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Hybrid Salivary Gland Carcinoma

MedGen UID:
1793276
•Concept ID:
C5556835
•
Neoplastic Process

Definition

A rare carcinoma that arises from the salivary gland and consists of at least two histologically distinct types of carcinoma within the same topographic location. The carcinoma components usually are adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, and/or salivary duct carcinoma. Adenoid cystic carcinoma is commonly the predominant component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHybrid Salivary Gland Carcinoma

Professional guidelines

PubMed

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics.
Luk PP, Selinger CI, Eviston TJ, Lum T, Yu B, O'Toole SA, Clark JR, Gupta R
Pathology 2015 Dec;47(7):659-66. doi: 10.1097/PAT.0000000000000322. PMID: 26517645
Trastuzumab for the treatment of salivary duct carcinoma.
Limaye SA, Posner MR, Krane JF, Fonfria M, Lorch JH, Dillon DA, Shreenivas AV, Tishler RB, Haddad RI
Oncologist 2013;18(3):294-300. Epub 2013 Feb 21 doi: 10.1634/theoncologist.2012-0369. PMID: 23429737Free PMC Article

Recent clinical studies

Etiology

Salivary gland polymorphous adenocarcinoma: Clinicopathological features and gene alterations in 36 Japanese patients.
Fukumura M, Ishibashi K, Nakaguro M, Nagao T, Saida K, Urano M, Tanigawa M, Hirai H, Yagyuu T, Kikuchi K, Yada N, Sugita Y, Miyabe M, Hasegawa S, Goto M, Yamamoto H, Ohuchi T, Kusafuka K, Ogawa I, Suzuki H, Notohara K, Shimoda M, Tada Y, Kirita T, Takata T, Morinaga S, Maeda H, Warnakulasuriya S, Miyabe S, Nagao T
J Oral Pathol Med 2022 Sep;51(8):710-720. Epub 2022 Aug 15 doi: 10.1111/jop.13336. PMID: 35880805
Secretory carcinoma of the salivary gland, a rare entity: An international multi-institutional study.
Wiles AB, Gabrielson M, Baloch ZW, Faquin WC, Jo VY, Callegari F, Kholova I, Song S, Centeno BA, Ali SZ, Tommola S, Fadda G, Petrone G, Wang H, Rossi ED, Pantanowitz L, Maleki Z
Cancer Cytopathol 2022 Sep;130(9):684-694. Epub 2022 Apr 6 doi: 10.1002/cncy.22574. PMID: 35385604Free PMC Article
ALK alterations in salivary gland carcinomas.
Majewska H, Gorczyński A, Czapiewski P, Menon R, Mueller J, Lakis S, Heuckmann JM, Laco J, Gupta R, Andreasen S, Stodulski D, Iliszko M, Dziadziuszko R, Jassem J, Heukamp LC, Biernat W
Virchows Arch 2021 May;478(5):933-941. Epub 2020 Nov 25 doi: 10.1007/s00428-020-02971-w. PMID: 33237469Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Histologic grading and prognostic biomarkers in salivary gland carcinomas.
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736

Diagnosis

Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Identifying patients with NTRK fusion cancer.
Solomon JP, Benayed R, Hechtman JF, Ladanyi M
Ann Oncol 2019 Nov;30 Suppl 8:viii16-viii22. Epub 2019 Dec 24 doi: 10.1093/annonc/mdz384. PMID: 32223934
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269

Therapy

Retrospective Study of Cisplatin/Carboplatin, 5-Fluorouracil Plus Cetuximab (EXTREME) for Advanced-stage Salivary Gland Cancer.
Nakano T, Yasumatsu R, Hashimoto K, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
In Vivo 2022 Mar-Apr;36(2):979-984. doi: 10.21873/invivo.12790. PMID: 35241559Free PMC Article
C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways.
Qiu L, Liu Z, Wu C, Chen W, Chen Y, Zhang B, Li J, Liu H, Huang N, Jiang Z, Wu Y, Li L
Biochem Biophys Res Commun 2020 May 14;525(4):997-1003. Epub 2020 Mar 13 doi: 10.1016/j.bbrc.2020.02.164. PMID: 32178876
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Salivary duct carcinoma of the parotid gland: is adjuvant HER-2-targeted therapy required?
Lee JS, Kwon OJ, Park JJ, Seo JH
J Oral Maxillofac Surg 2014 May;72(5):1023-31. Epub 2013 Nov 22 doi: 10.1016/j.joms.2013.11.014. PMID: 24480767
Salivary duct carcinoma: a clinical and histologic review with implications for trastuzumab therapy.
Nabili V, Tan JW, Bhuta S, Sercarz JA, Head CS
Head Neck 2007 Oct;29(10):907-12. doi: 10.1002/hed.20614. PMID: 17563907

Prognosis

Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209Free PMC Article
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Salivary gland lesions: recent advances and evolving concepts.
Gupta R, Balasubramanian D, Clark JR
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jun;119(6):661-74. Epub 2015 Mar 2 doi: 10.1016/j.oooo.2015.02.481. PMID: 25840511

Clinical prediction guides

Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209Free PMC Article
Secretory Carcinoma Of Salivary Gland: A Clincopathological Analysis.
Akhtar N, Atiq A, Loya A, Hassan U, Hussain M, Abu-Bakar M, Mushtaq S
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(4):481-486. PMID: 33225648
Characterization of novel genetic alterations in salivary gland secretory carcinoma.
Na K, Hernandez-Prera JC, Lim JY, Woo HY, Yoon SO
Mod Pathol 2020 Apr;33(4):541-550. Epub 2019 Dec 10 doi: 10.1038/s41379-019-0427-1. PMID: 31822803Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
Head Neck Pathol 2021 Mar;15(1):236-243. Epub 2020 Feb 19 doi: 10.1007/s12105-020-01141-3. PMID: 32077054Free PMC Article
Mammary analogue secretory carcinoma: An Indian experience of a novel entity.
Nisar Z, Pol JN, Jagdale RV, Phadke MD, Kadkol GA
Indian J Pathol Microbiol 2020 Feb;63(Supplement):S134-S140. doi: 10.4103/IJPM.IJPM_757_18. PMID: 32108646
t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389

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