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Bone Langerhans Cell Histiocytosis

MedGen UID:: 1791592
•Concept ID:: C5555151
•: Neoplastic Process

Definition

Langerhans cell histiocytosis affecting the bone. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBone Langerhans Cell Histiocytosis

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Connective tissue disorder
        Bone Neoplasm
        Bone Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Indomethacin is an effective treatment in adults and children with bone Langerhans cell histiocytosis (LCH).

De Benedittis D, Mohamed S, Rizzo L, Santopietro M, Palumbo G, Cardarelli L, Roggini M, Giona F
Br J Haematol 2020 Dec;191(5):e109-e113. Epub 2020 Aug 30 doi: 10.1111/bjh.17067. PMID: 32862434

Isolated Langerhans Cell Histiocytosis Bone Lesion in Pediatric Patients: Systematic Review and Treatment Algorithm.

Bezdjian A, Alarfaj AA, Varma N, Daniel SJ
Otolaryngol Head Neck Surg 2015 Nov;153(5):751-7. Epub 2015 Aug 4 doi: 10.1177/0194599815598969. PMID: 26243026

See all (2)

Recent clinical studies

Etiology

Cholesteatoma Masquerading as Recurrent Langerhans Cell Histiocytosis.

Gendre A, Dréno M, Boyer J, Thomas C, Michel G
J Int Adv Otol 2023 Jan;19(1):70-73. doi: 10.5152/iao.2023.22716. PMID: 36718041 Free PMC Article

Relapses of multisystem/multifocal bone Langerhans cell histiocytosis in paediatric patients: Data analysis from the JLSG-96/02 study.

Sakamoto K, Morimoto A, Shioda Y, Imamura T, Imashuku S; Japan LCH Study Group (JLSG)
Br J Haematol 2023 Mar;200(6):769-775. Epub 2022 Dec 13 doi: 10.1111/bjh.18583. PMID: 36511451

Thoracic spine Langerhans cell histiocytosis in a child with achondroplasia.

Chan Z, Simpson L, Gallo P
BMJ Case Rep 2019 Jul 24;12(7) doi: 10.1136/bcr-2018-228801. PMID: 31345829 Free PMC Article

Langerhans cell histiocytosis of the temporal bone: A review of 29 cases at a single center.

Modest MC, Garcia JJ, Arndt CS, Carlson ML
Laryngoscope 2016 Aug;126(8):1899-904. Epub 2015 Nov 4 doi: 10.1002/lary.25773. PMID: 26535795

Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.

Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402

See all (6)

Diagnosis

Cholesteatoma Masquerading as Recurrent Langerhans Cell Histiocytosis.

Gendre A, Dréno M, Boyer J, Thomas C, Michel G
J Int Adv Otol 2023 Jan;19(1):70-73. doi: 10.5152/iao.2023.22716. PMID: 36718041 Free PMC Article

Relapses of multisystem/multifocal bone Langerhans cell histiocytosis in paediatric patients: Data analysis from the JLSG-96/02 study.

Sakamoto K, Morimoto A, Shioda Y, Imamura T, Imashuku S; Japan LCH Study Group (JLSG)
Br J Haematol 2023 Mar;200(6):769-775. Epub 2022 Dec 13 doi: 10.1111/bjh.18583. PMID: 36511451

Solitary Bone Langerhans Cell Histiocytosis Demonstrated on Multimodality Imaging in an Adult.

Zhao Y, Zhou Y, Tian R, Su M
Clin Nucl Med 2020 Jan;45(1):78-80. doi: 10.1097/RLU.0000000000002845. PMID: 31789916

Langerhans cell histiocytosis of the temporal bone: A review of 29 cases at a single center.

Modest MC, Garcia JJ, Arndt CS, Carlson ML
Laryngoscope 2016 Aug;126(8):1899-904. Epub 2015 Nov 4 doi: 10.1002/lary.25773. PMID: 26535795

Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.

Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402

See all (5)

Therapy

Relapses of multisystem/multifocal bone Langerhans cell histiocytosis in paediatric patients: Data analysis from the JLSG-96/02 study.

Sakamoto K, Morimoto A, Shioda Y, Imamura T, Imashuku S; Japan LCH Study Group (JLSG)
Br J Haematol 2023 Mar;200(6):769-775. Epub 2022 Dec 13 doi: 10.1111/bjh.18583. PMID: 36511451

Radiologic Findings of Scapular Langerhans Cell Histiocytosis Successfully Treated with CT-Guided Corticosteroid Injection.

Sahin C, Ucpinar BA, Oc Y, Kabukcuoglu F
J Coll Physicians Surg Pak 2020 Jul;30(7):754-756. doi: 10.29271/jcpsp.2020.07.754. PMID: 32811609

Thoracic spine Langerhans cell histiocytosis in a child with achondroplasia.

Chan Z, Simpson L, Gallo P
BMJ Case Rep 2019 Jul 24;12(7) doi: 10.1136/bcr-2018-228801. PMID: 31345829 Free PMC Article

Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.

Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402

See all (4)

Prognosis

Langerhans cell histiocytosis of the temporal bone: A review of 29 cases at a single center.

Modest MC, Garcia JJ, Arndt CS, Carlson ML
Laryngoscope 2016 Aug;126(8):1899-904. Epub 2015 Nov 4 doi: 10.1002/lary.25773. PMID: 26535795

Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.

Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402

Eosinophilic granuloma of the sternum in a child treated with closed biopsy.

Kontogeorgakos VA, Papachristou DJ, Malizos KN
Pediatr Int 2014 Jun;56(3):417-9. doi: 10.1111/ped.12263. PMID: 24894927

Prognostic indicators for sensorineural hearing loss in temporal bone histiocytosis.

Saliba I, Sidani K
Int J Pediatr Otorhinolaryngol 2009 Dec;73(12):1616-20. Epub 2009 Aug 9 doi: 10.1016/j.ijporl.2009.07.010. PMID: 19671478

See all (4)