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Anti-beta-2-Glycoprotein I IgG antibody positivity

MedGen UID:
1814321
•Concept ID:
C5676752
•
Laboratory or Test Result
Synonym: Anti-beta2GPI IgG antibody positivity
 
HPO: HP:0034156

Definition

Presence of IgG antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-beta-2-Glycoprotein I IgG antibody positivity

Conditions with this feature

Proteasome-associated autoinflammatory syndrome 2
MedGen UID:
1648482
•Concept ID:
C4747989
•
Disease or Syndrome
Proteasome-associated autoinflammatory syndrome-2 (PRAAS2) is an autosomal dominant disorder with onset in early infancy. Affected individuals develop severe inflammatory neutrophilic dermatitis, autoimmunity, and variable immunodeficiency (summary by Poli et al., 2018). For a discussion of genetic heterogeneity of PRAAS, see PRAAS1 (256040).
See: Condition Record
Proteasome-associated autoinflammatory syndrome 2

Professional guidelines

PubMed

Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.
Sloan EE, Kmetova K, NaveenKumar SK, Kluge L, Chong E, Hoy CK, Yalavarthi S, Sarosh C, Baisch J, Walters L, Nassi L, Fuller J, Turnier JL, Pascual V, Wright TB, Madison JA, Knight JS, Zia A, Zuo Y
Clin Immunol 2024 Apr;261:109926. Epub 2024 Feb 13 doi: 10.1016/j.clim.2024.109926. PMID: 38355030
2023 ACR/EULAR antiphospholipid syndrome classification criteria.
Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, Amoura Z, Andrade D, Andreoli L, Artim-Esen B, Atsumi T, Avcin T, Belmont HM, Bertolaccini ML, Branch DW, Carvalheiras G, Casini A, Cervera R, Cohen H, Costedoat-Chalumeau N, Crowther M, de Jesús G, Delluc A, Desai S, Sancho M, Devreese KM, Diz-Kucukkaya R, Duarte-García A, Frances C, Garcia D, Gris JC, Jordan N, Leaf RK, Kello N, Knight JS, Laskin C, Lee AI, Legault K, Levine SR, Levy RA, Limper M, Lockshin MD, Mayer-Pickel K, Musial J, Meroni PL, Orsolini G, Ortel TL, Pengo V, Petri M, Pons-Estel G, Gomez-Puerta JA, Raimboug Q, Roubey R, Sanna G, Seshan SV, Sciascia S, Tektonidou MG, Tincani A, Wahl D, Willis R, Yelnik C, Zuily C, Guillemin F, Costenbader K, Erkan D; ACR/EULAR APS Classification Criteria Collaborators
Ann Rheum Dis 2023 Oct;82(10):1258-1270. Epub 2023 Aug 28 doi: 10.1136/ard-2023-224609. PMID: 37640450
The 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria.
Barbhaiya M, Zuily S, Naden R, Hendry A, Manneville F, Amigo MC, Amoura Z, Andrade D, Andreoli L, Artim-Esen B, Atsumi T, Avcin T, Belmont HM, Bertolaccini ML, Branch DW, Carvalheiras G, Casini A, Cervera R, Cohen H, Costedoat-Chalumeau N, Crowther M, de Jesus G, Delluc A, Desai S, De Sancho M, Devreese KM, Diz-Kucukkaya R, Duarte-Garcia A, Frances C, Garcia D, Gris JC, Jordan N, Leaf RK, Kello N, Knight JS, Laskin C, Lee AI, Legault K, Levine SR, Levy RA, Limper M, Lockshin MD, Mayer-Pickel K, Musial J, Meroni PL, Orsolini G, Ortel TL, Pengo V, Petri M, Pons-Estel G, Gomez-Puerta JA, Raimboug Q, Roubey R, Sanna G, Seshan SV, Sciascia S, Tektonidou MG, Tincani A, Wahl D, Willis R, Yelnik C, Zuily C, Guillemin F, Costenbader K, Erkan D; ACR/EULAR APS Classification Criteria Collaborators
Arthritis Rheumatol 2023 Oct;75(10):1687-1702. Epub 2023 Aug 28 doi: 10.1002/art.42624. PMID: 37635643

Recent systematic reviews

Increased risk of acute and chronic microvascular renal lesions associated with antiphospholipid antibodies in patients with systemic lupus erythematosus: A systematic review and meta-analysis.
Domingues V, Chock EY, Dufrost V, Risse J, Seshan SV, Barbhaiya M, Sartelet H, Erkan D, Wahl D, Zuily S
Autoimmun Rev 2022 Oct;21(10):103158. Epub 2022 Jul 28 doi: 10.1016/j.autrev.2022.103158. PMID: 35907609
A systematic review of the association between anti-β-2 glycoprotein I antibodies and APS manifestations.
Jiang D, Lim W, Crowther M, Garcia D
Blood Adv 2021 Oct 26;5(20):3931-3936. doi: 10.1182/bloodadvances.2021005205. PMID: 34547773Free PMC Article
Systematic Review of Antiphospholipid Antibodies in COVID-19 Patients: Culprits or Bystanders?
Foret T, Dufrost V, Salomon Du Mont L, Costa P, Lefevre B, Lacolley P, Regnault V, Zuily S, Wahl D
Curr Rheumatol Rep 2021 Jul 3;23(8):65. doi: 10.1007/s11926-021-01029-3. PMID: 34218350Free PMC Article
Relevance of antiphospholipid antibodies in multiple sclerosis: A systematic review and meta analysis.
Merashli M, Alves JD, Gentile F, Ames PRJ
Semin Arthritis Rheum 2017 Jun;46(6):810-818. Epub 2016 Oct 3 doi: 10.1016/j.semarthrit.2016.09.010. PMID: 27908533
Clinical relevance of antiphospholipid antibodies in systemic sclerosis: A systematic review and meta-analysis.
Merashli M, Alves J, Ames PRJ
Semin Arthritis Rheum 2017 Apr;46(5):615-624. Epub 2016 Oct 13 doi: 10.1016/j.semarthrit.2016.10.004. PMID: 27838012

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