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High Risk Breast Carcinoma

MedGen UID:
1792118
•Concept ID:
C5555677
•
Neoplastic Process
Synonym: High-Risk Breast Carcinoma

Definition

Breast carcinoma with clinicopathologic, cytogenetic, and molecular findings that define a breast carcinoma as high risk. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Risk Breast Carcinoma

Professional guidelines

PubMed

Skin-sparing mastectomy and immediate reconstruction is an acceptable treatment option for patients with high-risk breast carcinoma.
Downes KJ, Glatt BS, Kanchwala SK, Mick R, Fraker DL, Fox KR, Solin LJ, Bucky LP, Czerniecki BJ
Cancer 2005 Mar 1;103(5):906-13. doi: 10.1002/cncr.20851. PMID: 15651068
Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment.
Gonzalez-Angulo AM, Cristofanilli M, Strom EA, Buzdar AU, Kau SW, Broglio KR, Smith TL, Hortobagyi GN
Cancer 2004 Oct 15;101(8):1760-6. doi: 10.1002/cncr.20530. PMID: 15386311
Prolonged nausea and vomiting after high dose chemotherapy and autologous peripheral stem cell transplantation in the treatment of high risk breast carcinoma.
Hecht JR, Lembo T, Chap L
Cancer 1997 May 1;79(9):1698-702. doi: 10.1002/(sici)1097-0142(19970501)79:9<1698::aid-cncr9>3.0.co;2-8. PMID: 9128984

Recent clinical studies

Etiology

Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials.
Dayan D, Lukac S, Rack B, Ebner F, Fink V, Leinert E, Veselinovic K, Schütze S, El Taie Z, Janni W, Friedl TWP
Breast Cancer Res 2023 Dec 14;25(1):153. doi: 10.1186/s13058-023-01750-0. PMID: 38098086Free PMC Article
Lobulitis in nonneoplastic breast tissue from breast cancer patients: association with phenotypes that are common in hereditary breast cancer.
Gulbahce HE, Vanderwerf S, Blair C, Sweeney C
Hum Pathol 2014 Jan;45(1):78-84. Epub 2013 Oct 21 doi: 10.1016/j.humpath.2013.08.008. PMID: 24157064
Simultaneous radiotherapy and superficial hyperthermia for high-risk breast carcinoma: a randomised comparison of treatment sequelae in heated versus non-heated sectors of the chest wall hyperthermia.
Varma S, Myerson R, Moros E, Taylor M, Straube W, Zoberi I
Int J Hyperthermia 2012;28(7):583-90. Epub 2012 Sep 4 doi: 10.3109/02656736.2012.705216. PMID: 22946861Free PMC Article
Skin-sparing mastectomy and immediate reconstruction is an acceptable treatment option for patients with high-risk breast carcinoma.
Downes KJ, Glatt BS, Kanchwala SK, Mick R, Fraker DL, Fox KR, Solin LJ, Bucky LP, Czerniecki BJ
Cancer 2005 Mar 1;103(5):906-13. doi: 10.1002/cncr.20851. PMID: 15651068
Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment.
Gonzalez-Angulo AM, Cristofanilli M, Strom EA, Buzdar AU, Kau SW, Broglio KR, Smith TL, Hortobagyi GN
Cancer 2004 Oct 15;101(8):1760-6. doi: 10.1002/cncr.20530. PMID: 15386311

Diagnosis

Incidence of brain metastases in early stage HER2 3+ breast cancer patients; is there a role for brain CT in asymptomatic patients?
Tomasevic ZI, Rakocevic Z, Tomasevic ZM, Milovanovic Z, Inic M, Kolarevic D, Lukic V, Kovac Z
J BUON 2012 Apr-Jun;17(2):249-53. PMID: 22740201
Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment.
Gonzalez-Angulo AM, Cristofanilli M, Strom EA, Buzdar AU, Kau SW, Broglio KR, Smith TL, Hortobagyi GN
Cancer 2004 Oct 15;101(8):1760-6. doi: 10.1002/cncr.20530. PMID: 15386311

