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Bulky Mediastinal Mass

MedGen UID:
1791273
•Concept ID:
C5554832
•
Finding

Definition

When the maximum width of a mass is equal or greater than one-third of the internal transverse diameter of the thorax at the level of T5/6 on a PA CXR. Bulk at an alternate site is defined as any mass measuring 10 cm or more by any imaging study. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBulky Mediastinal Mass

Professional guidelines

PubMed

Primary mediastinal lymphoma: diagnosis and treatment options.
Martelli M, Di Rocco A, Russo E, Perrone S, Foà R
Expert Rev Hematol 2015 Apr;8(2):173-86. Epub 2014 Dec 24 doi: 10.1586/17474086.2015.994604. PMID: 25537750
Early-stage Hodgkin's disease: current approaches to treatment.
Rusthoven JJ, MacKenzie R
Can Med Assoc J 1985 Aug 1;133(3):193-8. PMID: 3893668Free PMC Article

Recent clinical studies

Etiology

The presence of a bulky mediastinal mass of 7 cm or greater in diameter confers an adverse prognosis to patients with advanced Hodgkin lymphoma in case of negative interim PET/CT.
Lopez-Alonso R, Qi S, Mashiach T, Weiler-Sagie M, Yahalom J, Dann EJ
Leuk Lymphoma 2021 Jun;62(6):1313-1324. Epub 2021 Jan 22 doi: 10.1080/10428194.2021.1872069. PMID: 33478289
Analysis of clinical characteristics and prognostic factors of primary mediastinal T-cell lymphoblastic lymphoma.
Jin X, Zhao HF, Yu Y, Zhao DD, Yang HL, Wang XF, Zhao ZG, Wang YF, Wu XX, Da WM, Zhang YZ
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2013 Apr;21(2):377-82. doi: 10.7534/j.issn.1009-2137.2013.02.024. PMID: 23628036
Superior vena cava syndrome and poor performance status at presentation affect survival in mediastinal T-lymphoblastic lymphoma--a single institute experience from India.
Tilak TV, Raina V, Kumar L, Sharma A, Sharma MC, Vishnubhatla S, Bakhshi S
Ann Hematol 2013 Jul;92(7):917-23. Epub 2013 Mar 21 doi: 10.1007/s00277-013-1727-z. PMID: 23515709
High-dose chemo/radiotherapy and autologous bone marrow or stem cell transplantation for poor-risk advanced-stage Hodgkin's disease during first partial or complete remission.
Nademanee A, Molina A, Fung H, Stein A, Parker P, Planas I, O'Donnell MR, Snyder DS, Kashyap A, Spielberger R, Bhatia R, Krishnan A, Sniecinski I, Vora N, Slovak M, Dagis A, Niland JC, Forman SJ
Biol Blood Marrow Transplant 1999;5(5):292-8. doi: 10.1016/s1083-8791(99)70004-2. PMID: 10534059
Treatment of pediatric Hodgkin disease tailored to stage, mediastinal mass, and age. An Italian (AIEOP) multicenter study on 215 patients.
Vecchi V, Pileri S, Burnelli R, Bontempi N, Comelli A, Testi AM, Carli M, Sotti G, Rosati D, Di Tullio MT
Cancer 1993 Sep 15;72(6):2049-57. doi: 10.1002/1097-0142(19930915)72:6<2049::aid-cncr2820720642>3.0.co;2-v. PMID: 7689924

Diagnosis

Mediastinal Epithelioid Angiosarcoma, New Insights into an Uncommon Diagnosis: A Case Report and Literature Review.
Navarro Sanchez JM, Oommen T, Lum C, Halford Z, Vierkoetter K
Hawaii J Health Soc Welf 2023 Sep;82(9):208-212. PMID: 37694219Free PMC Article
The primitive extratesticular seminoma: diagnosis of a rare pathology.
Saba L
Acta Biomed 2017 Apr 28;88(1):82-85. doi: 10.23750/abm.v88i1.5601. PMID: 28467339Free PMC Article
Analysis of clinical characteristics and prognostic factors of primary mediastinal T-cell lymphoblastic lymphoma.
Jin X, Zhao HF, Yu Y, Zhao DD, Yang HL, Wang XF, Zhao ZG, Wang YF, Wu XX, Da WM, Zhang YZ
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2013 Apr;21(2):377-82. doi: 10.7534/j.issn.1009-2137.2013.02.024. PMID: 23628036
Serum macrophage colony-stimulating factor (M-CSF) in patients with Hodgkin lymphoma.
Kowalska M, Tajer J, Chechlinska M, Fuksiewicz M, Kotowicz B, Kaminska J, Walewski J
Med Oncol 2012 Sep;29(3):2143-7. Epub 2011 Jun 30 doi: 10.1007/s12032-011-0010-1. PMID: 21717212
Early-stage Hodgkin's disease: current approaches to treatment.
Rusthoven JJ, MacKenzie R
Can Med Assoc J 1985 Aug 1;133(3):193-8. PMID: 3893668Free PMC Article

