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Central Chondrosarcoma, Grade 3

MedGen UID:
1791522
•Concept ID:
C5555081
•
Neoplastic Process

Definition

A high-grade chondrosarcoma arising in the medulla of bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Chondrosarcoma, Grade 3

Professional guidelines

PubMed

Effect of Cryoablation Treatment on the Protein Expression Profile of Low-Grade Central Chondrosarcoma Identified by LC-ESI-MS/MS.
Madda R, Chen CM, Chen CF, Wang JY, Wu PK, Chen WM
J Am Soc Mass Spectrom 2021 Jun 2;32(6):1469-1489. Epub 2021 May 18 doi: 10.1021/jasms.1c00068. PMID: 34003650
Conventional Primary Central Chondrosarcoma of the Pelvis: Prognostic Factors and Outcome of Surgical Treatment in 162 Patients.
Bus MPA, Campanacci DA, Albergo JI, Leithner A, van de Sande MAJ, Gaston CL, Caff G, Mettelsiefen J, Capanna R, Tunn PU, Jeys LM, Dijkstra PDS
J Bone Joint Surg Am 2018 Feb 21;100(4):316-325. doi: 10.2106/JBJS.17.00105. PMID: 29462035
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742

Recent clinical studies

Etiology

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Clinical differences between central and peripheral chondrosarcomas.
Laitinen MK, Evans S, Stevenson J, Sumathi V, Kask G, Jeys LM, Parry MC
Bone Joint J 2021 May;103-B(5):984-990. doi: 10.1302/0301-620X.103B5.BJJ-2020-1082.R2. PMID: 33934657
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Diagnosis

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
The role of surgical margins in chondrosarcoma.
Stevenson JD, Laitinen MK, Parry MC, Sumathi V, Grimer RJ, Jeys LM
Eur J Surg Oncol 2018 Sep;44(9):1412-1418. Epub 2018 Jun 8 doi: 10.1016/j.ejso.2018.05.033. PMID: 29929901
Preoperative radiographic and histopathologic evaluation of central chondrosarcoma.
Yoshimura Y, Isobe K, Arai H, Aoki K, Kito M, Kato H
Arch Orthop Trauma Surg 2013 Sep;133(9):1225-31. Epub 2013 Jul 3 doi: 10.1007/s00402-013-1800-z. PMID: 23820853Free PMC Article
The clinical approach towards chondrosarcoma.
Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV
Oncologist 2008 Mar;13(3):320-9. doi: 10.1634/theoncologist.2007-0237. PMID: 18378543
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Therapy

A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.
Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article
Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27.
Fukumoto S, Kanbara K, Neo M
Acta Histochem 2018 Feb;120(2):142-150. Epub 2018 Feb 3 doi: 10.1016/j.acthis.2018.01.002. PMID: 29397960
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742

Prognosis

Clinical differences between central and peripheral chondrosarcomas.
Laitinen MK, Evans S, Stevenson J, Sumathi V, Kask G, Jeys LM, Parry MC
Bone Joint J 2021 May;103-B(5):984-990. doi: 10.1302/0301-620X.103B5.BJJ-2020-1082.R2. PMID: 33934657
Bone sarcoma incidence in the Netherlands.
Goedhart LM, Ho VKY, Dijkstra PDS, Schreuder HWB, Schaap GR, Ploegmakers JJW, van der Geest ICM, van de Sande MAJ, Bramer JA, Suurmeijer AJH, Jutte PC
Cancer Epidemiol 2019 Jun;60:31-38. Epub 2019 Mar 20 doi: 10.1016/j.canep.2019.03.002. PMID: 30903831
Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study.
Chen YC, Wu PK, Chen CF, Chen WM
J Chin Med Assoc 2017 Mar;80(3):178-182. Epub 2016 Nov 23 doi: 10.1016/j.jcma.2016.10.002. PMID: 27889461
The clinical approach towards chondrosarcoma.
Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV
Oncologist 2008 Mar;13(3):320-9. doi: 10.1634/theoncologist.2007-0237. PMID: 18378543
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Clinical prediction guides

The role of surgical margins in chondrosarcoma.
Stevenson JD, Laitinen MK, Parry MC, Sumathi V, Grimer RJ, Jeys LM
Eur J Surg Oncol 2018 Sep;44(9):1412-1418. Epub 2018 Jun 8 doi: 10.1016/j.ejso.2018.05.033. PMID: 29929901
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625
Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study.
Chen YC, Wu PK, Chen CF, Chen WM
J Chin Med Assoc 2017 Mar;80(3):178-182. Epub 2016 Nov 23 doi: 10.1016/j.jcma.2016.10.002. PMID: 27889461
Preoperative radiographic and histopathologic evaluation of central chondrosarcoma.
Yoshimura Y, Isobe K, Arai H, Aoki K, Kito M, Kato H
Arch Orthop Trauma Surg 2013 Sep;133(9):1225-31. Epub 2013 Jul 3 doi: 10.1007/s00402-013-1800-z. PMID: 23820853Free PMC Article

Recent systematic reviews

A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.
Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625

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