U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cerebral cortical microinfarct

MedGen UID:
1814213
•Concept ID:
C5676639
•
Disease or Syndrome
HPO: HP:0025714

Definition

An infarct located on the outer layer of the cerebrum that can only be observed microscopically. Cerebral microinfarcts are typically defined as sharply delimited microscopic regions of cellular death or tissue necrosis, sometimes with cavitation (that is, a central fluid-filled cavity). The term microscopic denotes that these lesions are not visible by gross inspection of the brain but seen by light microscopy. The term infarct is most commonly used for ischemia-related tissue loss, and indeed the pathologic appearance of microinfarcts is consistent with that of known ischemic infarctions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral cortical microinfarct

Professional guidelines

PubMed

A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease.
Ringman JM, Sachs MC, Zhou Y, Monsell SE, Saver JL, Vinters HV
JAMA Neurol 2014 Jul 1;71(7):878-83. doi: 10.1001/jamaneurol.2014.681. PMID: 24797962Free PMC Article
Consensus recommendations on pathologic changes in the hippocampus: a postmortem multicenter inter-rater study.
Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I
J Neuropathol Exp Neurol 2013 Jun;72(6):452-61. doi: 10.1097/NEN.0b013e318292492a. PMID: 23656988

Recent clinical studies

Etiology

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Post-Stroke Cognitive Impairment and Dementia.
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
Cerebral Small Vessel Disease.
Rost NS, Etherton M
Continuum (Minneap Minn) 2020 Apr;26(2):332-352. doi: 10.1212/CON.0000000000000841. PMID: 32224755
Cerebrovascular disorders.
Fazekas F, Gattringer T, Enzinger C
Curr Opin Neurol 2018 Aug;31(4):345-353. doi: 10.1097/WCO.0000000000000566. PMID: 29878907

Diagnosis

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Post-Stroke Cognitive Impairment and Dementia.
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Emerging concepts in sporadic cerebral amyloid angiopathy.
Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM
Brain 2017 Jul 1;140(7):1829-1850. doi: 10.1093/brain/awx047. PMID: 28334869Free PMC Article

Therapy

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Assessing cortical cerebral microinfarcts on iron-sensitive MRI in cerebral small vessel disease.
Wiegertjes K, Chan KS, Telgte AT, Gesierich B, Norris DG, Klijn CJ, Duering M, Tuladhar AM, Marques JP, Leeuw FE
J Cereb Blood Flow Metab 2021 Dec;41(12):3391-3399. Epub 2021 Aug 20 doi: 10.1177/0271678X211039609. PMID: 34415209Free PMC Article
Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction.
Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H
EBioMedicine 2018 Jun;32:50-61. Epub 2018 Jun 5 doi: 10.1016/j.ebiom.2018.05.028. PMID: 29880270Free PMC Article
Cerebral Microinfarcts and Dementia: A Systematic Review and Metaanalysis.
Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Yu JT
Curr Alzheimer Res 2017;14(7):802-808. doi: 10.2174/1567205013666161201200429. PMID: 27915996
Associations and implications of cerebral microbleeds.
Kleinig TJ
J Clin Neurosci 2013 Jul;20(7):919-27. Epub 2013 May 24 doi: 10.1016/j.jocn.2012.12.002. PMID: 23707603

Prognosis

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.
Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Post-Stroke Cognitive Impairment and Dementia.
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
Association Between Cerebral Cortical Microinfarcts and Perilesional Cortical Atrophy on 3T MRI.
Ferro DA, Kuijf HJ, Hilal S, van Veluw SJ, van Veldhuizen D, Venketasubramanian N, Tan BY, Biessels GJ, Chen C
Neurology 2022 Feb 8;98(6):e612-e622. Epub 2021 Dec 3 doi: 10.1212/WNL.0000000000013140. PMID: 34862322
Cerebrovascular disorders.
Fazekas F, Gattringer T, Enzinger C
Curr Opin Neurol 2018 Aug;31(4):345-353. doi: 10.1097/WCO.0000000000000566. PMID: 29878907
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Clinical prediction guides

Post-Stroke Cognitive Impairment and Dementia.
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
Association Between Cerebral Cortical Microinfarcts and Perilesional Cortical Atrophy on 3T MRI.
Ferro DA, Kuijf HJ, Hilal S, van Veluw SJ, van Veldhuizen D, Venketasubramanian N, Tan BY, Biessels GJ, Chen C
Neurology 2022 Feb 8;98(6):e612-e622. Epub 2021 Dec 3 doi: 10.1212/WNL.0000000000013140. PMID: 34862322
The new insights into human brain imaging after stroke.
Sagnier S, Sibon I
J Neurosci Res 2022 May;100(5):1171-1181. Epub 2019 Sep 9 doi: 10.1002/jnr.24525. PMID: 31498491
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Associations and implications of cerebral microbleeds.
Kleinig TJ
J Clin Neurosci 2013 Jul;20(7):919-27. Epub 2013 May 24 doi: 10.1016/j.jocn.2012.12.002. PMID: 23707603

Recent systematic reviews

Cerebral small vessel disease and the risk of Alzheimer's disease: A systematic review.
Liu Y, Braidy N, Poljak A, Chan DKY, Sachdev P
Ageing Res Rev 2018 Nov;47:41-48. Epub 2018 Jun 26 doi: 10.1016/j.arr.2018.06.002. PMID: 29898422
Radiological-Pathological Correlation in Alzheimer's Disease: Systematic Review of Antemortem Magnetic Resonance Imaging Findings.
Dallaire-Théroux C, Callahan BL, Potvin O, Saikali S, Duchesne S
J Alzheimers Dis 2017;57(2):575-601. doi: 10.3233/JAD-161028. PMID: 28282807
Cerebral Microinfarcts and Dementia: A Systematic Review and Metaanalysis.
Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Yu JT
Curr Alzheimer Res 2017;14(7):802-808. doi: 10.2174/1567205013666161201200429. PMID: 27915996
Cerebral microinfarcts: a systematic review of neuropathological studies.
Brundel M, de Bresser J, van Dillen JJ, Kappelle LJ, Biessels GJ
J Cereb Blood Flow Metab 2012 Mar;32(3):425-36. Epub 2012 Jan 11 doi: 10.1038/jcbfm.2011.200. PMID: 22234334Free PMC Article
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations.
Gouw AA, Seewann A, van der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJ
J Neurol Neurosurg Psychiatry 2011 Feb;82(2):126-35. Epub 2010 Oct 9 doi: 10.1136/jnnp.2009.204685. PMID: 20935330

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...