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Refractory Rectal Squamous Cell Carcinoma

MedGen UID:
1788072
•Concept ID:
C5447598
•
Neoplastic Process

Definition

Rectal squamous cell carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Rectal Squamous Cell Carcinoma

Recent clinical studies

Etiology

Squamous dysplasia of the rectum in a patient with ulcerative colitis treated with 6-mercaptopurine.
Greenberg R, Greenwald B, Roth JS, Ioffe O, Cross R
Dig Dis Sci 2008 Mar;53(3):760-4. Epub 2007 Aug 24 doi: 10.1007/s10620-007-9935-9. PMID: 17717741
Pruritus ani. Causes and concerns.
Daniel GL, Longo WE, Vernava AM 3rd
Dis Colon Rectum 1994 Jul;37(7):670-4. doi: 10.1007/BF02054410. PMID: 8026233
Isolated pelvic perfusion for unresectable cancer using a balloon occlusion technique.
Turk PS, Belliveau JF, Darnowski JW, Weinberg MC, Leenen L, Wanebo HJ
Arch Surg 1993 May;128(5):533-8; discussion 538-9. doi: 10.1001/archsurg.1993.01420170067009. PMID: 7683872
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
Abele R, Clavel M, Dodion P, Bruntsch U, Gundersen S, Smyth J, Renard J, van Glabbeke M, Pinedo HM
Eur J Cancer Clin Oncol 1987 Dec;23(12):1921-4. doi: 10.1016/0277-5379(87)90060-5. PMID: 2449354

Diagnosis

Pruritus ani. Causes and concerns.
Daniel GL, Longo WE, Vernava AM 3rd
Dis Colon Rectum 1994 Jul;37(7):670-4. doi: 10.1007/BF02054410. PMID: 8026233
Chemotherapy for gastrointestinal malignancy.
Van der Veer LD, Balint JA
Am J Gastroenterol 1980 Jul;74(1):40-9. PMID: 7424879

Therapy

Case Report: Utility of Ketamine, Lidocaine, and Mexiletine as Nonopioid Adjuvants in Complex Cancer-Associated Pain.
Hakim RC, Edmonds KP, Atayee RS
J Pain Palliat Care Pharmacother 2018 Mar;32(1):15-19. Epub 2018 May 8 doi: 10.1080/15360288.2018.1463345. PMID: 29737933
Squamous dysplasia of the rectum in a patient with ulcerative colitis treated with 6-mercaptopurine.
Greenberg R, Greenwald B, Roth JS, Ioffe O, Cross R
Dig Dis Sci 2008 Mar;53(3):760-4. Epub 2007 Aug 24 doi: 10.1007/s10620-007-9935-9. PMID: 17717741
Pruritus ani. Causes and concerns.
Daniel GL, Longo WE, Vernava AM 3rd
Dis Colon Rectum 1994 Jul;37(7):670-4. doi: 10.1007/BF02054410. PMID: 8026233
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
Abele R, Clavel M, Dodion P, Bruntsch U, Gundersen S, Smyth J, Renard J, van Glabbeke M, Pinedo HM
Eur J Cancer Clin Oncol 1987 Dec;23(12):1921-4. doi: 10.1016/0277-5379(87)90060-5. PMID: 2449354
Chemotherapy for gastrointestinal malignancy.
Van der Veer LD, Balint JA
Am J Gastroenterol 1980 Jul;74(1):40-9. PMID: 7424879

Prognosis

Case Report: Utility of Ketamine, Lidocaine, and Mexiletine as Nonopioid Adjuvants in Complex Cancer-Associated Pain.
Hakim RC, Edmonds KP, Atayee RS
J Pain Palliat Care Pharmacother 2018 Mar;32(1):15-19. Epub 2018 May 8 doi: 10.1080/15360288.2018.1463345. PMID: 29737933
Isolated pelvic perfusion for unresectable cancer using a balloon occlusion technique.
Turk PS, Belliveau JF, Darnowski JW, Weinberg MC, Leenen L, Wanebo HJ
Arch Surg 1993 May;128(5):533-8; discussion 538-9. doi: 10.1001/archsurg.1993.01420170067009. PMID: 7683872
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
Abele R, Clavel M, Dodion P, Bruntsch U, Gundersen S, Smyth J, Renard J, van Glabbeke M, Pinedo HM
Eur J Cancer Clin Oncol 1987 Dec;23(12):1921-4. doi: 10.1016/0277-5379(87)90060-5. PMID: 2449354
Chemotherapy for gastrointestinal malignancy.
Van der Veer LD, Balint JA
Am J Gastroenterol 1980 Jul;74(1):40-9. PMID: 7424879

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