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Metastatic Lung Large Cell Neuroendocrine Carcinoma

MedGen UID:
1791075
•Concept ID:
C5554634
•
Neoplastic Process

Definition

Lung large cell neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lung Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Diagnosis and treatment of neuroendocrine lung tumors.
Sánchez de Cos Escuín J
Arch Bronconeumol 2014 Sep;50(9):392-6. Epub 2014 Mar 28 doi: 10.1016/j.arbres.2014.02.004. PMID: 24685201
Current concepts in the diagnosis and management of poorly differentiated gastrointestinal neuroendocrine carcinomas.
Koumarianou A, Chatzellis E, Boutzios G, Tsavaris N, Kaltsas G
Endokrynol Pol 2013;64(1):60-72. PMID: 23450449

Recent clinical studies

Etiology

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Capecitabine and Temozolomide in Advanced Lung Neuroendocrine Neoplasms.
Al-Toubah T, Morse B, Strosberg J
Oncologist 2020 Jan;25(1):e48-e52. Epub 2019 Aug 27 doi: 10.1634/theoncologist.2019-0361. PMID: 31455747Free PMC Article
Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes.
Naidoo J, Santos-Zabala ML, Iyriboz T, Woo KM, Sima CS, Fiore JJ, Kris MG, Riely GJ, Lito P, Iqbal A, Veach S, Smith-Marrone S, Sarkaria IS, Krug LM, Rudin CM, Travis WD, Rekhtman N, Pietanza MC
Clin Lung Cancer 2016 Sep;17(5):e121-e129. Epub 2016 Jan 21 doi: 10.1016/j.cllc.2016.01.003. PMID: 26898325Free PMC Article
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Diagnosis

Large cell neuroendocrine carcinoma arising from the anterior mediastinum.
Montebello A, Zahra Bianco E, Babic D, Delicata NP, Azzopardi N
BMJ Case Rep 2021 May 25;14(5) doi: 10.1136/bcr-2020-240453. PMID: 34035017Free PMC Article
Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Diagnostic difficulties with the diagnosis of small cell carcinoma of the lung.
Marchevsky AM, Wick MR
Semin Diagn Pathol 2015 Nov;32(6):480-8. Epub 2015 Nov 10 doi: 10.1053/j.semdp.2015.11.001. PMID: 26597580
Diagnosis and treatment of neuroendocrine lung tumors.
Sánchez de Cos Escuín J
Arch Bronconeumol 2014 Sep;50(9):392-6. Epub 2014 Mar 28 doi: 10.1016/j.arbres.2014.02.004. PMID: 24685201
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Therapy

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Capecitabine and Temozolomide in Advanced Lung Neuroendocrine Neoplasms.
Al-Toubah T, Morse B, Strosberg J
Oncologist 2020 Jan;25(1):e48-e52. Epub 2019 Aug 27 doi: 10.1634/theoncologist.2019-0361. PMID: 31455747Free PMC Article
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes.
Naidoo J, Santos-Zabala ML, Iyriboz T, Woo KM, Sima CS, Fiore JJ, Kris MG, Riely GJ, Lito P, Iqbal A, Veach S, Smith-Marrone S, Sarkaria IS, Krug LM, Rudin CM, Travis WD, Rekhtman N, Pietanza MC
Clin Lung Cancer 2016 Sep;17(5):e121-e129. Epub 2016 Jan 21 doi: 10.1016/j.cllc.2016.01.003. PMID: 26898325Free PMC Article

Prognosis

Large cell neuroendocrine carcinoma arising from the anterior mediastinum.
Montebello A, Zahra Bianco E, Babic D, Delicata NP, Azzopardi N
BMJ Case Rep 2021 May 25;14(5) doi: 10.1136/bcr-2020-240453. PMID: 34035017Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Metastatic non-small cell lung carcinoma a mimic of primary breast carcinoma-case series and literature review.
Ali RH, Taraboanta C, Mohammad T, Hayes MM, Ionescu DN
Virchows Arch 2018 May;472(5):771-777. Epub 2017 Nov 5 doi: 10.1007/s00428-017-2262-4. PMID: 29105026
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Clinical prediction guides

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Breast metastasis and lung large-cell neuroendocrine carcinoma: first clinical observation.
Papa A, Rossi L, Verrico M, Di Cristofano C, Moretti V, Strudel M, Zoratto F, Minozzi M, Tomao S
Clin Respir J 2017 Sep;11(5):574-578. Epub 2015 Oct 20 doi: 10.1111/crj.12385. PMID: 26365150
Diagnostic difficulties with the diagnosis of small cell carcinoma of the lung.
Marchevsky AM, Wick MR
Semin Diagn Pathol 2015 Nov;32(6):480-8. Epub 2015 Nov 10 doi: 10.1053/j.semdp.2015.11.001. PMID: 26597580
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Recent systematic reviews

Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

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