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Locally Advanced Pleural Malignant Mesothelioma

MedGen UID:
1787338
•Concept ID:
C5446864
•
Neoplastic Process

Definition

Pleural malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Pleural Malignant Mesothelioma

Professional guidelines

PubMed

FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma.
Kandathil A, Subramaniam RM
Semin Nucl Med 2022 Nov;52(6):650-661. Epub 2022 Jun 20 doi: 10.1053/j.semnuclmed.2022.04.011. PMID: 35738910
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148
Management of malignant pleural mesothelioma: have we made any progress?
Hiddinga BI, Surmont VF, Van Meerbeeck JP
Panminerva Med 2013 Jun;55(2):157-73. PMID: 23676957

Recent clinical studies

Etiology

Circulating SMRP and CA-125 before and after pleurectomy decortication for pleural mesothelioma.
Paajanen J, Sadek A, Richards WG, Xie Y, Mazzola E, Sidopoulos K, Kuckelman J, Gill RR, Bueno R
Thorac Cancer 2024 May;15(15):1237-1245. Epub 2024 Apr 16 doi: 10.1111/1759-7714.15264. PMID: 38627917Free PMC Article
Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease.
Collins DC, Sundar R, Constantinidou A, Dolling D, Yap TA, Popat S, O'Brien ME, Banerji U, de Bono JS, Lopez JS, Tunariu N, Minchom A
BMC Cancer 2020 Dec 9;20(1):1210. doi: 10.1186/s12885-020-07662-y. PMID: 33298007Free PMC Article
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Malignant Pleural Mesothelioma: Diagnosis, Staging, Pitfalls and Follow-up.
Odisio EG, Marom EM, Shroff GS, Wu CC, Benveniste APA, Truong MT, Benveniste MF
Semin Ultrasound CT MR 2017 Dec;38(6):559-570. Epub 2017 Aug 2 doi: 10.1053/j.sult.2017.07.006. PMID: 29179896
Malignant pleural mesothelioma.
Kindler HL
Curr Treat Options Oncol 2000 Oct;1(4):313-26. doi: 10.1007/s11864-000-0047-4. PMID: 12057157

Diagnosis

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Borea F, Franczak MA, Garcia M, Perrino M, Cordua N, Smolenski RT, Peters GJ, Dziadziuszko R, Santoro A, Zucali PA, Giovannetti E
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119165. PMID: 37298116Free PMC Article
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Conversion surgery for locally advanced malignant pleural mesothelioma.
Terada Y, Isaka M, Murakami H, Kawata T, Konno H, Kojima H, Mizuno T, Ohde Y
Gen Thorac Cardiovasc Surg 2020 Dec;68(12):1547-1550. Epub 2020 Mar 12 doi: 10.1007/s11748-020-01329-y. PMID: 32166578
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148
Management of malignant pleural mesothelioma: have we made any progress?
Hiddinga BI, Surmont VF, Van Meerbeeck JP
Panminerva Med 2013 Jun;55(2):157-73. PMID: 23676957

Therapy

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Borea F, Franczak MA, Garcia M, Perrino M, Cordua N, Smolenski RT, Peters GJ, Dziadziuszko R, Santoro A, Zucali PA, Giovannetti E
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119165. PMID: 37298116Free PMC Article
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148
Photodynamic therapy for lung cancer and malignant pleural mesothelioma.
Simone CB 2nd, Cengel KA
Semin Oncol 2014 Dec;41(6):820-30. Epub 2014 Oct 7 doi: 10.1053/j.seminoncol.2014.09.017. PMID: 25499640Free PMC Article
Local and systemic therapies for malignant pleural mesothelioma.
Gomez D, Tsao AS
Curr Treat Options Oncol 2014 Dec;15(4):683-99. doi: 10.1007/s11864-014-0314-4. PMID: 25266654

Prognosis

Immunotherapy for non-small cell lung cancer.
Kagamu H
Respir Investig 2024 Mar;62(2):307-312. Epub 2024 Feb 3 doi: 10.1016/j.resinv.2024.01.011. PMID: 38310751
Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Borea F, Franczak MA, Garcia M, Perrino M, Cordua N, Smolenski RT, Peters GJ, Dziadziuszko R, Santoro A, Zucali PA, Giovannetti E
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119165. PMID: 37298116Free PMC Article
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148

Clinical prediction guides

Immunotherapy for non-small cell lung cancer.
Kagamu H
Respir Investig 2024 Mar;62(2):307-312. Epub 2024 Feb 3 doi: 10.1016/j.resinv.2024.01.011. PMID: 38310751
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Local and systemic therapies for malignant pleural mesothelioma.
Gomez D, Tsao AS
Curr Treat Options Oncol 2014 Dec;15(4):683-99. doi: 10.1007/s11864-014-0314-4. PMID: 25266654
Management of malignant pleural mesothelioma: have we made any progress?
Hiddinga BI, Surmont VF, Van Meerbeeck JP
Panminerva Med 2013 Jun;55(2):157-73. PMID: 23676957
Malignant pleural mesothelioma.
Kindler HL
Curr Treat Options Oncol 2000 Oct;1(4):313-26. doi: 10.1007/s11864-000-0047-4. PMID: 12057157

Recent systematic reviews

Disease-Related Outcomes and Toxicities of Intensity Modulated Radiation Therapy After Lung-Sparing Pleurectomy for Malignant Pleural Mesothelioma: A Systematic Review.
Patel R, Ludmir EB, Miccio JA, Menon H, Barsky AR, Mesko SM, Kodali M, Lautenschlaeger T, Adeberg S, Simone CB 2nd, Verma V
Pract Radiat Oncol 2020 Nov-Dec;10(6):423-433. Epub 2020 Feb 20 doi: 10.1016/j.prro.2020.02.007. PMID: 32088429
Benign multicystic mesothelioma and peritoneal inclusion cysts: are they the same clinical and histopathological entities? A systematic review to find an evidence-based management.
Rapisarda AMC, Cianci A, Caruso S, Vitale SG, Valenti G, Piombino E, Cianci S
Arch Gynecol Obstet 2018 Jun;297(6):1353-1375. Epub 2018 Mar 6 doi: 10.1007/s00404-018-4728-2. PMID: 29511797
Randomized Trials of Systemic Medically-treated Malignant Mesothelioma: A Systematic Review.
Blomberg C, Nilsson J, Holgersson G, Edlund P, Bergqvist M, Adwall L, Ekman S, Brattström D, Bergström S
Anticancer Res 2015 May;35(5):2493-501. PMID: 25964522
Intensity-modulated radiotherapy after extrapleural pneumonectomy in the combined-modality treatment of malignant pleural mesothelioma.
Chi A, Liao Z, Nguyen NP, Howe C, Gomez D, Jang SY, Komaki R
J Thorac Oncol 2011 Jun;6(6):1132-41. doi: 10.1097/JTO.0b013e3182199819. PMID: 21532502

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