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Spontaneous chorioamniotic separation

MedGen UID:
1813058
•Concept ID:
C5676638
•
Pathologic Function
Synonym: Amnion-chorion separation
 
HPO: HP:0025712

Definition

Persistence separation of the chorionic and amnionic membranes after the 16th week of gestation (not as a result of a procedure such as amniocentesis). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpontaneous chorioamniotic separation

Conditions with this feature

Restrictive dermopathy 1
MedGen UID:
1812447
•Concept ID:
C5676878
•
Disease or Syndrome
A restrictive dermopathy that has material basis in homozygous or compound heterozygous mutation in the ZMPSTE24 gene on chromosome 1p34.
See: Condition Record
Restrictive dermopathy 1

Recent clinical studies

Etiology

Outcomes of prenatally diagnosed spontaneous chorioamniotic membrane separation in singleton pregnancies: A systematic review of case series and case reports.
Zhu KH, Young BC, Shamshirsaz AA, Espinoza J, Sanz-Cortes M, Donepudi R, Modest AM, Gerson KD, Belfort MA, Nassr AA
Prenat Diagn 2020 Oct;40(11):1366-1374. Epub 2020 Aug 12 doi: 10.1002/pd.5767. PMID: 32533737
North American Fetal Therapy Network: Timing of and indications for delivery following laser ablation for twin-twin transfusion syndrome.
Zaretsky MV, Tong S, Lagueux M, Lim FY, Khalek N, Emery SP, Davis S, Moon-Grady AJ, Drennan K, Treadwell MC, Petersen E, Santiago-Munoz P, Brown R; North American Fetal Therapy Network
Am J Obstet Gynecol MFM 2019 Mar;1(1):74-81. Epub 2019 Mar 27 doi: 10.1016/j.ajogmf.2019.02.001. PMID: 32832884Free PMC Article
Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.
Licci M, Guzman R, Soleman J
Neurosurg Focus 2019 Oct 1;47(4):E11. doi: 10.3171/2019.7.FOCUS19470. PMID: 31574465
In vivo evidence of inflammasome activation during spontaneous labor at term.
Panaitescu B, Romero R, Gomez-Lopez N, Xu Y, Leng Y, Maymon E, Pacora P, Erez O, Yeo L, Hassan SS, Hsu CD
J Matern Fetal Neonatal Med 2019 Jun;32(12):1978-1991. Epub 2018 Jan 17 doi: 10.1080/14767058.2017.1422714. PMID: 29295667Free PMC Article
Separated chorioamnion and elevated chorion: sonographic features and clinical significance.
Kaufman AJ, Fleischer AC, Thieme GA, Shah DM, James AE Jr
J Ultrasound Med 1985 Mar;4(3):119-25. doi: 10.7863/jum.1985.4.3.119. PMID: 3884831

Diagnosis

Outcomes of prenatally diagnosed spontaneous chorioamniotic membrane separation in singleton pregnancies: A systematic review of case series and case reports.
Zhu KH, Young BC, Shamshirsaz AA, Espinoza J, Sanz-Cortes M, Donepudi R, Modest AM, Gerson KD, Belfort MA, Nassr AA
Prenat Diagn 2020 Oct;40(11):1366-1374. Epub 2020 Aug 12 doi: 10.1002/pd.5767. PMID: 32533737
North American Fetal Therapy Network: Timing of and indications for delivery following laser ablation for twin-twin transfusion syndrome.
Zaretsky MV, Tong S, Lagueux M, Lim FY, Khalek N, Emery SP, Davis S, Moon-Grady AJ, Drennan K, Treadwell MC, Petersen E, Santiago-Munoz P, Brown R; North American Fetal Therapy Network
Am J Obstet Gynecol MFM 2019 Mar;1(1):74-81. Epub 2019 Mar 27 doi: 10.1016/j.ajogmf.2019.02.001. PMID: 32832884Free PMC Article
Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.
Licci M, Guzman R, Soleman J
Neurosurg Focus 2019 Oct 1;47(4):E11. doi: 10.3171/2019.7.FOCUS19470. PMID: 31574465
Complete chorioamniotic membrane separation with fetal restrictive dermopathy in two consecutive pregnancies.
Kim YN, Jeong DH, Jeong SJ, Sung MS, Kang MS, Kim KT
Prenat Diagn 2007 Apr;27(4):352-5. doi: 10.1002/pd.1673. PMID: 17286315
Separated chorioamnion and elevated chorion: sonographic features and clinical significance.
Kaufman AJ, Fleischer AC, Thieme GA, Shah DM, James AE Jr
J Ultrasound Med 1985 Mar;4(3):119-25. doi: 10.7863/jum.1985.4.3.119. PMID: 3884831

