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Abnormal circulating prealbumin concentration

MedGen UID:
1788192
•Concept ID:
C5539603
•
Finding
HPO: HP:0033450

Definition

Any deviation from normal concentration of albumin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating prealbumin concentration

Recent clinical studies

Etiology

High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus.
Choi SH, Kwak SH, Youn BS, Lim S, Park YJ, Lee H, Lee N, Cho YM, Lee HK, Kim YB, Park KS, Jang HC
J Clin Endocrinol Metab 2008 Aug;93(8):3142-8. Epub 2008 May 20 doi: 10.1210/jc.2007-1755. PMID: 18492757
The influence of nutrition on IGF-1 in tube-fed profoundly retarded adults.
Glick NR, Fischer MH, Adkins WN Jr
J Am Coll Nutr 2001 Feb;20(1):81-6. doi: 10.1080/07315724.2001.10719018. PMID: 11293472
Reduced affinity for thyroxine in two of three structural thyroxine-binding prealbumin variants associated with familial amyloidotic polyneuropathy.
Refetoff S, Dwulet FE, Benson MD
J Clin Endocrinol Metab 1986 Dec;63(6):1432-7. doi: 10.1210/jcem-63-6-1432. PMID: 3097057
Studies on plasma transthyretin (prealbumin) in familial amyloidotic polyneuropathy, Portuguese type.
Saraiva MJ, Costa PP, Goodman DS
J Lab Clin Med 1983 Oct;102(4):590-603. PMID: 6311926

Diagnosis

Abnormal serum thyroid hormones concentration with healthy functional gland: a review on the metabolic role of thyroid hormones transporter proteins.
Azad RM
Pak J Biol Sci 2011 Mar 1;14(5):313-26. doi: 10.3923/pjbs.2011.313.326. PMID: 21874823
Thyroid hormone resistance in a 35-year old man with recurrent goitre.
Lindstedt G, Lundberg PA, Sjögren B, Ernest I, Sundquist O
Scand J Clin Lab Invest 1982 Nov;42(7):585-93. PMID: 7156868
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ
Lancet 1979 Mar 24;1(8117):639-42. doi: 10.1016/s0140-6736(79)91080-8. PMID: 85873

Therapy

The influence of nutrition on IGF-1 in tube-fed profoundly retarded adults.
Glick NR, Fischer MH, Adkins WN Jr
J Am Coll Nutr 2001 Feb;20(1):81-6. doi: 10.1080/07315724.2001.10719018. PMID: 11293472
Thyroid hormone resistance in a 35-year old man with recurrent goitre.
Lindstedt G, Lundberg PA, Sjögren B, Ernest I, Sundquist O
Scand J Clin Lab Invest 1982 Nov;42(7):585-93. PMID: 7156868

Prognosis

A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia.
Schoenmakers N, Moran C, Campi I, Agostini M, Bacon O, Rajanayagam O, Schwabe J, Bradbury S, Barrett T, Geoghegan F, Druce M, Beck-Peccoz P, O'Toole A, Clark P, Bignell M, Lyons G, Halsall D, Gurnell M, Chatterjee K
J Clin Endocrinol Metab 2014 Jul;99(7):E1381-6. Epub 2014 Mar 19 doi: 10.1210/jc.2013-4077. PMID: 24646103Free PMC Article

Clinical prediction guides

A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia.
Schoenmakers N, Moran C, Campi I, Agostini M, Bacon O, Rajanayagam O, Schwabe J, Bradbury S, Barrett T, Geoghegan F, Druce M, Beck-Peccoz P, O'Toole A, Clark P, Bignell M, Lyons G, Halsall D, Gurnell M, Chatterjee K
J Clin Endocrinol Metab 2014 Jul;99(7):E1381-6. Epub 2014 Mar 19 doi: 10.1210/jc.2013-4077. PMID: 24646103Free PMC Article
Studies on plasma transthyretin (prealbumin) in familial amyloidotic polyneuropathy, Portuguese type.
Saraiva MJ, Costa PP, Goodman DS
J Lab Clin Med 1983 Oct;102(4):590-603. PMID: 6311926
Thyroid hormone resistance in a 35-year old man with recurrent goitre.
Lindstedt G, Lundberg PA, Sjögren B, Ernest I, Sundquist O
Scand J Clin Lab Invest 1982 Nov;42(7):585-93. PMID: 7156868
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ
Lancet 1979 Mar 24;1(8117):639-42. doi: 10.1016/s0140-6736(79)91080-8. PMID: 85873

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