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Pulmonary cavity

MedGen UID:
1788903
•Concept ID:
C5539747
•
Finding
Synonyms: Pulmonary cavern; Pulmonary cavitation
 
HPO: HP:0033655

Definition

A gas-filled space, seen as lucency or low-attenuation area, within a nodule, mass or area of parenchymal consolidations. It has a clearly defined wall over 4 mm thick. [from HPO]

Professional guidelines

PubMed

A clinical indicator-based prognostic model predicting treatment outcomes of pulmonary tuberculosis: a prospective cohort study.
Zhan M, Xue H, Wang Y, Wu Z, Wen Q, Shi X, Wang J
BMC Infect Dis 2023 Feb 20;23(1):101. doi: 10.1186/s12879-023-08053-x. PMID: 36803117Free PMC Article
Difficulties in the differential diagnosis of large solitary pulmonary cysts.
Frick AE, Ankersmit HJ, Simonitsch-Klupp I, Hoetzenecker K
Interact Cardiovasc Thorac Surg 2022 Jun 1;34(6):1157-1159. doi: 10.1093/icvts/ivab292. PMID: 34718600Free PMC Article
Recurrent pulmonary tuberculosis after treatment success: a population-based retrospective study in China.
Ruan QL, Yang QL, Sun F, Liu W, Shen YJ, Wu J, Jiang N, Zhou JY, Shao LY, Zhang WH
Clin Microbiol Infect 2022 May;28(5):684-689. Epub 2021 Sep 30 doi: 10.1016/j.cmi.2021.09.022. PMID: 34601149

Recent clinical studies

Etiology

Risk Factors of Chronic Pulmonary Aspergillosis in Patients with Etiology Positive Pulmonary Tuberculosis.
Wang F, Zhao L, Chen L, Chen J, Chen S, Ren Y
Altern Ther Health Med 2024 Jan;30(1):83-87. PMID: 37820672
Clinical features and risk factors of pulmonary tuberculosis complicated with pulmonary aspergillosis.
Teng GL, Huang Q, Xu L, Chi JY, Wang C, Hu H
Eur Rev Med Pharmacol Sci 2022 Apr;26(8):2692-2701. doi: 10.26355/eurrev_202204_28599. PMID: 35503614
Difficulties in the differential diagnosis of large solitary pulmonary cysts.
Frick AE, Ankersmit HJ, Simonitsch-Klupp I, Hoetzenecker K
Interact Cardiovasc Thorac Surg 2022 Jun 1;34(6):1157-1159. doi: 10.1093/icvts/ivab292. PMID: 34718600Free PMC Article
Diagnostic Accuracy of CT-Guided Core Needle Biopsy for Thin-Walled Cavitary Pulmonary Lesions.
Shin KE, Park JS, Lee JW
AJR Am J Roentgenol 2021 Feb;216(2):369-375. Epub 2020 Dec 9 doi: 10.2214/AJR.20.22780. PMID: 33295816
Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid.
Liu X, Hou XF, Gao L, Deng GF, Zhang MX, Deng QY, Ye TS, Yang QT, Zhou BP, Wen ZH, Liu HY, Kornfeld H, Chen XC
Infect Dis Poverty 2018 Mar 24;7(1):22. doi: 10.1186/s40249-018-0403-x. PMID: 29580276Free PMC Article

Diagnosis

Clinical features and risk factors of pulmonary tuberculosis complicated with pulmonary aspergillosis.
Teng GL, Huang Q, Xu L, Chi JY, Wang C, Hu H
Eur Rev Med Pharmacol Sci 2022 Apr;26(8):2692-2701. doi: 10.26355/eurrev_202204_28599. PMID: 35503614
Difficulties in the differential diagnosis of large solitary pulmonary cysts.
Frick AE, Ankersmit HJ, Simonitsch-Klupp I, Hoetzenecker K
Interact Cardiovasc Thorac Surg 2022 Jun 1;34(6):1157-1159. doi: 10.1093/icvts/ivab292. PMID: 34718600Free PMC Article
Diagnostic Accuracy of CT-Guided Core Needle Biopsy for Thin-Walled Cavitary Pulmonary Lesions.
Shin KE, Park JS, Lee JW
AJR Am J Roentgenol 2021 Feb;216(2):369-375. Epub 2020 Dec 9 doi: 10.2214/AJR.20.22780. PMID: 33295816
Multidetector CT of pulmonary cavitation: filling in the holes.
Mortensen KH, Babar JL, Balan A
Clin Radiol 2015 Apr;70(4):446-56. Epub 2015 Jan 23 doi: 10.1016/j.crad.2014.12.010. PMID: 25623513
Cavitary pulmonary disease.
Gadkowski LB, Stout JE
Clin Microbiol Rev 2008 Apr;21(2):305-33, table of contents. doi: 10.1128/CMR.00060-07. PMID: 18400799Free PMC Article

