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Attention deficit-hyperactivity disorder 8(ADHD8)

MedGen UID:
1808030
Concept ID:
C5677018
Mental or Behavioral Dysfunction
Synonym: ADHD8
 
Gene (location): CDH2 (18q12.1)
 
Monarch Initiative: MONDO:0859261
OMIM®: 619957

Definition

Attention deficit-hyperactivity disorder-8 (ADHD8) is a severe early-childhood neuropsychiatric disorder characterized by a persistent pattern of hyperactive behavior and impulsivity (Halperin et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of attention deficit-hyperactivity disorder, see 143465. [from OMIM]

Clinical features

From HPO
Attention deficit hyperactivity disorder
MedGen UID:
220387
Concept ID:
C1263846
Mental or Behavioral Dysfunction
Attention-deficit/hyperactivity disorder (ADHD) is a behavioral disorder that typically begins in childhood and is characterized by a short attention span (inattention), an inability to be calm and stay still (hyperactivity), and poor impulse control (impulsivity). Some people with ADHD have problems with only inattention or with hyperactivity and impulsivity, but most have problems related to all three features.\n\nIn people with ADHD, the characteristic behaviors are frequent and severe enough to interfere with the activities of daily living such as school, work, and relationships with others. Because of an inability to stay focused on tasks, people with inattention may be easily distracted, forgetful, avoid tasks that require sustained attention, have difficulty organizing tasks, or frequently lose items.\n\nIn most affected individuals, ADHD continues throughout life, but in about one-third of individuals, signs and symptoms of ADHD go away by adulthood.\n\nHyperactivity is usually shown by frequent movement. Individuals with this feature often fidget or tap their foot when seated, leave their seat when it is inappropriate to do so (such as in the classroom), or talk a lot and interrupt others.\n\nImpulsivity can result in hasty actions without thought for the consequences. Individuals with poor impulse control may have difficulty waiting for their turn, deferring to others, or considering their actions before acting.\n\nMore than two-thirds of all individuals with ADHD have additional conditions, including insomnia, mood or anxiety disorders, learning disorders, or substance use disorders. Affected individuals may also have autism spectrum disorder, which is characterized by impaired communication and social interaction, or Tourette syndrome, which is a disorder characterized by repetitive and involuntary movements or noises called tics.
Mild global developmental delay
MedGen UID:
861405
Concept ID:
C4012968
Finding
A mild delay in the achievement of motor or mental milestones in the domains of development of a child.

Professional guidelines

PubMed

Cichoń L, Janas-Kozik M, Siwiec A, Rybakowski JK
Psychiatr Pol 2020 Mar 29;54(1):35-50. doi: 10.12740/PP/OnlineFirst/92740. PMID: 32447355
Howes OD, Rogdaki M, Findon JL, Wichers RH, Charman T, King BH, Loth E, McAlonan GM, McCracken JT, Parr JR, Povey C, Santosh P, Wallace S, Simonoff E, Murphy DG
J Psychopharmacol 2018 Jan;32(1):3-29. Epub 2017 Dec 14 doi: 10.1177/0269881117741766. PMID: 29237331Free PMC Article
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R; Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines
Endocr Pract 2016 Jul;22 Suppl 3:1-203. Epub 2016 May 24 doi: 10.4158/EP161365.GL. PMID: 27219496

Recent clinical studies

Etiology

Du R, Zhou Y, You C, Liu K, King DA, Liang ZS, Ranson JM, Llewellyn DJ, Huang J, Zhang Z
Int J Stroke 2023 Mar;18(3):346-353. Epub 2022 Jul 6 doi: 10.1177/17474930221108272. PMID: 35670701
S Alamri A
Pak J Biol Sci 2021 Jan;24(8):913-919. doi: 10.3923/pjbs.2021.913.919. PMID: 34486359
Del-Ponte B, Anselmi L, Assunção MCF, Tovo-Rodrigues L, Munhoz TN, Matijasevich A, Rohde LA, Santos IS
J Affect Disord 2019 Jan 15;243:290-296. Epub 2018 Sep 17 doi: 10.1016/j.jad.2018.09.051. PMID: 30257225Free PMC Article
Banerjee TD, Middleton F, Faraone SV
Acta Paediatr 2007 Sep;96(9):1269-74. doi: 10.1111/j.1651-2227.2007.00430.x. PMID: 17718779
Biederman J, Faraone SV
Lancet 2005 Jul 16-22;366(9481):237-48. doi: 10.1016/S0140-6736(05)66915-2. PMID: 16023516

Diagnosis

Anbarasan D, Kitchin M, Adler LA
Curr Psychiatry Rep 2020 Oct 23;22(12):72. doi: 10.1007/s11920-020-01194-9. PMID: 33095375
Salvi V, Migliarese G, Venturi V, Rossi F, Torriero S, Viganò V, Cerveri G, Mencacci C
Riv Psichiatr 2019 Mar-Apr;54(2):84-89. doi: 10.1708/3142.31249. PMID: 30985833
Thomas R, Sanders S, Doust J, Beller E, Glasziou P
Pediatrics 2015 Apr;135(4):e994-1001. Epub 2015 Mar 2 doi: 10.1542/peds.2014-3482. PMID: 25733754
Banerjee TD, Middleton F, Faraone SV
Acta Paediatr 2007 Sep;96(9):1269-74. doi: 10.1111/j.1651-2227.2007.00430.x. PMID: 17718779
Biederman J, Faraone SV
Lancet 2005 Jul 16-22;366(9481):237-48. doi: 10.1016/S0140-6736(05)66915-2. PMID: 16023516

