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Esophageal Carcinoma Cuniculatum

MedGen UID:
1792372
•Concept ID:
C5555931
•
Neoplastic Process

Definition

An extremely rare, well-differentiated squamous cell carcinoma that arises from the esophagus. It is characterized by the presence of hyperkeratosis, acanthosis, dyskeratosis, keratin-filled cysts, koilocyte-like cells, intraepithelial neutrophils, and focal cytologic atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Carcinoma Cuniculatum

Recent clinical studies

Diagnosis

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995
Esophageal Carcinoma Cuniculatum Associated with Non-Necrotizing Granulomatous Inflammation and Lymphadenopathy: Clinicopathologic Features and Diagnostic Challenges.
Dick TM, El Hag M, Mallery JS, Amin K
Am J Case Rep 2018 Jul 5;19:790-795. doi: 10.12659/AJCR.908116. PMID: 29973579Free PMC Article
Semiquantitative histologic evaluation improves diagnosis of esophageal carcinoma cuniculatum on biopsy.
Chen D, Goldblum JR, Landau M, Rice TW, Pai RK, Xiao SY, Liu X
Mod Pathol 2013 Jun;26(6):806-15. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.224. PMID: 23348898
Esophageal carcinoma cuniculatum: report of 9 cases.
Landau M, Goldblum JR, DeRoche T, Dumot J, Downs-Kelly E, Rice TW, Xiao SY, Liu X
Am J Surg Pathol 2012 Jan;36(1):8-17. doi: 10.1097/PAS.0b013e3182348aa1. PMID: 22020041

Prognosis

Semiquantitative histologic evaluation improves diagnosis of esophageal carcinoma cuniculatum on biopsy.
Chen D, Goldblum JR, Landau M, Rice TW, Pai RK, Xiao SY, Liu X
Mod Pathol 2013 Jun;26(6):806-15. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.224. PMID: 23348898

Clinical prediction guides

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995
Semiquantitative histologic evaluation improves diagnosis of esophageal carcinoma cuniculatum on biopsy.
Chen D, Goldblum JR, Landau M, Rice TW, Pai RK, Xiao SY, Liu X
Mod Pathol 2013 Jun;26(6):806-15. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.224. PMID: 23348898

Recent systematic reviews

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995

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