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Anti-phenylalanyl tRNA synthetase antibody positivity

MedGen UID:
1814314
•Concept ID:
C5676745
•
Finding
Synonyms: Anti-Zo alpha antibody positivity; Anti-Zo antibody positivity; Phenylanyl-t-RNA synthetase alpha antibody positivity
 
HPO: HP:0034149

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phenylalanyl tRNA synthetase. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-phenylalanyl tRNA synthetase antibody positivity

Professional guidelines

PubMed

The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
Management of Myositis-Associated Interstitial Lung Disease.
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Anti-aminoacyl-tRNA synthetase-related myositis and dermatomyositis: clues for differential diagnosis on muscle biopsy.
Cerbelli B, Pisano A, Colafrancesco S, Pignataro MG, Biffoni M, Berni S, De Luca A, Riccieri V, Priori R, Valesini G, d'Amati G, Giordano C
Virchows Arch 2018 Mar;472(3):477-487. Epub 2017 Nov 16 doi: 10.1007/s00428-017-2269-x. PMID: 29147923

Recent clinical studies

Etiology

The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
The clinical features and prognoses of anti-MDA5 and anti-aminoacyl-tRNA synthetase antibody double-positive dermatomyositis patients.
Chen X, Zhang L, Jin Q, Lu X, Lei J, Peng Q, Wang G, Ge Y
Front Immunol 2022;13:987841. Epub 2022 Aug 30 doi: 10.3389/fimmu.2022.987841. PMID: 36110863Free PMC Article
Clinical characteristics of anti-isoleucyl-tRNA synthetase antibody associated syndrome and comparison with different patient cohorts.
Ge YP, Zhang YL, Shu XM, Lu X, Wang GC
Clin Exp Rheumatol 2022 Mar;40(3):625-630. Epub 2021 Jun 8 doi: 10.55563/clinexprheumatol/v2rbd0. PMID: 34128807
Anti-tRNA synthetase syndrome interstitial lung disease: A single center experience.
Wilfong EM, Young-Glazer JJ, Sohn BK, Schroeder G, Annapureddy N, Gillaspie EA, Barnado A, Crofford LJ, Dudenhofer RB
Respir Med 2022 Jan;191:106432. Epub 2021 May 4 doi: 10.1016/j.rmed.2021.106432. PMID: 33994288Free PMC Article
Management of Myositis-Associated Interstitial Lung Disease.
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article

Diagnosis

The clinical features and prognoses of anti-MDA5 and anti-aminoacyl-tRNA synthetase antibody double-positive dermatomyositis patients.
Chen X, Zhang L, Jin Q, Lu X, Lei J, Peng Q, Wang G, Ge Y
Front Immunol 2022;13:987841. Epub 2022 Aug 30 doi: 10.3389/fimmu.2022.987841. PMID: 36110863Free PMC Article
Anti-tRNA synthetase syndrome interstitial lung disease: A single center experience.
Wilfong EM, Young-Glazer JJ, Sohn BK, Schroeder G, Annapureddy N, Gillaspie EA, Barnado A, Crofford LJ, Dudenhofer RB
Respir Med 2022 Jan;191:106432. Epub 2021 May 4 doi: 10.1016/j.rmed.2021.106432. PMID: 33994288Free PMC Article
Myositis autoantibodies: recent perspectives.
Riddell V, Bagby S, McHugh N
Curr Opin Rheumatol 2020 Nov;32(6):548-552. doi: 10.1097/BOR.0000000000000742. PMID: 32890028
Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.
Shioya S, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N
Respir Med 2019 Jun;152:44-50. Epub 2019 May 1 doi: 10.1016/j.rmed.2019.04.023. PMID: 31128609
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Therapy

Combination of Prednisolone and Calcineurin Inhibitors Prevents Lung Function Decline in Patients with Anti-aminoacyl-tRNA Synthetase Antibody-Positive Polymyositis/Dermatomyositis.
Yorishima Y, Tominaga M, Fujimoto K, Nagata S, Sumi A, Chikasue T, Okamoto M, Kaieda S, Matama G, Zaizen Y, Obara H, Kakuma T, Ida H, Kawayama T, Hoshino T
Kurume Med J 2023 Nov 30;69(1.2):19-30. Epub 2023 Aug 7 doi: 10.2739/kurumemedj.MS6912002. PMID: 37544752
The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
High-Resolution CT Findings of Myositis-Related Interstitial Lung Disease.
Egashira R
Medicina (Kaunas) 2021 Jul 6;57(7) doi: 10.3390/medicina57070692. PMID: 34356972Free PMC Article
Clinical features and outcomes of the patients with anti-glycyl tRNA synthetase syndrome.
Zhang Y, Ge Y, Yang H, Chen H, Tian X, Huang Z, Liu S, Lu X, Wang G
Clin Rheumatol 2020 Aug;39(8):2417-2424. Epub 2020 Mar 6 doi: 10.1007/s10067-020-04979-8. PMID: 32144624
Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.
Shioya S, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N
Respir Med 2019 Jun;152:44-50. Epub 2019 May 1 doi: 10.1016/j.rmed.2019.04.023. PMID: 31128609

Prognosis

The clinical features and prognoses of anti-MDA5 and anti-aminoacyl-tRNA synthetase antibody double-positive dermatomyositis patients.
Chen X, Zhang L, Jin Q, Lu X, Lei J, Peng Q, Wang G, Ge Y
Front Immunol 2022;13:987841. Epub 2022 Aug 30 doi: 10.3389/fimmu.2022.987841. PMID: 36110863Free PMC Article
High-Resolution CT Findings of Myositis-Related Interstitial Lung Disease.
Egashira R
Medicina (Kaunas) 2021 Jul 6;57(7) doi: 10.3390/medicina57070692. PMID: 34356972Free PMC Article
Management of Myositis-Associated Interstitial Lung Disease.
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.
Shioya S, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N
Respir Med 2019 Jun;152:44-50. Epub 2019 May 1 doi: 10.1016/j.rmed.2019.04.023. PMID: 31128609
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Clinical prediction guides

Anti-tRNA synthetase syndrome interstitial lung disease: A single center experience.
Wilfong EM, Young-Glazer JJ, Sohn BK, Schroeder G, Annapureddy N, Gillaspie EA, Barnado A, Crofford LJ, Dudenhofer RB
Respir Med 2022 Jan;191:106432. Epub 2021 May 4 doi: 10.1016/j.rmed.2021.106432. PMID: 33994288Free PMC Article
Management of Myositis-Associated Interstitial Lung Disease.
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Anti-EJ Antibody-positive Anti-synthetase Syndrome Associated with Retroperitoneal Sarcoma.
Fukui S, Kobayashi K, Fujita Y, Fukui S, Iwamoto N, Adachi T, Hidaka M, Takatsuki M, Abe K, Kuwana M, Kawakami A, Eguchi S
Intern Med 2020 Aug 15;59(16):2071-2076. Epub 2020 May 23 doi: 10.2169/internalmedicine.3923-19. PMID: 32448829Free PMC Article
Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.
Shioya S, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N
Respir Med 2019 Jun;152:44-50. Epub 2019 May 1 doi: 10.1016/j.rmed.2019.04.023. PMID: 31128609
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Recent systematic reviews

A Systematic Review and Metaanalysis of Predictors of Mortality in Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease.
Hannah JR, Law HE, Gordon T, Rooney M, Buazon A, Adas M, Nagra D, Stovin C, Galloway J, Gordon PA
J Rheumatol 2023 Mar;50(3):373-383. Epub 2022 Sep 1 doi: 10.3899/jrheum.220383. PMID: 36379584
The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345

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