Therapy

Clinical features and risk factors of pulmonary tuberculosis complicated with pulmonary aspergillosis.
Teng GL, Huang Q, Xu L, Chi JY, Wang C, Hu H
Eur Rev Med Pharmacol Sci 2022 Apr;26(8):2692-2701. doi: 10.26355/eurrev_202204_28599. PMID: 35503614
Doxycycline host-directed therapy in human pulmonary tuberculosis.
Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FS, Wang AD, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton NI, Lum J, Tay A, Chee CB, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS, Ong CW
J Clin Invest 2021 Aug 2;131(15) doi: 10.1172/JCI141895. PMID: 34128838Free PMC Article
Fulminant myocarditis and pulmonary cavity lesion induced by disseminated mucormycosis in a chronic hemodialysis patient: Report of an autopsied case.
Fujisawa Y, Hara S, Zoshima T, Maekawa N, Inoue D, Sasaki M, Gamou T, Nagata Y, Hayashi K, Takeji A, Ito K, Mizushima I, Fujii H, Kawano M
Pathol Int 2020 Aug;70(8):557-562. Epub 2020 Apr 29 doi: 10.1111/pin.12943. PMID: 32350952
Liquefaction and cavity formation in pulmonary TB: a simple method in rabbit skin to test inhibitors.
Dannenberg AM Jr
Tuberculosis (Edinb) 2009 Jul;89(4):243-7. Epub 2009 Jun 25 doi: 10.1016/j.tube.2009.05.006. PMID: 19559651
Aspergillosis.
Levitz SM
Infect Dis Clin North Am 1989 Mar;3(1):1-18. PMID: 2647828

Prognosis

A clinical indicator-based prognostic model predicting treatment outcomes of pulmonary tuberculosis: a prospective cohort study.
Zhan M, Xue H, Wang Y, Wu Z, Wen Q, Shi X, Wang J
BMC Infect Dis 2023 Feb 20;23(1):101. doi: 10.1186/s12879-023-08053-x. PMID: 36803117Free PMC Article
Clinical Profile, Risk Factors, and Therapeutic Outcome of Cavitating Fungal Pneumonia Coinfection in COVID-19 Patients: A Retrospective Analysis.
Kumar A, Mishra M, Banerjee S, Saini LK, Sharma P, Dua R, Sindhwani G
Recent Adv Antiinfect Drug Discov 2022;17(3):167-177. doi: 10.2174/2772434417666220720122042. PMID: 35864799
Predicting the risk of active pulmonary tuberculosis in people living with HIV: development and validation of a nomogram.
Chen J, Li L, Chen T, Yang X, Ru H, Li X, Yang X, Xie Q, Xu L
BMC Infect Dis 2022 Apr 19;22(1):388. doi: 10.1186/s12879-022-07368-5. PMID: 35439965Free PMC Article
Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid.
Liu X, Hou XF, Gao L, Deng GF, Zhang MX, Deng QY, Ye TS, Yang QT, Zhou BP, Wen ZH, Liu HY, Kornfeld H, Chen XC
Infect Dis Poverty 2018 Mar 24;7(1):22. doi: 10.1186/s40249-018-0403-x. PMID: 29580276Free PMC Article
Zygomycosis--a case report and overview of the disease in India.
Diwakar A, Dewan RK, Chowdhary A, Randhawa HS, Khanna G, Gaur SN
Mycoses 2007 Jul;50(4):247-54. doi: 10.1111/j.1439-0507.2007.01382.x. PMID: 17576314

Clinical prediction guides

Predicting the risk of active pulmonary tuberculosis in people living with HIV: development and validation of a nomogram.
Chen J, Li L, Chen T, Yang X, Ru H, Li X, Yang X, Xie Q, Xu L
BMC Infect Dis 2022 Apr 19;22(1):388. doi: 10.1186/s12879-022-07368-5. PMID: 35439965Free PMC Article
Large pulmonary cavity in COVID-19 cured patient case report.
Chen Y, Chen W, Zhou J, Sun C, Lei Y
Ann Palliat Med 2021 May;10(5):5786-5791. Epub 2020 Jun 9 doi: 10.21037/apm-20-452. PMID: 32527136
Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid.
Liu X, Hou XF, Gao L, Deng GF, Zhang MX, Deng QY, Ye TS, Yang QT, Zhou BP, Wen ZH, Liu HY, Kornfeld H, Chen XC
Infect Dis Poverty 2018 Mar 24;7(1):22. doi: 10.1186/s40249-018-0403-x. PMID: 29580276Free PMC Article
Liquefaction and cavity formation in pulmonary TB: a simple method in rabbit skin to test inhibitors.
Dannenberg AM Jr
Tuberculosis (Edinb) 2009 Jul;89(4):243-7. Epub 2009 Jun 25 doi: 10.1016/j.tube.2009.05.006. PMID: 19559651
Cavitary pulmonary disease.
Gadkowski LB, Stout JE
Clin Microbiol Rev 2008 Apr;21(2):305-33, table of contents. doi: 10.1128/CMR.00060-07. PMID: 18400799Free PMC Article

Recent systematic reviews

Risk factors for types of recurrent tuberculosis (reactivation versus reinfection): A global systematic review and meta-analysis.
Qiu B, Wu Z, Tao B, Li Z, Song H, Tian D, Wu J, Zhan M, Wang J
Int J Infect Dis 2022 Mar;116:14-20. Epub 2021 Dec 23 doi: 10.1016/j.ijid.2021.12.344. PMID: 34954094

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