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Anti-histidyl tRNA synthetase antibody positivity

MedGen UID:
1814317
•Concept ID:
C5676748
•
Finding
Synonym: Anti-Jo-1 antibody positivity
 
HPO: HP:0034152

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against histidyl tRNA synthetase. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-histidyl tRNA synthetase antibody positivity

Professional guidelines

PubMed

Treatment of antisynthetase-associated interstitial lung disease with tacrolimus.
Wilkes MR, Sereika SM, Fertig N, Lucas MR, Oddis CV
Arthritis Rheum 2005 Aug;52(8):2439-46. doi: 10.1002/art.21240. PMID: 16052580

Recent clinical studies

Etiology

A New Immunodot Assay for Multiplex Detection of Autoantibodies in a Cohort of Italian Patients With Idiopathic Inflammatory Myopathies.
Tampoia M, Notarnicola A, Abbracciavento L, Fontana A, Giannini M, Louis Humbel R, Iannone F
J Clin Lab Anal 2016 Nov;30(6):859-866. Epub 2016 Apr 13 doi: 10.1002/jcla.21948. PMID: 27074881Free PMC Article
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.
Miller FW, Chen W, O'Hanlon TP, Cooper RG, Vencovsky J, Rider LG, Danko K, Wedderburn LR, Lundberg IE, Pachman LM, Reed AM, Ytterberg SR, Padyukov L, Selva-O'Callaghan A, Radstake TR, Isenberg DA, Chinoy H, Ollier WE, Scheet P, Peng B, Lee A, Byun J, Lamb JA, Gregersen PK, Amos CI; Myositis Genetics Consortium
Genes Immun 2015 Oct;16(7):470-80. Epub 2015 Aug 20 doi: 10.1038/gene.2015.28. PMID: 26291516Free PMC Article
Entering a new phase of immunogenetics in the idiopathic inflammatory myopathies.
Rothwell S, Cooper RG, Lamb JA, Chinoy H
Curr Opin Rheumatol 2013 Nov;25(6):735-41. doi: 10.1097/01.bor.0000434676.70268.66. PMID: 24067379
Treatment of antisynthetase-associated interstitial lung disease with tacrolimus.
Wilkes MR, Sereika SM, Fertig N, Lucas MR, Oddis CV
Arthritis Rheum 2005 Aug;52(8):2439-46. doi: 10.1002/art.21240. PMID: 16052580
Scleroderma overlap syndromes.
Jablonska S, Blaszczyk M
Adv Exp Med Biol 1999;455:85-92. doi: 10.1007/978-1-4615-4857-7_12. PMID: 10599327

Diagnosis

Analytic and Clinical Validity of Myositis-Specific Antibodies by Line-Blot Immunoassay Is Essential.
Tseng CW, Satoh M, Hasegawa T, Tanaka S, Chen YM
J Clin Rheumatol 2024 Jan 1;30(1):e23-e28. Epub 2023 Nov 20 doi: 10.1097/RHU.0000000000002043. PMID: 37983669
A New Immunodot Assay for Multiplex Detection of Autoantibodies in a Cohort of Italian Patients With Idiopathic Inflammatory Myopathies.
Tampoia M, Notarnicola A, Abbracciavento L, Fontana A, Giannini M, Louis Humbel R, Iannone F
J Clin Lab Anal 2016 Nov;30(6):859-866. Epub 2016 Apr 13 doi: 10.1002/jcla.21948. PMID: 27074881Free PMC Article
Development of antisynthetase syndrome in a patient with rheumatoid arthritis.
Park CK, Kim TJ, Cho YN, Kim IS, Lee HJ, Lee KE, Park SC, Kim JS, Park DJ, Lee SJ, Seo SR, Kim JC, Song SG, Lee SS, Park YW
Rheumatol Int 2011 Apr;31(4):529-32. Epub 2009 Oct 22 doi: 10.1007/s00296-009-1222-y. PMID: 19847427

Therapy

Interstitial lung disease is a dominant feature in patients with circulating myositis-specific antibodies.
Misra AK, Wong NL, Healey TT, Lally EV, Shea BS
BMC Pulm Med 2021 Nov 14;21(1):370. doi: 10.1186/s12890-021-01737-7. PMID: 34775966Free PMC Article
Treatment of antisynthetase-associated interstitial lung disease with tacrolimus.
Wilkes MR, Sereika SM, Fertig N, Lucas MR, Oddis CV
Arthritis Rheum 2005 Aug;52(8):2439-46. doi: 10.1002/art.21240. PMID: 16052580

Prognosis

Analytic and Clinical Validity of Myositis-Specific Antibodies by Line-Blot Immunoassay Is Essential.
Tseng CW, Satoh M, Hasegawa T, Tanaka S, Chen YM
J Clin Rheumatol 2024 Jan 1;30(1):e23-e28. Epub 2023 Nov 20 doi: 10.1097/RHU.0000000000002043. PMID: 37983669
Scleroderma overlap syndromes.
Jablonska S, Blaszczyk M
Adv Exp Med Biol 1999;455:85-92. doi: 10.1007/978-1-4615-4857-7_12. PMID: 10599327

Clinical prediction guides

Analytic and Clinical Validity of Myositis-Specific Antibodies by Line-Blot Immunoassay Is Essential.
Tseng CW, Satoh M, Hasegawa T, Tanaka S, Chen YM
J Clin Rheumatol 2024 Jan 1;30(1):e23-e28. Epub 2023 Nov 20 doi: 10.1097/RHU.0000000000002043. PMID: 37983669
A New Immunodot Assay for Multiplex Detection of Autoantibodies in a Cohort of Italian Patients With Idiopathic Inflammatory Myopathies.
Tampoia M, Notarnicola A, Abbracciavento L, Fontana A, Giannini M, Louis Humbel R, Iannone F
J Clin Lab Anal 2016 Nov;30(6):859-866. Epub 2016 Apr 13 doi: 10.1002/jcla.21948. PMID: 27074881Free PMC Article
Treatment of antisynthetase-associated interstitial lung disease with tacrolimus.
Wilkes MR, Sereika SM, Fertig N, Lucas MR, Oddis CV
Arthritis Rheum 2005 Aug;52(8):2439-46. doi: 10.1002/art.21240. PMID: 16052580

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