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Ovarian Mesonephric-Like Adenocarcinoma

MedGen UID:
1792049
•Concept ID:
C5555608
•
Neoplastic Process
Synonym: Ovarian MLA

Definition

An exceedingly rare adenocarcinoma that arises from the ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Mesonephric-Like Adenocarcinoma

Professional guidelines

PubMed

Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations.
Brambs CE, Horn LC, Hiller R, Krücken I, Braun C, Christmann C, Monecke A, Höhn AK
J Cancer Res Clin Oncol 2023 Nov;149(17):15727-15736. Epub 2023 Sep 5 doi: 10.1007/s00432-023-05306-9. PMID: 37668797Free PMC Article

Recent clinical studies

Diagnosis

Ovarian Mesonephric-like Adenocarcinoma Recurring With a Rhabdomyosarcoma Component: A Case Report.
Yamamoto A, Nagai T, Sukeda A, Kajiwara M, Fukunaga M, Sasaki T, Kinoshita Y, Hayashi M, Hayashi S, Ono M, Futagami M, Nishi H
Int J Gynecol Pathol 2024 May 1;43(3):296-301. Epub 2023 Nov 13 doi: 10.1097/PGP.0000000000000991. PMID: 38085954
Ovarian Mesonephric-Like Adenocarcinoma With Recurrent Liver Metastases: A Case Report with Analysis of Therapeutic Molecular Targets.
Sugitani A, Ogawa A, Yoshida H, Kobayashi-Kato M, Kikkawa N, Tanase Y, Uno M, Ishikawa M, Kato T
Int J Surg Pathol 2024 May;32(3):578-585. Epub 2023 Jun 21 doi: 10.1177/10668969231183631. PMID: 37345348
Ovarian Mesonephric-like Adenocarcinoma With Multifocal Microscopic Involvement of the Fimbrial Surface: Potential for Misdiagnosis of Tubal Intraepithelial Metastasis as Serous Tubal Intraepithelial Carcinoma Associated With Ovarian High-grade Serous Carcinoma.
Kim H, Bae GE, Jung YY, Kim HS
In Vivo 2021 Nov-Dec;35(6):3613-3622. doi: 10.21873/invivo.12667. PMID: 34697203Free PMC Article
Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis.
Dundr P, Gregová M, Němejcová K, Bártů M, Hájková N, Hojný J, Stružinská I, Fischerová D
Diagn Pathol 2020 Jul 21;15(1):91. doi: 10.1186/s13000-020-01012-z. PMID: 32693840Free PMC Article

Prognosis

Ovarian Mesonephric-Like Adenocarcinoma With Recurrent Liver Metastases: A Case Report with Analysis of Therapeutic Molecular Targets.
Sugitani A, Ogawa A, Yoshida H, Kobayashi-Kato M, Kikkawa N, Tanase Y, Uno M, Ishikawa M, Kato T
Int J Surg Pathol 2024 May;32(3):578-585. Epub 2023 Jun 21 doi: 10.1177/10668969231183631. PMID: 37345348

Clinical prediction guides

Ovarian Mesonephric-Like Adenocarcinoma With Recurrent Liver Metastases: A Case Report with Analysis of Therapeutic Molecular Targets.
Sugitani A, Ogawa A, Yoshida H, Kobayashi-Kato M, Kikkawa N, Tanase Y, Uno M, Ishikawa M, Kato T
Int J Surg Pathol 2024 May;32(3):578-585. Epub 2023 Jun 21 doi: 10.1177/10668969231183631. PMID: 37345348

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