mimicking myopathy.
Mongiovi PC, Elsheikh B, Lawson VH, Kissel JT, Arnold WD
Muscle Nerve 2014 Nov;50(5):854-6. Epub 2014 Sep 24 doi: 10.1002/mus.24300. PMID: 24862941Free PMC Article
The subthalamic nucleus in primary dystonia: single-unit discharge characteristics.
Schrock LE, Ostrem JL, Turner RS, Shimamoto SA, Starr PA
J Neurophysiol 2009 Dec;102(6):3740-52. Epub 2009 Oct 21 doi: 10.1152/jn.00544.2009. PMID: 19846625Free PMC Article
Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness.
Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ
Crit Care Med 2003 Apr;31(4):1012-6. doi: 10.1097/01.CCM.0000053651.38421.D9. PMID: 12682465

Diagnosis

Electrophysiological evaluation of the neuromuscular junction: a brief review.
Kouyoumdjian JA, Estephan EP
Arq Neuropsiquiatr 2023 Dec;81(12):1040-1052. Epub 2023 Dec 29 doi: 10.1055/s-0043-1777749. PMID: 38157872Free PMC Article
Single fiber electromyography.
Juel VC
Handb Clin Neurol 2019;160:303-310. doi: 10.1016/B978-0-444-64032-1.00019-9. PMID: 31277856
Motor unit number estimation as a complementary test to routine electromyography in the diagnosis of amyotrophic lateral sclerosis.
Gawel M, Zalewska E, Lipowska M, Kostera-Pruszczyk A, Szmidt-Salkowska E, Kaminska A
J Electromyogr Kinesiol 2016 Feb;26:60-5. Epub 2015 Nov 11 doi: 10.1016/j.jelekin.2015.11.001. PMID: 26614440
Neuromuscular junction disorders mimicking myopathy.
Mongiovi PC, Elsheikh B, Lawson VH, Kissel JT, Arnold WD
Muscle Nerve 2014 Nov;50(5):854-6. Epub 2014 Sep 24 doi: 10.1002/mus.24300. PMID: 24862941Free PMC Article
Single-fiber electromyography.
Tanhehco JL
Phys Med Rehabil Clin N Am 2003 May;14(2):207-29. doi: 10.1016/s1047-9651(02)00123-7. PMID: 12795513

Therapy

Comparison between concentric needle EMG and macro EMG in patients with a history of polio.
Sandberg A, Hansson B, Stålberg E
Clin Neurophysiol 1999 Nov;110(11):1900-8. doi: 10.1016/s1388-2457(99)00150-9. PMID: 10576485
Conduction slowing without conduction block of compound muscle and nerve action potentials due to sodium channel block.
Yokota T, Saito Y, Miyatake T
J Neurol Sci 1994 Jul;124(2):220-4. doi: 10.1016/0022-510x(94)90330-1. PMID: 7964875
Electrical properties of motor units in Parkinsonism and a possible relationship with bradykinesia.
Milner-Brown HS, Fisher MA, Weiner WJ
J Neurol Neurosurg Psychiatry 1979 Jan;42(1):35-41. doi: 10.1136/jnnp.42.1.35. PMID: 762583Free PMC Article

Prognosis

The subthalamic nucleus in primary dystonia: single-unit discharge characteristics.
Schrock LE, Ostrem JL, Turner RS, Shimamoto SA, Starr PA
J Neurophysiol 2009 Dec;102(6):3740-52. Epub 2009 Oct 21 doi: 10.1152/jn.00544.2009. PMID: 19846625Free PMC Article
Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness.
Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ
Crit Care Med 2003 Apr;31(4):1012-6. doi: 10.1097/01.CCM.0000053651.38421.D9. PMID: 12682465
Clinical and electromyographic studies of postpoliomyelitis muscular atrophy.
Ravits J, Hallett M, Baker M, Nilsson J, Dalakas M
Muscle Nerve 1990 Aug;13(8):667-74. doi: 10.1002/mus.880130802. PMID: 2385251
Single fibre electromyography in various processes affecting the anterior horn cell.
Stålberg E, Schwartz MS, Trontelj JV
J Neurol Sci 1975 Apr;24(4):403-15. doi: 10.1016/0022-510x(75)90166-5. PMID: 1117312

Clinical prediction guides

Identification of the laterality of motor unit behavior in female patients with parkinson's disease using high-density surface electromyography.
Nishikawa Y, Watanabe K, Holobar A, Maeda N, Maruyama H, Tanaka S
Eur J Neurosci 2021 Mar;53(6):1938-1949. Epub 2021 Jan 12 doi: 10.1111/ejn.15099. PMID: 33377245
Impaired muscle spindle function in murine models of muscular dystrophy.
Gerwin L, Rossmanith S, Haupt C, Schultheiß J, Brinkmeier H, Bittner RE, Kröger S
J Physiol 2020 Apr;598(8):1591-1609. Epub 2020 Feb 21 doi: 10.1113/JP278563. PMID: 32003874
Motor unit number estimation as a complementary test to routine electromyography in the diagnosis of amyotrophic lateral sclerosis.
Gawel M, Zalewska E, Lipowska M, Kostera-Pruszczyk A, Szmidt-Salkowska E, Kaminska A
J Electromyogr Kinesiol 2016 Feb;26:60-5. Epub 2015 Nov 11 doi: 10.1016/j.jelekin.2015.11.001. PMID: 26614440
Enhancement of single motor unit inhibitory responses to transcranial magnetic stimulation in amyotrophic lateral sclerosis.
Schmied A, Attarian S
Exp Brain Res 2008 Aug;189(2):229-42. Epub 2008 May 22 doi: 10.1007/s00221-008-1420-y. PMID: 18496679
Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness.
Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ
Crit Care Med 2003 Apr;31(4):1012-6. doi: 10.1097/01.CCM.0000053651.38421.D9. PMID: 12682465

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