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Steroid-sensitive nephrotic syndrome with infrequent relapses

MedGen UID:
1788286
•Concept ID:
C5539414
•
Disease or Syndrome
HPO: HP:0025648

Definition

A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of one relapse (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response, or one to three relapses in any 12-month period. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid-sensitive nephrotic syndrome with infrequent relapses

Professional guidelines

PubMed

Management strategy for idiopathic nehprotic syndrome in children.
Chiu MC
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008 Jan;33(1):1-7. PMID: 18245896
Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.
Neuhaus TJ, Fay J, Dillon MJ, Trompeter RS, Barratt TM
Arch Dis Child 1994 Dec;71(6):522-6. doi: 10.1136/adc.71.6.522. PMID: 7726612Free PMC Article
Management of nephrotic syndrome in childhood.
Melvin T, Bennett W
Drugs 1991 Jul;42(1):30-51. doi: 10.2165/00003495-199142010-00003. PMID: 1718684

Recent clinical studies

Etiology

Thyroid Hormone Level in Children with Nephrotic Syndrome.
Das K, Ali MA, Akter MM, Kabir MR, Sadika S, Momo FR, Dipu MR, Avik AD, Paul A, Noshin N
Mymensingh Med J 2023 Oct;32(4):1005-1008. PMID: 37777893
Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Assessment of hearing levels in children with nephrotic syndrome.
Erdoğan O, Yükkaldıran A, Yılmaz K
Int J Pediatr Otorhinolaryngol 2022 Sep;160:111230. Epub 2022 Jul 9 doi: 10.1016/j.ijporl.2022.111230. PMID: 35835030
Infrequent tacrolimus-induced nephrotoxicity in French patients with steroid-dependent nephrotic syndrome.
Delbet JD, Aoun B, Buob D, Degheili J, Brocheriou I, Ulinski T
Pediatr Nephrol 2019 Dec;34(12):2605-2608. Epub 2019 Sep 13 doi: 10.1007/s00467-019-04343-2. PMID: 31515630
Predictors of poor outcome in children with steroid sensitive nephrotic syndrome.
Mishra K, Kanwal SK, Sajjan SV, Bhaskar V, Rath B
Nefrologia (Engl Ed) 2018 Jul-Aug;38(4):420-424. Epub 2018 Feb 21 doi: 10.1016/j.nefro.2017.11.022. PMID: 29429831

Diagnosis

Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Assessment of hearing levels in children with nephrotic syndrome.
Erdoğan O, Yükkaldıran A, Yılmaz K
Int J Pediatr Otorhinolaryngol 2022 Sep;160:111230. Epub 2022 Jul 9 doi: 10.1016/j.ijporl.2022.111230. PMID: 35835030
Remission and Relapses in Children with Steroid Sensitive Nephrotic Syndrome in Umuahia, South East Nigeria.
Ibeneme CA, Onuh EF, Ezuruike EO
West Afr J Med 2020 Oct;37(5):548-554. PMID: 33058131
Infrequent tacrolimus-induced nephrotoxicity in French patients with steroid-dependent nephrotic syndrome.
Delbet JD, Aoun B, Buob D, Degheili J, Brocheriou I, Ulinski T
Pediatr Nephrol 2019 Dec;34(12):2605-2608. Epub 2019 Sep 13 doi: 10.1007/s00467-019-04343-2. PMID: 31515630
Predictors of poor outcome in children with steroid sensitive nephrotic syndrome.
Mishra K, Kanwal SK, Sajjan SV, Bhaskar V, Rath B
Nefrologia (Engl Ed) 2018 Jul-Aug;38(4):420-424. Epub 2018 Feb 21 doi: 10.1016/j.nefro.2017.11.022. PMID: 29429831