Therapy

North American Fetal Therapy Network: Timing of and indications for delivery following laser ablation for twin-twin transfusion syndrome.
Zaretsky MV, Tong S, Lagueux M, Lim FY, Khalek N, Emery SP, Davis S, Moon-Grady AJ, Drennan K, Treadwell MC, Petersen E, Santiago-Munoz P, Brown R; North American Fetal Therapy Network
Am J Obstet Gynecol MFM 2019 Mar;1(1):74-81. Epub 2019 Mar 27 doi: 10.1016/j.ajogmf.2019.02.001. PMID: 32832884Free PMC Article
Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.
Licci M, Guzman R, Soleman J
Neurosurg Focus 2019 Oct 1;47(4):E11. doi: 10.3171/2019.7.FOCUS19470. PMID: 31574465
The Management of Myelomeningocele Study: obstetrical outcomes and risk factors for obstetrical complications following prenatal surgery.
Johnson MP, Bennett KA, Rand L, Burrows PK, Thom EA, Howell LJ, Farrell JA, Dabrowiak ME, Brock JW 3rd, Farmer DL, Adzick NS; Management of Myelomeningocele Study Investigators
Am J Obstet Gynecol 2016 Dec;215(6):778.e1-778.e9. Epub 2016 Aug 2 doi: 10.1016/j.ajog.2016.07.052. PMID: 27496687Free PMC Article
Transient chorioamniotic membrane separation after fetoscope guide laser therapy for twin-twin transfusion syndrome: a case report.
Chang YL, Chao AS, Hsieh PC, Chang SD, Soong YK
Fetal Diagn Ther 2007;22(3):180-2. Epub 2007 Jan 16 doi: 10.1159/000098712. PMID: 17228154

Prognosis

Outcomes of prenatally diagnosed spontaneous chorioamniotic membrane separation in singleton pregnancies: A systematic review of case series and case reports.
Zhu KH, Young BC, Shamshirsaz AA, Espinoza J, Sanz-Cortes M, Donepudi R, Modest AM, Gerson KD, Belfort MA, Nassr AA
Prenat Diagn 2020 Oct;40(11):1366-1374. Epub 2020 Aug 12 doi: 10.1002/pd.5767. PMID: 32533737
North American Fetal Therapy Network: Timing of and indications for delivery following laser ablation for twin-twin transfusion syndrome.
Zaretsky MV, Tong S, Lagueux M, Lim FY, Khalek N, Emery SP, Davis S, Moon-Grady AJ, Drennan K, Treadwell MC, Petersen E, Santiago-Munoz P, Brown R; North American Fetal Therapy Network
Am J Obstet Gynecol MFM 2019 Mar;1(1):74-81. Epub 2019 Mar 27 doi: 10.1016/j.ajogmf.2019.02.001. PMID: 32832884Free PMC Article

Clinical prediction guides

North American Fetal Therapy Network: Timing of and indications for delivery following laser ablation for twin-twin transfusion syndrome.
Zaretsky MV, Tong S, Lagueux M, Lim FY, Khalek N, Emery SP, Davis S, Moon-Grady AJ, Drennan K, Treadwell MC, Petersen E, Santiago-Munoz P, Brown R; North American Fetal Therapy Network
Am J Obstet Gynecol MFM 2019 Mar;1(1):74-81. Epub 2019 Mar 27 doi: 10.1016/j.ajogmf.2019.02.001. PMID: 32832884Free PMC Article
Complete chorioamniotic membrane separation with constrictive amniotic band sequence and partial extra-amniotic pregnancy: serial ultrasound documentation and successful fetoscopic intervention.
Schlehe B, Elsässer M, Bosselmann S, Axt-Fliedner R, Sohn C, Kohl T
J Perinatol 2014 Dec;34(12):941-4. doi: 10.1038/jp.2014.159. PMID: 25421128
Different biomechanical properties of human fetal membranes obtained before and after delivery.
Helmig R, Oxlund H, Petersen LK, Uldbjerg N
Eur J Obstet Gynecol Reprod Biol 1993 Mar;48(3):183-9. doi: 10.1016/0028-2243(93)90086-r. PMID: 8335136

Recent systematic reviews

Outcomes of prenatally diagnosed spontaneous chorioamniotic membrane separation in singleton pregnancies: A systematic review of case series and case reports.
Zhu KH, Young BC, Shamshirsaz AA, Espinoza J, Sanz-Cortes M, Donepudi R, Modest AM, Gerson KD, Belfort MA, Nassr AA
Prenat Diagn 2020 Oct;40(11):1366-1374. Epub 2020 Aug 12 doi: 10.1002/pd.5767. PMID: 32533737
Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.
Licci M, Guzman R, Soleman J
Neurosurg Focus 2019 Oct 1;47(4):E11. doi: 10.3171/2019.7.FOCUS19470. PMID: 31574465

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