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Lung Follicular Lymphoma

MedGen UID:
1789548
•Concept ID:
C2200133
•
Neoplastic Process
Synonym: Primary Lung Follicular Lymphoma

Definition

An exceedingly rare follicular lymphoma that arises in and is confined to the lung at the time of diagnosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Follicular Lymphoma

Professional guidelines

PubMed

Differential Diagnosis of Hematologic and Solid Tumors Using Targeted Transcriptome and Artificial Intelligence.
Zhang H, Qureshi MA, Wahid M, Charifa A, Ehsan A, Ip A, De Dios I, Ma W, Sharma I, McCloskey J, Donato M, Siegel D, Gutierrez M, Pecora A, Goy A, Albitar M
Am J Pathol 2023 Jan;193(1):51-59. Epub 2022 Oct 13 doi: 10.1016/j.ajpath.2022.09.006. PMID: 36243045
Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Imatinib in the treatment of follicular dendritic sarcoma: a case report and review of literature.
Azim HA, Elsedewy E, Azim HA Jr
Onkologie 2007 Jul;30(7):381-4. Epub 2007 Jun 27 doi: 10.1159/000103586. PMID: 17596748

Recent clinical studies

Etiology

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients.
Radtke AJ, Postovalova E, Varlamova A, Bagaev A, Sorokina M, Kudryashova O, Meerson M, Polyakova M, Galkin I, Svekolkin V, Isaev S, Wiebe D, Sharun A, Sarachakov A, Perelman G, Lozinsky Y, Yaniv Z, Lowekamp BC, Speranza E, Yao L, Pittaluga S, Shaffer AL 3rd, Jonigk D, Phelan JD, Davies-Hill T, Huang DW, Ovcharov P, Nomie K, Nuzhdina E, Kotlov N, Ataullakhanov R, Fowler N, Kelly M, Muppidi J, Davis JL, Hernandez JM, Wilson WH, Jaffe ES, Staudt LM, Roschewski M, Germain RN
Cancer Cell 2024 Mar 11;42(3):444-463.e10. Epub 2024 Feb 29 doi: 10.1016/j.ccell.2024.02.001. PMID: 38428410Free PMC Article
Incidentally Detected Malignancies in Lung Explants.
Razia D, Arjuna A, Trahan A, Hahn MF, Abdelrazek H, Omar A, Tokman S, Hashimi AS, Huang J, Smith MA, Bremner RM, Walia R
Prog Transplant 2022 Dec;32(4):332-339. Epub 2022 Sep 7 doi: 10.1177/15269248221122876. PMID: 36069063
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Primary pulmonary lymphoma.
Graham BB, Mathisen DJ, Mark EJ, Takvorian RW
Ann Thorac Surg 2005 Oct;80(4):1248-53. doi: 10.1016/j.athoracsur.2005.04.014. PMID: 16181848

Diagnosis

Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Bortezomib.
Einsele H
Recent Results Cancer Res 2014;201:325-45. doi: 10.1007/978-3-642-54490-3_20. PMID: 24756802
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351
Bortezomib.
Einsele H
Recent Results Cancer Res 2010;184:173-87. doi: 10.1007/978-3-642-01222-8_12. PMID: 20072838
Pulmonary lymphoid disorders.
Koss MN
Semin Diagn Pathol 1995 May;12(2):158-71. PMID: 7638448

Therapy

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients.
Radtke AJ, Postovalova E, Varlamova A, Bagaev A, Sorokina M, Kudryashova O, Meerson M, Polyakova M, Galkin I, Svekolkin V, Isaev S, Wiebe D, Sharun A, Sarachakov A, Perelman G, Lozinsky Y, Yaniv Z, Lowekamp BC, Speranza E, Yao L, Pittaluga S, Shaffer AL 3rd, Jonigk D, Phelan JD, Davies-Hill T, Huang DW, Ovcharov P, Nomie K, Nuzhdina E, Kotlov N, Ataullakhanov R, Fowler N, Kelly M, Muppidi J, Davis JL, Hernandez JM, Wilson WH, Jaffe ES, Staudt LM, Roschewski M, Germain RN
Cancer Cell 2024 Mar 11;42(3):444-463.e10. Epub 2024 Feb 29 doi: 10.1016/j.ccell.2024.02.001. PMID: 38428410Free PMC Article
The Oral PI3Kδ Inhibitor Linperlisib for the Treatment of Relapsed and/or Refractory Follicular Lymphoma: A Phase II, Single-Arm, Open-Label Clinical Trial.
Wang T, Sun X, Qiu L, Su H, Cao J, Li Z, Song Y, Zhang L, Li D, Wu H, Zhang W, Li J, Zhou K, Zhou H, Yang Y, Li Z, Cen H, Cai Z, Zhang Z, Fu W, Jin J, Li F, Wu W, Gu X, Zhu W, Liu L, Li Z, Yi S, Bao H, Xu Z, Qiu L
Clin Cancer Res 2023 Apr 14;29(8):1440-1449. doi: 10.1158/1078-0432.CCR-22-2939. PMID: 36735519Free PMC Article
Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial.
Bannerji R, Arnason JE, Advani RH, Brown JR, Allan JN, Ansell SM, Barnes JA, O'Brien SM, Chávez JC, Duell J, Rosenwald A, Crombie JL, Ufkin M, Li J, Zhu M, Ambati SR, Chaudhry A, Lowy I, Topp MS
Lancet Haematol 2022 May;9(5):e327-e339. Epub 2022 Apr 1 doi: 10.1016/S2352-3026(22)00072-2. PMID: 35366963Free PMC Article
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Bortezomib.
Einsele H
Recent Results Cancer Res 2014;201:325-45. doi: 10.1007/978-3-642-54490-3_20. PMID: 24756802