Therapy

Assessment of hearing levels in children with nephrotic syndrome.
Erdoğan O, Yükkaldıran A, Yılmaz K
Int J Pediatr Otorhinolaryngol 2022 Sep;160:111230. Epub 2022 Jul 9 doi: 10.1016/j.ijporl.2022.111230. PMID: 35835030
Short-Duration Prednisolone in Children with Nephrotic Syndrome Relapse: A Noninferiority Randomized Controlled Trial.
Kainth D, Hari P, Sinha A, Pandey S, Bagga A
Clin J Am Soc Nephrol 2021 Feb 8;16(2):225-232. Epub 2021 Jan 21 doi: 10.2215/CJN.06140420. PMID: 33478976Free PMC Article
Infrequent tacrolimus-induced nephrotoxicity in French patients with steroid-dependent nephrotic syndrome.
Delbet JD, Aoun B, Buob D, Degheili J, Brocheriou I, Ulinski T
Pediatr Nephrol 2019 Dec;34(12):2605-2608. Epub 2019 Sep 13 doi: 10.1007/s00467-019-04343-2. PMID: 31515630
Predictors of poor outcome in children with steroid sensitive nephrotic syndrome.
Mishra K, Kanwal SK, Sajjan SV, Bhaskar V, Rath B
Nefrologia (Engl Ed) 2018 Jul-Aug;38(4):420-424. Epub 2018 Feb 21 doi: 10.1016/j.nefro.2017.11.022. PMID: 29429831
The predictive factors for relapses in children with steroid-sensitive nephrotic syndrome.
Ali SH, Ali AM, Najim AH
Saudi J Kidney Dis Transpl 2016 Jan;27(1):67-72. doi: 10.4103/1319-2442.174075. PMID: 26787569

Prognosis

Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Remission and Relapses in Children with Steroid Sensitive Nephrotic Syndrome in Umuahia, South East Nigeria.
Ibeneme CA, Onuh EF, Ezuruike EO
West Afr J Med 2020 Oct;37(5):548-554. PMID: 33058131
Predictors of poor outcome in children with steroid sensitive nephrotic syndrome.
Mishra K, Kanwal SK, Sajjan SV, Bhaskar V, Rath B
Nefrologia (Engl Ed) 2018 Jul-Aug;38(4):420-424. Epub 2018 Feb 21 doi: 10.1016/j.nefro.2017.11.022. PMID: 29429831
Children with Steroid-resistant Nephrotic Syndrome: Long-term Outcomes of Sequential Steroid Therapy.
Zhang H, Wang Z, Dong LQ, Guo YN
Biomed Environ Sci 2016 Sep;29(9):650-655. doi: 10.3967/bes2016.087. PMID: 27806747
The predictive factors for relapses in children with steroid-sensitive nephrotic syndrome.
Ali SH, Ali AM, Najim AH
Saudi J Kidney Dis Transpl 2016 Jan;27(1):67-72. doi: 10.4103/1319-2442.174075. PMID: 26787569

Clinical prediction guides

Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.
Hadhri A, Mrabet S, Ben Aicha N, Fradi A, Azzabi A, Sahtout W, Boukadida R, Guedri Y, Zellama D, Abdessaied N, Ben Saad H, Achour A
Tunis Med 2023 Feb 11;101(2):253-258. PMID: 37682269
Factors Associated With Hypertension and Cardiovascular Parameters in Children With Infrequently Relapsing Nephrotic Syndrome.
Fathima T M, Saha A, Chopra S, Raj A, Bhatt DD, Yadav M
Indian Pediatr 2023 Jun 15;60(6):475-480. Epub 2023 Apr 20 PMID: 37211892
Predictors of poor outcome in children with steroid sensitive nephrotic syndrome.
Mishra K, Kanwal SK, Sajjan SV, Bhaskar V, Rath B
Nefrologia (Engl Ed) 2018 Jul-Aug;38(4):420-424. Epub 2018 Feb 21 doi: 10.1016/j.nefro.2017.11.022. PMID: 29429831
Children with Steroid-resistant Nephrotic Syndrome: Long-term Outcomes of Sequential Steroid Therapy.
Zhang H, Wang Z, Dong LQ, Guo YN
Biomed Environ Sci 2016 Sep;29(9):650-655. doi: 10.3967/bes2016.087. PMID: 27806747
The predictive factors for relapses in children with steroid-sensitive nephrotic syndrome.
Ali SH, Ali AM, Najim AH
Saudi J Kidney Dis Transpl 2016 Jan;27(1):67-72. doi: 10.4103/1319-2442.174075. PMID: 26787569

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