Therapy

Johnstone JM, Hatsu I, Tost G, Srikanth P, Eiterman LP, Bruton AM, Ast HK, Robinette LM, Stern MM, Millington EG, Gracious BL, Hughes AJ, Leung BMY, Arnold LE
J Am Acad Child Adolesc Psychiatry 2022 May;61(5):647-661. Epub 2021 Jul 22 doi: 10.1016/j.jaac.2021.07.005. PMID: 34303786Free PMC Article
Rubia K, Westwood S, Aggensteiner PM, Brandeis D
Cells 2021 Aug 21;10(8) doi: 10.3390/cells10082156. PMID: 34440925Free PMC Article
Del-Ponte B, Anselmi L, Assunção MCF, Tovo-Rodrigues L, Munhoz TN, Matijasevich A, Rohde LA, Santos IS
J Affect Disord 2019 Jan 15;243:290-296. Epub 2018 Sep 17 doi: 10.1016/j.jad.2018.09.051. PMID: 30257225Free PMC Article
Thomas R, Sanders S, Doust J, Beller E, Glasziou P
Pediatrics 2015 Apr;135(4):e994-1001. Epub 2015 Mar 2 doi: 10.1542/peds.2014-3482. PMID: 25733754
Banerjee TD, Middleton F, Faraone SV
Acta Paediatr 2007 Sep;96(9):1269-74. doi: 10.1111/j.1651-2227.2007.00430.x. PMID: 17718779

Prognosis

Li L, Zhu N, Zhang L, Kuja-Halkola R, D'Onofrio BM, Brikell I, Lichtenstein P, Cortese S, Larsson H, Chang Z
JAMA 2024 Mar 12;331(10):850-860. doi: 10.1001/jama.2024.0851. PMID: 38470385Free PMC Article
Salvi V, Migliarese G, Venturi V, Rossi F, Torriero S, Viganò V, Cerveri G, Mencacci C
Riv Psichiatr 2019 Mar-Apr;54(2):84-89. doi: 10.1708/3142.31249. PMID: 30985833
Cohen SCL, Harvey DJ, Shields RH, Shields GS, Rashedi RN, Tancredi DJ, Angkustsiri K, Hansen RL, Schweitzer JB
J Dev Behav Pediatr 2018 Apr;39(3):200-209. doi: 10.1097/DBP.0000000000000552. PMID: 29538185Free PMC Article
Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P
Eur Neuropsychopharmacol 2017 Aug;27(8):795-808. Epub 2017 May 30 doi: 10.1016/j.euroneuro.2017.05.005. PMID: 28576350
Weinstein A, Lejoyeux M
Am J Drug Alcohol Abuse 2010 Sep;36(5):277-83. doi: 10.3109/00952990.2010.491880. PMID: 20545603

Clinical prediction guides

Du R, Zhou Y, You C, Liu K, King DA, Liang ZS, Ranson JM, Llewellyn DJ, Huang J, Zhang Z
Int J Stroke 2023 Mar;18(3):346-353. Epub 2022 Jul 6 doi: 10.1177/17474930221108272. PMID: 35670701
Kazda L, McGeechan K, Bell K, Thomas R, Barratt A
JAMA Netw Open 2022 Oct 3;5(10):e2236364. doi: 10.1001/jamanetworkopen.2022.36364. PMID: 36227598Free PMC Article
Hontelez S, Stobernack T, Pelsser LM, van Baarlen P, Frankena K, Groefsema MM, Kleerebezem M, Rodrigues Pereira R, Postma EM, Smeets PAM, Stopyra MA, Zwiers MP, Aarts E
Sci Rep 2021 Nov 12;11(1):22205. doi: 10.1038/s41598-021-01684-7. PMID: 34772996Free PMC Article
Salvi V, Migliarese G, Venturi V, Rossi F, Torriero S, Viganò V, Cerveri G, Mencacci C
Riv Psichiatr 2019 Mar-Apr;54(2):84-89. doi: 10.1708/3142.31249. PMID: 30985833
Sprich SE, Safren SA, Finkelstein D, Remmert JE, Hammerness P
J Child Psychol Psychiatry 2016 Nov;57(11):1218-1226. Epub 2016 Mar 17 doi: 10.1111/jcpp.12549. PMID: 26990084Free PMC Article

Recent systematic reviews

Storebø OJ, Storm MRO, Pereira Ribeiro J, Skoog M, Groth C, Callesen HE, Schaug JP, Darling Rasmussen P, Huus CL, Zwi M, Kirubakaran R, Simonsen E, Gluud C
Cochrane Database Syst Rev 2023 Mar 27;3(3):CD009885. doi: 10.1002/14651858.CD009885.pub3. PMID: 36971690Free PMC Article
Siafis S, Çıray O, Wu H, Schneider-Thoma J, Bighelli I, Krause M, Rodolico A, Ceraso A, Deste G, Huhn M, Fraguas D, San José Cáceres A, Mavridis D, Charman T, Murphy DG, Parellada M, Arango C, Leucht S
Mol Autism 2022 Mar 4;13(1):10. doi: 10.1186/s13229-022-00488-4. PMID: 35246237Free PMC Article
GBD 2019 Mental Disorders Collaborators
Lancet Psychiatry 2022 Feb;9(2):137-150. Epub 2022 Jan 10 doi: 10.1016/S2215-0366(21)00395-3. PMID: 35026139Free PMC Article
Ng QX, Ho CYX, Chan HW, Yong BZJ, Yeo WS
Complement Ther Med 2017 Oct;34:123-128. Epub 2017 Aug 31 doi: 10.1016/j.ctim.2017.08.018. PMID: 28917364
Thomas R, Sanders S, Doust J, Beller E, Glasziou P
Pediatrics 2015 Apr;135(4):e994-1001. Epub 2015 Mar 2 doi: 10.1542/peds.2014-3482. PMID: 25733754

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