Prognosis

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients.
Radtke AJ, Postovalova E, Varlamova A, Bagaev A, Sorokina M, Kudryashova O, Meerson M, Polyakova M, Galkin I, Svekolkin V, Isaev S, Wiebe D, Sharun A, Sarachakov A, Perelman G, Lozinsky Y, Yaniv Z, Lowekamp BC, Speranza E, Yao L, Pittaluga S, Shaffer AL 3rd, Jonigk D, Phelan JD, Davies-Hill T, Huang DW, Ovcharov P, Nomie K, Nuzhdina E, Kotlov N, Ataullakhanov R, Fowler N, Kelly M, Muppidi J, Davis JL, Hernandez JM, Wilson WH, Jaffe ES, Staudt LM, Roschewski M, Germain RN
Cancer Cell 2024 Mar 11;42(3):444-463.e10. Epub 2024 Feb 29 doi: 10.1016/j.ccell.2024.02.001. PMID: 38428410Free PMC Article
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351
Unusual tumors of the thyroid gland.
Baloch ZW, LiVolsi VA
Endocrinol Metab Clin North Am 2008 Jun;37(2):297-310, vii. doi: 10.1016/j.ecl.2007.12.001. PMID: 18502328
Primary pulmonary lymphoma.
Graham BB, Mathisen DJ, Mark EJ, Takvorian RW
Ann Thorac Surg 2005 Oct;80(4):1248-53. doi: 10.1016/j.athoracsur.2005.04.014. PMID: 16181848

Clinical prediction guides

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients.
Radtke AJ, Postovalova E, Varlamova A, Bagaev A, Sorokina M, Kudryashova O, Meerson M, Polyakova M, Galkin I, Svekolkin V, Isaev S, Wiebe D, Sharun A, Sarachakov A, Perelman G, Lozinsky Y, Yaniv Z, Lowekamp BC, Speranza E, Yao L, Pittaluga S, Shaffer AL 3rd, Jonigk D, Phelan JD, Davies-Hill T, Huang DW, Ovcharov P, Nomie K, Nuzhdina E, Kotlov N, Ataullakhanov R, Fowler N, Kelly M, Muppidi J, Davis JL, Hernandez JM, Wilson WH, Jaffe ES, Staudt LM, Roschewski M, Germain RN
Cancer Cell 2024 Mar 11;42(3):444-463.e10. Epub 2024 Feb 29 doi: 10.1016/j.ccell.2024.02.001. PMID: 38428410Free PMC Article
Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial.
Bannerji R, Arnason JE, Advani RH, Brown JR, Allan JN, Ansell SM, Barnes JA, O'Brien SM, Chávez JC, Duell J, Rosenwald A, Crombie JL, Ufkin M, Li J, Zhu M, Ambati SR, Chaudhry A, Lowy I, Topp MS
Lancet Haematol 2022 May;9(5):e327-e339. Epub 2022 Apr 1 doi: 10.1016/S2352-3026(22)00072-2. PMID: 35366963Free PMC Article
Clinical Analysis of 50 Cases of Primary Pulmonary Lymphoma: A Retrospective Study and Literature Review.
Hu M, Gu W, Chen S, Mei J, Wang W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221075529. doi: 10.1177/15330338221075529. PMID: 35253550Free PMC Article
Histology of Interstitial Lung Disease in Common Variable Immune Deficiency.
Dhalla F, Lochlainn DJM, Chapel H, Patel SY
Front Immunol 2020;11:605187. Epub 2020 Nov 20 doi: 10.3389/fimmu.2020.605187. PMID: 33329602Free PMC Article
Primary pulmonary lymphoma.
Graham BB, Mathisen DJ, Mark EJ, Takvorian RW
Ann Thorac Surg 2005 Oct;80(4):1248-53. doi: 10.1016/j.athoracsur.2005.04.014. PMID: 16181848

Recent systematic reviews

Late-onset neutropenia after rituximab treatment: case series and comprehensive review of the literature.
Wolach O, Bairey O, Lahav M
Medicine (Baltimore) 2010 Sep;89(5):308-318. doi: 10.1097/MD.0b013e3181f2caef. PMID: 20827108
Timing of first-line cancer treatments - early versus late - a systematic review of phase III randomized trials.
Mhaskar AR, Quinn G, Vadaparampil S, Djulbegovic B, Gwede CK, Kumar A
Cancer Treat Rev 2010 Dec;36(8):621-8. Epub 2010 May 4 doi: 10.1016/j.ctrv.2010.04.001. PMID: 20444550

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