Therapy

Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials.
Dayan D, Lukac S, Rack B, Ebner F, Fink V, Leinert E, Veselinovic K, Schütze S, El Taie Z, Janni W, Friedl TWP
Breast Cancer Res 2023 Dec 14;25(1):153. doi: 10.1186/s13058-023-01750-0. PMID: 38098086Free PMC Article
Simultaneous radiotherapy and superficial hyperthermia for high-risk breast carcinoma: a randomised comparison of treatment sequelae in heated versus non-heated sectors of the chest wall hyperthermia.
Varma S, Myerson R, Moros E, Taylor M, Straube W, Zoberi I
Int J Hyperthermia 2012;28(7):583-90. Epub 2012 Sep 4 doi: 10.3109/02656736.2012.705216. PMID: 22946861Free PMC Article
Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment.
Gonzalez-Angulo AM, Cristofanilli M, Strom EA, Buzdar AU, Kau SW, Broglio KR, Smith TL, Hortobagyi GN
Cancer 2004 Oct 15;101(8):1760-6. doi: 10.1002/cncr.20530. PMID: 15386311
High-dose mitoxantrone and cyclophosphamide without stem cell support in patients with high-risk and advanced breast carcinoma: a Phase II multicentric trial.
Pérez-Gracia JL, Colomer R, Esteban E, Barceló R, Benavides M, Puertas J, Arcediano A, Tornamira MV, Valentín V, Muñoz A, Cortés-Funes H, Hornedo J
Cancer 2001 Nov 15;92(10):2508-16. doi: 10.1002/1097-0142(20011115)92:10<2508::aid-cncr1601>3.0.co;2-#. PMID: 11745183
Prolonged nausea and vomiting after high dose chemotherapy and autologous peripheral stem cell transplantation in the treatment of high risk breast carcinoma.
Hecht JR, Lembo T, Chap L
Cancer 1997 May 1;79(9):1698-702. doi: 10.1002/(sici)1097-0142(19970501)79:9<1698::aid-cncr9>3.0.co;2-8. PMID: 9128984

Prognosis

Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials.
Dayan D, Lukac S, Rack B, Ebner F, Fink V, Leinert E, Veselinovic K, Schütze S, El Taie Z, Janni W, Friedl TWP
Breast Cancer Res 2023 Dec 14;25(1):153. doi: 10.1186/s13058-023-01750-0. PMID: 38098086Free PMC Article
Lobulitis in nonneoplastic breast tissue from breast cancer patients: association with phenotypes that are common in hereditary breast cancer.
Gulbahce HE, Vanderwerf S, Blair C, Sweeney C
Hum Pathol 2014 Jan;45(1):78-84. Epub 2013 Oct 21 doi: 10.1016/j.humpath.2013.08.008. PMID: 24157064
The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers.
Abdel-Fatah TM, Powe DG, Agboola J, Adamowicz-Brice M, Blamey RW, Lopez-Garcia MA, Green AR, Reis-Filho JS, Ellis IO
J Pathol 2010 Mar;220(4):419-34. doi: 10.1002/path.2663. PMID: 20044801
Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment.
Gonzalez-Angulo AM, Cristofanilli M, Strom EA, Buzdar AU, Kau SW, Broglio KR, Smith TL, Hortobagyi GN
Cancer 2004 Oct 15;101(8):1760-6. doi: 10.1002/cncr.20530. PMID: 15386311
Prognostic significance of the immunocytochemical detection of contaminating tumor cells (CTC) in apheresis products of patients with high-risk breast cancer treated with high-dose chemotherapy and stem cell transplantation.
Solano C, Badia B, Lluch A, Marugan I, Benet I, Arbona C, Prosper F, García-Conde J
Bone Marrow Transplant 2001 Feb;27(3):287-93. doi: 10.1038/sj.bmt.1702782. PMID: 11277176

Clinical prediction guides

Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials.
Dayan D, Lukac S, Rack B, Ebner F, Fink V, Leinert E, Veselinovic K, Schütze S, El Taie Z, Janni W, Friedl TWP
Breast Cancer Res 2023 Dec 14;25(1):153. doi: 10.1186/s13058-023-01750-0. PMID: 38098086Free PMC Article

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