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Advanced Vaginal Squamous Cell Carcinoma, Not Otherwise Specified

MedGen UID:
1793158
•Concept ID:
C5556717
•
Neoplastic Process

Definition

Vaginal squamous cell carcinoma, not otherwise specified that that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Vaginal Squamous Cell Carcinoma, Not Otherwise Specified

Professional guidelines

PubMed

Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Management of advanced primary urethral carcinomas.
Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C
BJU Int 2014 Jul;114(1):25-31. Epub 2014 May 22 doi: 10.1111/bju.12630. PMID: 24447439

Recent clinical studies

Etiology

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Cervical cancer.
Lea JS, Lin KY
Obstet Gynecol Clin North Am 2012 Jun;39(2):233-53. Epub 2012 Apr 24 doi: 10.1016/j.ogc.2012.02.008. PMID: 22640713

Diagnosis

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Erosive Lichen Planus.
Mauskar M
Obstet Gynecol Clin North Am 2017 Sep;44(3):407-420. doi: 10.1016/j.ogc.2017.04.004. PMID: 28778640
Cervical cancer in Pakistan: A review.
Batool SA, Sajjad S, Malik H
J Pak Med Assoc 2017 Jul;67(7):1074-1077. PMID: 28770890
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318

Therapy

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Cervical cancer.
Lea JS, Lin KY
Obstet Gynecol Clin North Am 2012 Jun;39(2):233-53. Epub 2012 Apr 24 doi: 10.1016/j.ogc.2012.02.008. PMID: 22640713

Prognosis

Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial.
Gupta S, Maheshwari A, Parab P, Mahantshetty U, Hawaldar R, Sastri Chopra S, Kerkar R, Engineer R, Tongaonkar H, Ghosh J, Gulia S, Kumar N, Shylasree TS, Gawade R, Kembhavi Y, Gaikar M, Menon S, Thakur M, Shrivastava S, Badwe R
J Clin Oncol 2018 Jun 1;36(16):1548-1555. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.9985. PMID: 29432076
Cervical cancer in Pakistan: A review.
Batool SA, Sajjad S, Malik H
J Pak Med Assoc 2017 Jul;67(7):1074-1077. PMID: 28770890
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Cervical cancer.
Lea JS, Lin KY
Obstet Gynecol Clin North Am 2012 Jun;39(2):233-53. Epub 2012 Apr 24 doi: 10.1016/j.ogc.2012.02.008. PMID: 22640713

Clinical prediction guides

HPV-positive clinically advanced squamous cell carcinoma of the urinary bladder (aBSCC): A comprehensive genomic profiling (CGP) study.
Ghelani GH, Zerdan MB, Jacob J, Spiess PE, Li R, Necchi A, Grivas P, Kamat A, Danziger N, Lin D, Huang R, Decker B, Sokol ES, Cheng L, Pavlick D, Ross JS, Bratslavsky G, Basnet A
Urol Oncol 2023 Dec;41(12):486.e15-486.e23. Epub 2023 Oct 9 doi: 10.1016/j.urolonc.2023.09.001. PMID: 37821306
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Diagnosis of advanced cervical cancer, missed opportunities?
Mattern J, Letendre I, Sibiude J, Pénager C, Jnifen A, Souare F, Ayel S, Nguyen T, Mandelbrot L
BMC Womens Health 2022 Mar 30;22(1):97. doi: 10.1186/s12905-022-01668-3. PMID: 35354463Free PMC Article
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Concurrent chemoradiation for locally advanced squamous cell carcinoma of the vagina: case series and literature review.
Nashiro T, Yagi C, Hirakawa M, Inamine M, Nagai Y, Sakumoto K, Tamaki W, Ogawa K, Toita T, Aoki Y
Int J Clin Oncol 2008 Aug;13(4):335-9. Epub 2008 Aug 15 doi: 10.1007/s10147-007-0758-7. PMID: 18704634

Recent systematic reviews

Definitive Radiotherapy in Invasive Vaginal Carcinoma: A Systematic Review.
Guerri S, Perrone AM, Buwenge M, Ferioli M, Macchia G, Tagliaferri L, Ferrandina G, Galuppi A, Andrulli AD, Frakulli R, Cammelli S, Arcelli A, De Iaco P, Morganti AG
Oncologist 2019 Jan;24(1):132-141. Epub 2018 Aug 23 doi: 10.1634/theoncologist.2017-0546. PMID: 30139838Free PMC Article

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