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Anti-contactin-associated protein 1 antibody positivity

MedGen UID:
1814303
•Concept ID:
C5676734
•
Finding
Synonym: Anti-CASPR1 antibody positivity
 
HPO: HP:0034138

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-contactin-associated protein 1. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-contactin-associated protein 1 antibody positivity

Recent clinical studies

Etiology

Distinct phenotypes in a cohort of anti-CASPR2 associated neurological syndromes.
Moura J, Samões R, Cardoso M, Sousa AP, Damásio J, Marinho A, Carneiro P, Neves E, Silva AM, Santos E
Clin Neurol Neurosurg 2023 Nov;234:107994. Epub 2023 Sep 30 doi: 10.1016/j.clineuro.2023.107994. PMID: 37797365
Autoimmune neuromyotonia.
Comperat L, Pegat A, Honnorat J, Joubert B
Curr Opin Neurol 2022 Oct 1;35(5):597-603. Epub 2022 Aug 19 doi: 10.1097/WCO.0000000000001104. PMID: 35989569
Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study.
Celicanin M, Blaabjerg M, Maersk-Moller C, Beniczky S, Marner L, Thomsen C, Bach FW, Kondziella D, Andersen H, Somnier F, Illes Z, Pinborg LH
Eur J Neurol 2017 Aug;24(8):999-1005. Epub 2017 May 25 doi: 10.1111/ene.13324. PMID: 28544133
Autoimmune encephalitis with anti-leucine-rich glioma-inactivated 1 or anti-contactin-associated protein-like 2 antibodies (formerly called voltage-gated potassium channel-complex antibodies).
Bastiaansen AEM, van Sonderen A, Titulaer MJ
Curr Opin Neurol 2017 Jun;30(3):302-309. doi: 10.1097/WCO.0000000000000444. PMID: 28248701

Diagnosis

Distinct phenotypes in a cohort of anti-CASPR2 associated neurological syndromes.
Moura J, Samões R, Cardoso M, Sousa AP, Damásio J, Marinho A, Carneiro P, Neves E, Silva AM, Santos E
Clin Neurol Neurosurg 2023 Nov;234:107994. Epub 2023 Sep 30 doi: 10.1016/j.clineuro.2023.107994. PMID: 37797365
Autoimmune neuromyotonia.
Comperat L, Pegat A, Honnorat J, Joubert B
Curr Opin Neurol 2022 Oct 1;35(5):597-603. Epub 2022 Aug 19 doi: 10.1097/WCO.0000000000001104. PMID: 35989569
Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study.
Celicanin M, Blaabjerg M, Maersk-Moller C, Beniczky S, Marner L, Thomsen C, Bach FW, Kondziella D, Andersen H, Somnier F, Illes Z, Pinborg LH
Eur J Neurol 2017 Aug;24(8):999-1005. Epub 2017 May 25 doi: 10.1111/ene.13324. PMID: 28544133
Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case.
Jarius S, Metz I, König FB, Ruprecht K, Reindl M, Paul F, Brück W, Wildemann B
Mult Scler 2016 Oct;22(12):1541-1549. Epub 2016 Feb 11 doi: 10.1177/1352458515622986. PMID: 26869529

Therapy

Morvan Syndrome Converted from Isaacs' Syndrome after Thymectomy with Positivity for Both Anti-LGI1 and Anti-CASPR2 Antibodies.
Suzuki D, Suzuki Y, Sato D, Kikuchi K, Kanauchi N, Nishida A, Ohta Y
Intern Med 2022 May 1;61(9):1443-1445. Epub 2021 Oct 19 doi: 10.2169/internalmedicine.8145-21. PMID: 34670891Free PMC Article
Association between autoimmune encephalitis and epilepsy: Systematic review and meta-analysis.
Chen L, Zhu L, Lu D, Dai S, Han Y, Wu Z, Xu P, Chang L, Wu Q
Seizure 2021 Oct;91:346-359. Epub 2021 Jul 12 doi: 10.1016/j.seizure.2021.07.005. PMID: 34284303

Prognosis

Distinct phenotypes in a cohort of anti-CASPR2 associated neurological syndromes.
Moura J, Samões R, Cardoso M, Sousa AP, Damásio J, Marinho A, Carneiro P, Neves E, Silva AM, Santos E
Clin Neurol Neurosurg 2023 Nov;234:107994. Epub 2023 Sep 30 doi: 10.1016/j.clineuro.2023.107994. PMID: 37797365
Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study.
Celicanin M, Blaabjerg M, Maersk-Moller C, Beniczky S, Marner L, Thomsen C, Bach FW, Kondziella D, Andersen H, Somnier F, Illes Z, Pinborg LH
Eur J Neurol 2017 Aug;24(8):999-1005. Epub 2017 May 25 doi: 10.1111/ene.13324. PMID: 28544133

Clinical prediction guides

Cerebrospinal Fluid Extracellular Vesicles with Distinct Properties in Autoimmune Encephalitis and Herpes Simplex Encephalitis.
Li Y, Gu J, Mao Y, Wang X, Li Z, Xu X, Chen H, Gui Y
Mol Neurobiol 2022 Apr;59(4):2441-2455. Epub 2022 Jan 27 doi: 10.1007/s12035-021-02705-2. PMID: 35083659Free PMC Article
Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study.
Celicanin M, Blaabjerg M, Maersk-Moller C, Beniczky S, Marner L, Thomsen C, Bach FW, Kondziella D, Andersen H, Somnier F, Illes Z, Pinborg LH
Eur J Neurol 2017 Aug;24(8):999-1005. Epub 2017 May 25 doi: 10.1111/ene.13324. PMID: 28544133

Recent systematic reviews

Association between autoimmune encephalitis and epilepsy: Systematic review and meta-analysis.
Chen L, Zhu L, Lu D, Dai S, Han Y, Wu Z, Xu P, Chang L, Wu Q
Seizure 2021 Oct;91:346-359. Epub 2021 Jul 12 doi: 10.1016/j.seizure.2021.07.005. PMID: 34284303

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