Therapy

The presence of a bulky mediastinal mass of 7 cm or greater in diameter confers an adverse prognosis to patients with advanced Hodgkin lymphoma in case of negative interim PET/CT.
Lopez-Alonso R, Qi S, Mashiach T, Weiler-Sagie M, Yahalom J, Dann EJ
Leuk Lymphoma 2021 Jun;62(6):1313-1324. Epub 2021 Jan 22 doi: 10.1080/10428194.2021.1872069. PMID: 33478289
Superior vena cava syndrome and poor performance status at presentation affect survival in mediastinal T-lymphoblastic lymphoma--a single institute experience from India.
Tilak TV, Raina V, Kumar L, Sharma A, Sharma MC, Vishnubhatla S, Bakhshi S
Ann Hematol 2013 Jul;92(7):917-23. Epub 2013 Mar 21 doi: 10.1007/s00277-013-1727-z. PMID: 23515709
Primary mediastinal large B-cell lymphoma (PMLBCL) in Chinese patients: clinical characteristics and prognostic factors.
Zhu YJ, Huang JJ, Xia Y, Zhao W, Jiang WQ, Lin TY, Huang HQ, Li ZM
Int J Hematol 2011 Aug;94(2):178-184. Epub 2011 Jul 29 doi: 10.1007/s12185-011-0898-4. PMID: 21800075
Risk-adapted, combined-modality therapy with VAMP/COP and response-based, involved-field radiation for unfavorable pediatric Hodgkin's disease.
Hudson MM, Krasin M, Link MP, Donaldson SS, Billups C, Merchant TE, Kun L, Billet AL, Kaste S, Tarbell NJ, Howard S, Friedmann AM, Hurwitz CA, Young JA, Marcus KC, Rai S, Cowan T, Weinstein HJ
J Clin Oncol 2004 Nov 15;22(22):4541-50. doi: 10.1200/JCO.2004.02.139. PMID: 15542805
Early-stage Hodgkin's disease: current approaches to treatment.
Rusthoven JJ, MacKenzie R
Can Med Assoc J 1985 Aug 1;133(3):193-8. PMID: 3893668Free PMC Article

Prognosis

The presence of a bulky mediastinal mass of 7 cm or greater in diameter confers an adverse prognosis to patients with advanced Hodgkin lymphoma in case of negative interim PET/CT.
Lopez-Alonso R, Qi S, Mashiach T, Weiler-Sagie M, Yahalom J, Dann EJ
Leuk Lymphoma 2021 Jun;62(6):1313-1324. Epub 2021 Jan 22 doi: 10.1080/10428194.2021.1872069. PMID: 33478289
Analysis of clinical characteristics and prognostic factors of primary mediastinal T-cell lymphoblastic lymphoma.
Jin X, Zhao HF, Yu Y, Zhao DD, Yang HL, Wang XF, Zhao ZG, Wang YF, Wu XX, Da WM, Zhang YZ
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2013 Apr;21(2):377-82. doi: 10.7534/j.issn.1009-2137.2013.02.024. PMID: 23628036
Superior vena cava syndrome and poor performance status at presentation affect survival in mediastinal T-lymphoblastic lymphoma--a single institute experience from India.
Tilak TV, Raina V, Kumar L, Sharma A, Sharma MC, Vishnubhatla S, Bakhshi S
Ann Hematol 2013 Jul;92(7):917-23. Epub 2013 Mar 21 doi: 10.1007/s00277-013-1727-z. PMID: 23515709
Serum macrophage colony-stimulating factor (M-CSF) in patients with Hodgkin lymphoma.
Kowalska M, Tajer J, Chechlinska M, Fuksiewicz M, Kotowicz B, Kaminska J, Walewski J
Med Oncol 2012 Sep;29(3):2143-7. Epub 2011 Jun 30 doi: 10.1007/s12032-011-0010-1. PMID: 21717212
Early-stage Hodgkin's disease: current approaches to treatment.
Rusthoven JJ, MacKenzie R
Can Med Assoc J 1985 Aug 1;133(3):193-8. PMID: 3893668Free PMC Article

Clinical prediction guides

The presence of a bulky mediastinal mass of 7 cm or greater in diameter confers an adverse prognosis to patients with advanced Hodgkin lymphoma in case of negative interim PET/CT.
Lopez-Alonso R, Qi S, Mashiach T, Weiler-Sagie M, Yahalom J, Dann EJ
Leuk Lymphoma 2021 Jun;62(6):1313-1324. Epub 2021 Jan 22 doi: 10.1080/10428194.2021.1872069. PMID: 33478289
Analysis of clinical characteristics and prognostic factors of primary mediastinal T-cell lymphoblastic lymphoma.
Jin X, Zhao HF, Yu Y, Zhao DD, Yang HL, Wang XF, Zhao ZG, Wang YF, Wu XX, Da WM, Zhang YZ
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2013 Apr;21(2):377-82. doi: 10.7534/j.issn.1009-2137.2013.02.024. PMID: 23628036
Superior vena cava syndrome and poor performance status at presentation affect survival in mediastinal T-lymphoblastic lymphoma--a single institute experience from India.
Tilak TV, Raina V, Kumar L, Sharma A, Sharma MC, Vishnubhatla S, Bakhshi S
Ann Hematol 2013 Jul;92(7):917-23. Epub 2013 Mar 21 doi: 10.1007/s00277-013-1727-z. PMID: 23515709
Serum macrophage colony-stimulating factor (M-CSF) in patients with Hodgkin lymphoma.
Kowalska M, Tajer J, Chechlinska M, Fuksiewicz M, Kotowicz B, Kaminska J, Walewski J
Med Oncol 2012 Sep;29(3):2143-7. Epub 2011 Jun 30 doi: 10.1007/s12032-011-0010-1. PMID: 21717212
Primary mediastinal large B-cell lymphoma (PMLBCL) in Chinese patients: clinical characteristics and prognostic factors.
Zhu YJ, Huang JJ, Xia Y, Zhao W, Jiang WQ, Lin TY, Huang HQ, Li ZM
Int J Hematol 2011 Aug;94(2):178-184. Epub 2011 Jul 29 doi: 10.1007/s12185-011-0898-4. PMID: 21800075

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