U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anti-glycyl tRNA-synthetase antibody positivity

MedGen UID:
1814311
•Concept ID:
C5676742
•
Finding
Synonym: Anti-EJ antibody positivity
 
HPO: HP:0034146

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glycyl tRNA-synthetase. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-glycyl tRNA-synthetase antibody positivity

Recent clinical studies

Etiology

Clinical features and outcomes of the patients with anti-glycyl tRNA synthetase syndrome.
Zhang Y, Ge Y, Yang H, Chen H, Tian X, Huang Z, Liu S, Lu X, Wang G
Clin Rheumatol 2020 Aug;39(8):2417-2424. Epub 2020 Mar 6 doi: 10.1007/s10067-020-04979-8. PMID: 32144624
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.
Sasano H, Hagiwara E, Kitamura H, Enomoto Y, Matsuo N, Baba T, Iso S, Okudela K, Iwasawa T, Sato S, Suzuki Y, Takemura T, Ogura T
BMC Pulm Med 2016 Dec 1;16(1):168. doi: 10.1186/s12890-016-0325-y. PMID: 27903248Free PMC Article
Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease.
Hane H, Muro Y, Watanabe K, Ogawa Y, Sugiura K, Akiyama M
Clin Chim Acta 2014 Apr 20;431:9-14. Epub 2014 Feb 5 doi: 10.1016/j.cca.2014.01.005. PMID: 24508626

Diagnosis

Unilateral Autoimmune Pulmonary Alveolar Proteinosis with Polymyositis-related Interstitial Lung Disease.
Muto Y, Hagiwara E, Baba T, Sato Y, Sakayori M, Tabata E, Sekine A, Komatsu S, Okudela K, Sayama K, Ogura T
Intern Med 2022 Oct 15;61(20):3095-3100. Epub 2022 Apr 2 doi: 10.2169/internalmedicine.9015-21. PMID: 35370233Free PMC Article
Anti-EJ Antibody-positive Anti-synthetase Syndrome Associated with Retroperitoneal Sarcoma.
Fukui S, Kobayashi K, Fujita Y, Fukui S, Iwamoto N, Adachi T, Hidaka M, Takatsuki M, Abe K, Kuwana M, Kawakami A, Eguchi S
Intern Med 2020 Aug 15;59(16):2071-2076. Epub 2020 May 23 doi: 10.2169/internalmedicine.3923-19. PMID: 32448829Free PMC Article
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.
Sasano H, Hagiwara E, Kitamura H, Enomoto Y, Matsuo N, Baba T, Iso S, Okudela K, Iwasawa T, Sato S, Suzuki Y, Takemura T, Ogura T
BMC Pulm Med 2016 Dec 1;16(1):168. doi: 10.1186/s12890-016-0325-y. PMID: 27903248Free PMC Article
Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease.
Hane H, Muro Y, Watanabe K, Ogawa Y, Sugiura K, Akiyama M
Clin Chim Acta 2014 Apr 20;431:9-14. Epub 2014 Feb 5 doi: 10.1016/j.cca.2014.01.005. PMID: 24508626

Therapy

Clinical features and outcomes of the patients with anti-glycyl tRNA synthetase syndrome.
Zhang Y, Ge Y, Yang H, Chen H, Tian X, Huang Z, Liu S, Lu X, Wang G
Clin Rheumatol 2020 Aug;39(8):2417-2424. Epub 2020 Mar 6 doi: 10.1007/s10067-020-04979-8. PMID: 32144624
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.
Sasano H, Hagiwara E, Kitamura H, Enomoto Y, Matsuo N, Baba T, Iso S, Okudela K, Iwasawa T, Sato S, Suzuki Y, Takemura T, Ogura T
BMC Pulm Med 2016 Dec 1;16(1):168. doi: 10.1186/s12890-016-0325-y. PMID: 27903248Free PMC Article

Prognosis

Anti-EJ Antibody-positive Anti-synthetase Syndrome Associated with Retroperitoneal Sarcoma.
Fukui S, Kobayashi K, Fujita Y, Fukui S, Iwamoto N, Adachi T, Hidaka M, Takatsuki M, Abe K, Kuwana M, Kawakami A, Eguchi S
Intern Med 2020 Aug 15;59(16):2071-2076. Epub 2020 May 23 doi: 10.2169/internalmedicine.3923-19. PMID: 32448829Free PMC Article
Clinical features and outcomes of the patients with anti-glycyl tRNA synthetase syndrome.
Zhang Y, Ge Y, Yang H, Chen H, Tian X, Huang Z, Liu S, Lu X, Wang G
Clin Rheumatol 2020 Aug;39(8):2417-2424. Epub 2020 Mar 6 doi: 10.1007/s10067-020-04979-8. PMID: 32144624
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.
Sasano H, Hagiwara E, Kitamura H, Enomoto Y, Matsuo N, Baba T, Iso S, Okudela K, Iwasawa T, Sato S, Suzuki Y, Takemura T, Ogura T
BMC Pulm Med 2016 Dec 1;16(1):168. doi: 10.1186/s12890-016-0325-y. PMID: 27903248Free PMC Article

Clinical prediction guides

Anti-EJ Antibody-positive Anti-synthetase Syndrome Associated with Retroperitoneal Sarcoma.
Fukui S, Kobayashi K, Fujita Y, Fukui S, Iwamoto N, Adachi T, Hidaka M, Takatsuki M, Abe K, Kuwana M, Kawakami A, Eguchi S
Intern Med 2020 Aug 15;59(16):2071-2076. Epub 2020 May 23 doi: 10.2169/internalmedicine.3923-19. PMID: 32448829Free PMC Article
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.
Sasano H, Hagiwara E, Kitamura H, Enomoto Y, Matsuo N, Baba T, Iso S, Okudela K, Iwasawa T, Sato S, Suzuki Y, Takemura T, Ogura T
BMC Pulm Med 2016 Dec 1;16(1):168. doi: 10.1186/s12890-016-0325-y. PMID: 27903248Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...