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Anti-threonyl-tRNA synthetase antibody positivity

MedGen UID:
1814308
•Concept ID:
C5676739
•
Finding
Synonym: Anti-PL-7 antibody positivity
 
HPO: HP:0034143

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against threonyl-tRNA synthetase. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-threonyl-tRNA synthetase antibody positivity

Recent clinical studies

Etiology

Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
Labirua-Iturburu A, Selva-O'Callaghan A, Vincze M, Dankó K, Vencovsky J, Fisher B, Charles P, Dastmalchi M, Lundberg IE
Medicine (Baltimore) 2012 Jul;91(4):206-211. doi: 10.1097/MD.0b013e318260977c. PMID: 22732951
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies.
O'Hanlon TP, Carrick DM, Targoff IN, Arnett FC, Reveille JD, Carrington M, Gao X, Oddis CV, Morel PA, Malley JD, Malley K, Shamim EA, Rider LG, Chanock SJ, Foster CB, Bunch T, Blackshear PJ, Plotz PH, Love LA, Miller FW
Medicine (Baltimore) 2006 Mar;85(2):111-127. doi: 10.1097/01.md.0000217525.82287.eb. PMID: 16609350

Diagnosis

Analytic and Clinical Validity of Myositis-Specific Antibodies by Line-Blot Immunoassay Is Essential.
Tseng CW, Satoh M, Hasegawa T, Tanaka S, Chen YM
J Clin Rheumatol 2024 Jan 1;30(1):e23-e28. Epub 2023 Nov 20 doi: 10.1097/RHU.0000000000002043. PMID: 37983669
Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease--anti-PL7 positive antisynthetase syndrome: a case report.
De Langhe E, Lenaerts J, Bossuyt X, Westhovens R, Wuyts WA
J Med Case Rep 2015 Apr 15;9:82. doi: 10.1186/s13256-015-0571-2. PMID: 25888844Free PMC Article
Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
Labirua-Iturburu A, Selva-O'Callaghan A, Vincze M, Dankó K, Vencovsky J, Fisher B, Charles P, Dastmalchi M, Lundberg IE
Medicine (Baltimore) 2012 Jul;91(4):206-211. doi: 10.1097/MD.0b013e318260977c. PMID: 22732951
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies.
O'Hanlon TP, Carrick DM, Targoff IN, Arnett FC, Reveille JD, Carrington M, Gao X, Oddis CV, Morel PA, Malley JD, Malley K, Shamim EA, Rider LG, Chanock SJ, Foster CB, Bunch T, Blackshear PJ, Plotz PH, Love LA, Miller FW
Medicine (Baltimore) 2006 Mar;85(2):111-127. doi: 10.1097/01.md.0000217525.82287.eb. PMID: 16609350

Therapy

Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease--anti-PL7 positive antisynthetase syndrome: a case report.
De Langhe E, Lenaerts J, Bossuyt X, Westhovens R, Wuyts WA
J Med Case Rep 2015 Apr 15;9:82. doi: 10.1186/s13256-015-0571-2. PMID: 25888844Free PMC Article
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies.
O'Hanlon TP, Carrick DM, Targoff IN, Arnett FC, Reveille JD, Carrington M, Gao X, Oddis CV, Morel PA, Malley JD, Malley K, Shamim EA, Rider LG, Chanock SJ, Foster CB, Bunch T, Blackshear PJ, Plotz PH, Love LA, Miller FW
Medicine (Baltimore) 2006 Mar;85(2):111-127. doi: 10.1097/01.md.0000217525.82287.eb. PMID: 16609350

Prognosis

Analytic and Clinical Validity of Myositis-Specific Antibodies by Line-Blot Immunoassay Is Essential.
Tseng CW, Satoh M, Hasegawa T, Tanaka S, Chen YM
J Clin Rheumatol 2024 Jan 1;30(1):e23-e28. Epub 2023 Nov 20 doi: 10.1097/RHU.0000000000002043. PMID: 37983669
Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease--anti-PL7 positive antisynthetase syndrome: a case report.
De Langhe E, Lenaerts J, Bossuyt X, Westhovens R, Wuyts WA
J Med Case Rep 2015 Apr 15;9:82. doi: 10.1186/s13256-015-0571-2. PMID: 25888844Free PMC Article
Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
Labirua-Iturburu A, Selva-O'Callaghan A, Vincze M, Dankó K, Vencovsky J, Fisher B, Charles P, Dastmalchi M, Lundberg IE
Medicine (Baltimore) 2012 Jul;91(4):206-211. doi: 10.1097/MD.0b013e318260977c. PMID: 22732951

Clinical prediction guides

Analytic and Clinical Validity of Myositis-Specific Antibodies by Line-Blot Immunoassay Is Essential.
Tseng CW, Satoh M, Hasegawa T, Tanaka S, Chen YM
J Clin Rheumatol 2024 Jan 1;30(1):e23-e28. Epub 2023 Nov 20 doi: 10.1097/RHU.0000000000002043. PMID: 37983669

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