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Recurrent Low Grade Glioma

MedGen UID:
1791070
•Concept ID:
C5554629
•
Neoplastic Process

Definition

The reemergence of low grade glioma after a period of remission. [from NCI]

Professional guidelines

PubMed

Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264

Recent clinical studies

Etiology

Trametinib-based Treatment of Pediatric CNS Tumors: A Single Institutional Experience.
Paul MR, Pehlivan KC, Milburn M, Yeh-Nayre L, Elster J, Crawford JR
J Pediatr Hematol Oncol 2020 Nov;42(8):e730-e737. doi: 10.1097/MPH.0000000000001819. PMID: 32398601
Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas--a Pediatric Brain Tumor Consortium study.
Gururangan S, Fangusaro J, Poussaint TY, McLendon RE, Onar-Thomas A, Wu S, Packer RJ, Banerjee A, Gilbertson RJ, Fahey F, Vajapeyam S, Jakacki R, Gajjar A, Goldman S, Pollack IF, Friedman HS, Boyett JM, Fouladi M, Kun LE
Neuro Oncol 2014 Jan;16(2):310-7. Epub 2013 Dec 4 doi: 10.1093/neuonc/not154. PMID: 24311632Free PMC Article
Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
Reardon DA, Desjardins A, Vredenburgh JJ, Herndon JE 2nd, Coan A, Gururangan S, Peters KB, McLendon R, Sathornsumetee S, Rich JN, Lipp ES, Janney D, Friedman HS
Cancer 2012 Oct 1;118(19):4759-67. Epub 2012 Feb 27 doi: 10.1002/cncr.26541. PMID: 22371319Free PMC Article
An analysis of 38 cases of low-grade cerebral astrocytoma in adults.
Jubelirer SJ, Rubin M, Shim C
W V Med J 1993 Mar;89(3):102-5. PMID: 8475621

Diagnosis

Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S, Chandler C, Kulkarni A, Bouffet E
Pediatr Blood Cancer 2010 Sep;55(3):471-7. doi: 10.1002/pbc.22557. PMID: 20535831
An analysis of 38 cases of low-grade cerebral astrocytoma in adults.
Jubelirer SJ, Rubin M, Shim C
W V Med J 1993 Mar;89(3):102-5. PMID: 8475621

Therapy

Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial.
Mellinghoff IK, Lu M, Wen PY, Taylor JW, Maher EA, Arrillaga-Romany I, Peters KB, Ellingson BM, Rosenblum MK, Chun S, Le K, Tassinari A, Choe S, Toubouti Y, Schoenfeld S, Pandya SS, Hassan I, Steelman L, Clarke JL, Cloughesy TF
Nat Med 2023 Mar;29(3):615-622. Epub 2023 Feb 23 doi: 10.1038/s41591-022-02141-2. PMID: 36823302Free PMC Article
Trametinib-based Treatment of Pediatric CNS Tumors: A Single Institutional Experience.
Paul MR, Pehlivan KC, Milburn M, Yeh-Nayre L, Elster J, Crawford JR
J Pediatr Hematol Oncol 2020 Nov;42(8):e730-e737. doi: 10.1097/MPH.0000000000001819. PMID: 32398601
Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264
Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
Reardon DA, Desjardins A, Vredenburgh JJ, Herndon JE 2nd, Coan A, Gururangan S, Peters KB, McLendon R, Sathornsumetee S, Rich JN, Lipp ES, Janney D, Friedman HS
Cancer 2012 Oct 1;118(19):4759-67. Epub 2012 Feb 27 doi: 10.1002/cncr.26541. PMID: 22371319Free PMC Article
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S, Chandler C, Kulkarni A, Bouffet E
Pediatr Blood Cancer 2010 Sep;55(3):471-7. doi: 10.1002/pbc.22557. PMID: 20535831

Prognosis

Trametinib-based Treatment of Pediatric CNS Tumors: A Single Institutional Experience.
Paul MR, Pehlivan KC, Milburn M, Yeh-Nayre L, Elster J, Crawford JR
J Pediatr Hematol Oncol 2020 Nov;42(8):e730-e737. doi: 10.1097/MPH.0000000000001819. PMID: 32398601
Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma.
Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ
J Neurooncol 2017 Mar;132(1):171-179. Epub 2017 Jan 25 doi: 10.1007/s11060-016-2355-y. PMID: 28124178Free PMC Article
Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S, Chandler C, Kulkarni A, Bouffet E
Pediatr Blood Cancer 2010 Sep;55(3):471-7. doi: 10.1002/pbc.22557. PMID: 20535831
An analysis of 38 cases of low-grade cerebral astrocytoma in adults.
Jubelirer SJ, Rubin M, Shim C
W V Med J 1993 Mar;89(3):102-5. PMID: 8475621

Clinical prediction guides

Trametinib-based Treatment of Pediatric CNS Tumors: A Single Institutional Experience.
Paul MR, Pehlivan KC, Milburn M, Yeh-Nayre L, Elster J, Crawford JR
J Pediatr Hematol Oncol 2020 Nov;42(8):e730-e737. doi: 10.1097/MPH.0000000000001819. PMID: 32398601
Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264

Recent systematic reviews

Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264

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