U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio

MedGen UID:
1814114
Concept ID:
C5558379
Finding
HPO: HP:0034006

Definition

A decreased amount of the urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) as compared to hydroxylysyl-pyridinoline (HP, or pyridinoline PYD). Both are established biochemical markers of osteoclastic bone resorption and collagen degradation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio

Conditions with this feature

Ehlers-Danlos syndrome, kyphoscoliotic type 1
MedGen UID:
75672
Concept ID:
C0268342
Disease or Syndrome
PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is an autosomal recessive generalized connective tissue disorder characterized by hypotonia, early-onset kyphoscoliosis, and generalized joint hypermobility in association with skin fragility and ocular abnormality. Intelligence is normal. Life span may be normal, but affected individuals are at risk for rupture of medium-sized arteries. Adults with severe kyphoscoliosis are at risk for complications from restrictive lung disease, recurrent pneumonia, and cardiac failure.

Professional guidelines

PubMed

Csikós E, Horváth A, Ács K, Papp N, Balázs VL, Dolenc MS, Kenda M, Kočevar Glavač N, Nagy M, Protti M, Mercolini L, Horváth G, Farkas Á, On Behalf Of The Oemonom
Molecules 2021 Nov 25;26(23) doi: 10.3390/molecules26237141. PMID: 34885733Free PMC Article
Anim-Somuah M, Smyth RM, Cyna AM, Cuthbert A
Cochrane Database Syst Rev 2018 May 21;5(5):CD000331. doi: 10.1002/14651858.CD000331.pub4. PMID: 29781504Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent clinical studies

Etiology

Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Cahn A, Mosenzon O, Wiviott SD, Rozenberg A, Yanuv I, Goodrich EL, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS, Raz I
Diabetes Care 2020 Feb;43(2):468-475. Epub 2019 Dec 16 doi: 10.2337/dc19-1476. PMID: 31843945
Tyson AF, Campbell EF, Spangler LR, Ross SW, Reinke CE, Passaretti CL, Sing RF
J Intensive Care Med 2020 Aug;35(8):738-744. Epub 2018 Jun 10 doi: 10.1177/0885066618781304. PMID: 29886788
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Ashton-Miller JA, DeLancey JO
Ann N Y Acad Sci 2007 Apr;1101:266-96. Epub 2007 Apr 7 doi: 10.1196/annals.1389.034. PMID: 17416924

Diagnosis

Balasubramanian P, Wanner C, Ferreira JP, Ofstad AP, Elsaesser A, Zinman B, Inzucchi SE
J Clin Endocrinol Metab 2022 Jun 16;107(7):e3003-e3007. doi: 10.1210/clinem/dgac154. PMID: 35290464Free PMC Article
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C
Clin Chem 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334Free PMC Article
Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
JAMA Pediatr 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. PMID: 30776077Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Bent S, Nallamothu BK, Simel DL, Fihn SD, Saint S
JAMA 2002 May 22-29;287(20):2701-10. doi: 10.1001/jama.287.20.2701. PMID: 12020306

Therapy

Carvalho PEP, Veiga TMA, Simões E Silva AC, Gewehr DM, Dagostin CS, Fernandes A, Nasi G, Cardoso R
Clin Res Cardiol 2023 Aug;112(8):1044-1055. Epub 2023 Jan 2 doi: 10.1007/s00392-022-02148-2. PMID: 36592186Free PMC Article
Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Woodley SJ, Boyle R, Cody JD, Mørkved S, Hay-Smith EJC
Cochrane Database Syst Rev 2017 Dec 22;12(12):CD007471. doi: 10.1002/14651858.CD007471.pub3. PMID: 29271473Free PMC Article
Jepson RG, Williams G, Craig JC
Cochrane Database Syst Rev 2012 Oct 17;10(10):CD001321. doi: 10.1002/14651858.CD001321.pub5. PMID: 23076891Free PMC Article

Prognosis

Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Cahn A, Mosenzon O, Wiviott SD, Rozenberg A, Yanuv I, Goodrich EL, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS, Raz I
Diabetes Care 2020 Feb;43(2):468-475. Epub 2019 Dec 16 doi: 10.2337/dc19-1476. PMID: 31843945
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article
Popow C, Pollak A, Herkner K, Scheibenreiter S, Swoboda W
Acta Paediatr Scand 1988 Jan;77(1):136-41. doi: 10.1111/j.1651-2227.1988.tb10612.x. PMID: 2967023

Clinical prediction guides

Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Babar A, Moore L, Leblanc V, Dudonné S, Desjardins Y, Lemieux S, Bochard V, Guyonnet D, Dodin S
BMC Urol 2021 Mar 23;21(1):44. doi: 10.1186/s12894-021-00811-w. PMID: 33757474Free PMC Article
Meddings J, Manojlovich M, Ameling JM, Olmsted RN, Rolle AJ, Greene MT, Ratz D, Snyder A, Saint S
Ann Intern Med 2019 Oct 1;171(7_Suppl):S38-S44. doi: 10.7326/M18-3534. PMID: 31569231
Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
JAMA Pediatr 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. PMID: 30776077Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent systematic reviews

Woodley SJ, Lawrenson P, Boyle R, Cody JD, Mørkved S, Kernohan A, Hay-Smith EJC
Cochrane Database Syst Rev 2020 May 6;5(5):CD007471. doi: 10.1002/14651858.CD007471.pub4. PMID: 32378735Free PMC Article
Anim-Somuah M, Smyth RM, Cyna AM, Cuthbert A
Cochrane Database Syst Rev 2018 May 21;5(5):CD000331. doi: 10.1002/14651858.CD000331.pub4. PMID: 29781504Free PMC Article
Woodley SJ, Boyle R, Cody JD, Mørkved S, Hay-Smith EJC
Cochrane Database Syst Rev 2017 Dec 22;12(12):CD007471. doi: 10.1002/14651858.CD007471.pub3. PMID: 29271473Free PMC Article
Avni T, Lador A, Lev S, Leibovici L, Paul M, Grossman A
PLoS One 2015;10(8):e0129305. Epub 2015 Aug 3 doi: 10.1371/journal.pone.0129305. PMID: 26237037Free PMC Article
Jepson RG, Williams G, Craig JC
Cochrane Database Syst Rev 2012 Oct 17;10(10):CD001321. doi: 10.1002/14651858.CD001321.pub5. PMID: 23076891Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...