HER2-Low Breast Carcinoma

MedGen UID:: 1792206
•Concept ID:: C5555765
•: Neoplastic Process

Synonyms:

HER2 Low Breast Adenocarcinoma; HER2 Low Breast Carcinoma; HER2-Low Breast Adenocarcinoma

Definition

Breast adenocarcinoma defined by low expression of HER2 (IHC1+ or IHC2+; FISH negative). [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHER2-Low Breast Carcinoma

Phenotypic abnormality
- Abnormality of the breast
  - Abnormal breast morphology
    - Breast neoplasm
      - Breast adenocarcinoma
        HER2-Low Breast Carcinoma
        Metastatic HER2-Low Breast Carcinoma
        Advanced HER2-Low Breast Carcinoma

Professional guidelines

PubMed

ESMO expert consensus statements (ECS) on the definition, diagnosis, and management of HER2-low breast cancer.

Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905

Biology and Treatment of HER2-Low Breast Cancer.

Nicolò E, Tarantino P, Curigliano G
Hematol Oncol Clin North Am 2023 Feb;37(1):117-132. doi: 10.1016/j.hoc.2022.08.013. PMID: 36435605

Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer.

Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548 Free PMC Article

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