U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Pineal Parenchymal Cell Neoplasm

MedGen UID:
1791984
•Concept ID:
C5555543
•
Neoplastic Process

Definition

The reemergence of pineal parenchymal cell neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Pineal Parenchymal Cell Neoplasm

Professional guidelines

PubMed

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India.
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934
Diagnosis and management of pineocytomas.
Deshmukh VR, Smith KA, Rekate HL, Coons S, Spetzler RF
Neurosurgery 2004 Aug;55(2):349-55; discussion 355-7. doi: 10.1227/01.neu.0000129479.70696.d2. PMID: 15271241

Recent clinical studies

Etiology

Second-look surgery for pineal region tumors.
Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Clinical Efficacy of Endoscopic Infratentorial Supracerebellar Approach for Pineal Region Tumors: A Retrospective Case-Control Study.
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Stereotactic Radiosurgery for Pineal Region Tumors.
Mathieu D, Iorio-Morin C
Prog Neurol Surg 2019;34:173-183. Epub 2019 May 16 doi: 10.1159/000493062. PMID: 31096261
Pinealoblastomas in children.
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Diagnosis

Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment.
Obrecht-Sturm D, Pfaff E, Mynarek M, Bison B, Rodehüser M, Becker M, Kietz S, Pfister SM, Jones DT, Sturm D, von Deimling A, Sahm F, Kortmann RD, Schwarz R, Pietsch T, Fleischhack G, Rutkowski S
J Neurooncol 2024 Jan;166(2):359-368. Epub 2024 Jan 22 doi: 10.1007/s11060-023-04547-5. PMID: 38253790Free PMC Article
Benign and Malignant Tumors of the Pineal Region.
Upadhyayula PS, Neira JA, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:153-173. doi: 10.1007/978-3-031-23705-8_6. PMID: 37452938
Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Pineoblastoma in adults.
Chang SM, Lillis-Hearne PK, Larson DA, Wara WM, Bollen AW, Prados MD
Neurosurgery 1995 Sep;37(3):383-90; discussion 390-1. doi: 10.1227/00006123-199509000-00003. PMID: 7501100
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Therapy

Clinical Efficacy of Endoscopic Infratentorial Supracerebellar Approach for Pineal Region Tumors: A Retrospective Case-Control Study.
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.
Liu APY, Gudenas B, Lin T, Orr BA, Klimo P Jr, Kumar R, Bouffet E, Gururangan S, Crawford JR, Kellie SJ, Chintagumpala M, Fisher MJ, Bowers DC, Hassall T, Indelicato DJ, Onar-Thomas A, Ellison DW, Boop FA, Merchant TE, Robinson GW, Northcott PA, Gajjar A
Acta Neuropathol 2020 Feb;139(2):259-271. Epub 2019 Dec 4 doi: 10.1007/s00401-019-02106-9. PMID: 31802236Free PMC Article
Pineal germ cell tumors.
Matsutani M
Prog Neurol Surg 2009;23:76-85. Epub 2009 Mar 23 doi: 10.1159/000210054. PMID: 19329862
Pinealoblastomas in children.
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075

Prognosis

Second-look surgery for pineal region tumors.
Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Clinical Efficacy of Endoscopic Infratentorial Supracerebellar Approach for Pineal Region Tumors: A Retrospective Case-Control Study.
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Pinealoblastomas in children.
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Clinical prediction guides

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Second-look surgery for pineal region tumors.
Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Clinical Efficacy of Endoscopic Infratentorial Supracerebellar Approach for Pineal Region Tumors: A Retrospective Case-Control Study.
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Management of mature pineal region teratomas in pediatric age group.
Tanrıkulu B, Özek MM
Childs Nerv Syst 2020 Jan;36(1):153-163. Epub 2019 May 29 doi: 10.1007/s00381-019-04204-1. PMID: 31144023
Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India.
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934

Recent systematic reviews

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Papillary tumor of the pineal region in pediatric populations: An additional case and systematic review of a rare tumor entity.
Mathkour M, Hanna J, Ibrahim N, Scullen T, Kilgore MD, Werner C, Cormier I, Spencer P, Keen JR, Bui CJ
Clin Neurol Neurosurg 2021 Feb;201:106404. Epub 2020 Dec 8 doi: 10.1016/j.clineuro.2020.106404. PMID: 33360024
Radiotherapy for papillary tumor of the pineal region: A systematic review of the literature.
Lancia A, Becherini C, Detti B, Bottero M, Baki M, Cancelli A, Ferlosio A, Scoccianti S, Sun R, Livi L, Ingrosso G
Clin Neurol Neurosurg 2020 Mar;190:105646. Epub 2019 Dec 21 doi: 10.1016/j.clineuro.2019.105646. PMID: 31896492

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...