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Prenatal double bubble sign

MedGen UID:
1813076
•Concept ID:
C5676602
•
Congenital Abnormality
HPO: HP:0025656

Definition

Sonographic detection of a double bubble sign in the upper abdomen is strongly indicative of duodenal obstruction. One bubble represents fetal stomach, and the other is attributed to a dilated proximal part of the duodenum; continuity between both bubbles is required for the sign. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrenatal double bubble sign

Conditions with this feature

Complete trisomy 21 syndrome
MedGen UID:
4385
•Concept ID:
C0013080
•
Disease or Syndrome
Down syndrome, the most frequent form of mental retardation caused by a microscopically demonstrable chromosomal aberration, is characterized by well-defined and distinctive phenotypic features and natural history. It is caused by triplicate state (trisomy) of all or a critical portion of chromosome 21.
See: Condition Record
Complete trisomy 21 syndrome

Professional guidelines

PubMed

Neonatal gastric outlet obstruction by isolated pyloric atresia, an often forgotten diagnosis.
Mboyo A, Clermidi P, Podevin G, Patkowski D, Baglaj M, Gerus S, Lalioui A, Napoli-Cocci Sd, Robert M
Acta Chir Belg 2016 Apr;116(2):89-95. doi: 10.1080/00015458.2016.1156930. PMID: 27385295
Prenatal ultrasonic diagnosis of obstructive bowel disease: a retrospective analysis.
Heydanus R, Spaargaren MC, Wladimiroff JW
Prenat Diagn 1994 Nov;14(11):1035-41. doi: 10.1002/pd.1970141105. PMID: 7877951
Duodenal atresia and stenosis: reassessment of treatment and outcome based on antenatal diagnosis, pathologic variance, and long-term follow-up.
Grosfeld JL, Rescorla FJ
World J Surg 1993 May-Jun;17(3):301-9. doi: 10.1007/BF01658696. PMID: 8337875

Recent clinical studies

Etiology

Clinical significance of prenatal double bubble sign on perinatal outcome and literature review.
Demirci O, Eriç Özdemir M, Kumru P, Celayir A
J Matern Fetal Neonatal Med 2022 May;35(10):1841-1847. Epub 2021 Jan 17 doi: 10.1080/14767058.2021.1874338. PMID: 33455511
The Double Bubble Sign: Duodenal Atresia and Associated Genetic Etiologies.
Bishop JC, McCormick B, Johnson CT, Miller J, Jelin E, Blakemore K, Jelin AC
Fetal Diagn Ther 2020;47(2):98-103. Epub 2019 Jun 5 doi: 10.1159/000500471. PMID: 31167209Free PMC Article
Clinical outcome of pregnancies with the prenatal double bubble sign - a five-year experience from one single centre in mainland China.
Yang Y, He P, Li DZ
J Obstet Gynaecol 2018 Feb;38(2):206-209. Epub 2017 Sep 7 doi: 10.1080/01443615.2017.1342230. PMID: 28880692
Clinical significance of the prenatal double bubble sign - single institution experience.
Kucińska-Chahwan A, Posiewka A, Bijok J, Jakiel G, Roszkowski T
Prenat Diagn 2015 Nov;35(11):1093-6. Epub 2015 Sep 3 doi: 10.1002/pd.4652. PMID: 26175315

Diagnosis

Clinical significance of prenatal double bubble sign on perinatal outcome and literature review.
Demirci O, Eriç Özdemir M, Kumru P, Celayir A
J Matern Fetal Neonatal Med 2022 May;35(10):1841-1847. Epub 2021 Jan 17 doi: 10.1080/14767058.2021.1874338. PMID: 33455511
The Double Bubble Sign: Duodenal Atresia and Associated Genetic Etiologies.
Bishop JC, McCormick B, Johnson CT, Miller J, Jelin E, Blakemore K, Jelin AC
Fetal Diagn Ther 2020;47(2):98-103. Epub 2019 Jun 5 doi: 10.1159/000500471. PMID: 31167209Free PMC Article
Clinical outcome of pregnancies with the prenatal double bubble sign - a five-year experience from one single centre in mainland China.
Yang Y, He P, Li DZ
J Obstet Gynaecol 2018 Feb;38(2):206-209. Epub 2017 Sep 7 doi: 10.1080/01443615.2017.1342230. PMID: 28880692
Clinical significance of the prenatal double bubble sign - single institution experience.
Kucińska-Chahwan A, Posiewka A, Bijok J, Jakiel G, Roszkowski T
Prenat Diagn 2015 Nov;35(11):1093-6. Epub 2015 Sep 3 doi: 10.1002/pd.4652. PMID: 26175315

Prognosis

Clinical significance of prenatal double bubble sign on perinatal outcome and literature review.
Demirci O, Eriç Özdemir M, Kumru P, Celayir A
J Matern Fetal Neonatal Med 2022 May;35(10):1841-1847. Epub 2021 Jan 17 doi: 10.1080/14767058.2021.1874338. PMID: 33455511
The Double Bubble Sign: Duodenal Atresia and Associated Genetic Etiologies.
Bishop JC, McCormick B, Johnson CT, Miller J, Jelin E, Blakemore K, Jelin AC
Fetal Diagn Ther 2020;47(2):98-103. Epub 2019 Jun 5 doi: 10.1159/000500471. PMID: 31167209Free PMC Article

Clinical prediction guides

Clinical significance of prenatal double bubble sign on perinatal outcome and literature review.
Demirci O, Eriç Özdemir M, Kumru P, Celayir A
J Matern Fetal Neonatal Med 2022 May;35(10):1841-1847. Epub 2021 Jan 17 doi: 10.1080/14767058.2021.1874338. PMID: 33455511
The Double Bubble Sign: Duodenal Atresia and Associated Genetic Etiologies.
Bishop JC, McCormick B, Johnson CT, Miller J, Jelin E, Blakemore K, Jelin AC
Fetal Diagn Ther 2020;47(2):98-103. Epub 2019 Jun 5 doi: 10.1159/000500471. PMID: 31167209Free PMC Article

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