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Anti-thyroid-stimulating hormone receptor antibody positivity

MedGen UID:
1814349
•Concept ID:
C5676780
•
Finding
Synonyms: Anti-thyrotropin receptor antibody; Anti-TSH receptor antibody positivity; TRAbs
 
HPO: HP:0034189

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid-stimulating hormone. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-thyroid-stimulating hormone receptor antibody positivity

Conditions with this feature

Thyroid hormone resistance, generalized, autosomal recessive
MedGen UID:
483749
•Concept ID:
C3489796
•
Disease or Syndrome
A rare, autosomal recessive inherited disorder usually caused by mutations in the THRB gene. It is characterized by a defective physiological resistance to thyroid hormones, resulting in the elevation of thyroxin and triiodothyronine in the serum.
See: Condition Record
Thyroid hormone resistance, generalized, autosomal recessive

Professional guidelines

PubMed

Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment.
Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K
Am J Perinatol 1988 Apr;5(2):152-8. doi: 10.1055/s-2007-999676. PMID: 2450549

Recent clinical studies

Etiology

Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors.
Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL
Endocrinol Metab (Seoul) 2021 Jun;36(3):582-589. Epub 2021 Jun 8 doi: 10.3803/EnM.2021.983. PMID: 34107601Free PMC Article
Circulating epithelial cells as potential biomarkers for detection of recurrence in patients of papillary thyroid carcinoma with positive serum anti-thyroglobulin antibody.
Li YR, Tseng CP, Hsu HL, Lin HC, Chen YA, Chen ST, Liou MJ, Lin JD
Clin Chim Acta 2018 Feb;477:74-80. Epub 2017 Dec 8 doi: 10.1016/j.cca.2017.12.011. PMID: 29229463
Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment.
Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K
Am J Perinatol 1988 Apr;5(2):152-8. doi: 10.1055/s-2007-999676. PMID: 2450549

Diagnosis

Graves' disease coexisted with resistance to thyroid hormone: a case report.
Akahori H, Usuda R
J Med Case Rep 2021 Sep 25;15(1):473. doi: 10.1186/s13256-021-03061-4. PMID: 34560890Free PMC Article
Anti-Thyroid Peroxidase/Anti-Thyroglobulin Antibody-Related Neurologic Disorder Responsive to Steroids Presenting with Pure Acute Onset Chorea.
Ghosh R, Chatterjee S, Dubey S, Pandit A, Ray BK, Benito-León J
Tremor Other Hyperkinet Mov (N Y) 2020 Jul 8;10:19. doi: 10.5334/tohm.175. PMID: 32775033Free PMC Article
Circulating epithelial cells as potential biomarkers for detection of recurrence in patients of papillary thyroid carcinoma with positive serum anti-thyroglobulin antibody.
Li YR, Tseng CP, Hsu HL, Lin HC, Chen YA, Chen ST, Liou MJ, Lin JD
Clin Chim Acta 2018 Feb;477:74-80. Epub 2017 Dec 8 doi: 10.1016/j.cca.2017.12.011. PMID: 29229463
Thyrotropin-producing pituitary adenoma simultaneously existing with Graves' disease: a case report.
Arai N, Inaba M, Ichijyo T, Kagami H, Mine Y
J Med Case Rep 2017 Jan 6;11(1):9. doi: 10.1186/s13256-016-1172-4. PMID: 28061802Free PMC Article
Determination of the levels of anti-thyroid-stimulating hormone receptor antibody with thyroid peroxidase antibody in Omani patients with Graves' disease.
Alnaqdy A, Al-Maskari M
Med Princ Pract 2005 Jul-Aug;14(4):209-12. doi: 10.1159/000085736. PMID: 15961927

Therapy

Graves' disease coexisted with resistance to thyroid hormone: a case report.
Akahori H, Usuda R
J Med Case Rep 2021 Sep 25;15(1):473. doi: 10.1186/s13256-021-03061-4. PMID: 34560890Free PMC Article
Anti-Thyroid Peroxidase/Anti-Thyroglobulin Antibody-Related Neurologic Disorder Responsive to Steroids Presenting with Pure Acute Onset Chorea.
Ghosh R, Chatterjee S, Dubey S, Pandit A, Ray BK, Benito-León J
Tremor Other Hyperkinet Mov (N Y) 2020 Jul 8;10:19. doi: 10.5334/tohm.175. PMID: 32775033Free PMC Article
Follicle-stimulating Hormone-secreting Pituitary Adenoma Accompanied by Painful Thyroiditis.
Ichijo M, Tsuchiya K, Kasai T, Inoshita N, Yoshimoto H, Yamada S, Kitamura K
Intern Med 2020 Feb 15;59(4):545-550. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.3667-19. PMID: 31611532Free PMC Article
Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment.
Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K
Am J Perinatol 1988 Apr;5(2):152-8. doi: 10.1055/s-2007-999676. PMID: 2450549

Prognosis

Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors.
Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL
Endocrinol Metab (Seoul) 2021 Jun;36(3):582-589. Epub 2021 Jun 8 doi: 10.3803/EnM.2021.983. PMID: 34107601Free PMC Article
Follicle-stimulating Hormone-secreting Pituitary Adenoma Accompanied by Painful Thyroiditis.
Ichijo M, Tsuchiya K, Kasai T, Inoshita N, Yoshimoto H, Yamada S, Kitamura K
Intern Med 2020 Feb 15;59(4):545-550. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.3667-19. PMID: 31611532Free PMC Article
Circulating epithelial cells as potential biomarkers for detection of recurrence in patients of papillary thyroid carcinoma with positive serum anti-thyroglobulin antibody.
Li YR, Tseng CP, Hsu HL, Lin HC, Chen YA, Chen ST, Liou MJ, Lin JD
Clin Chim Acta 2018 Feb;477:74-80. Epub 2017 Dec 8 doi: 10.1016/j.cca.2017.12.011. PMID: 29229463
Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment.
Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K
Am J Perinatol 1988 Apr;5(2):152-8. doi: 10.1055/s-2007-999676. PMID: 2450549

Clinical prediction guides

Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors.
Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL
Endocrinol Metab (Seoul) 2021 Jun;36(3):582-589. Epub 2021 Jun 8 doi: 10.3803/EnM.2021.983. PMID: 34107601Free PMC Article
Sight-Threatening Graves' Ophthalmopathy during the Third Trimester of Pregnancy: A Case Report.
Sakurai K, Inoue T, Niitsuma S, Sato R, Takahashi K, Arihara Z
Tohoku J Exp Med 2020 Dec;252(4):321-327. doi: 10.1620/tjem.252.321. PMID: 33268601
Circulating epithelial cells as potential biomarkers for detection of recurrence in patients of papillary thyroid carcinoma with positive serum anti-thyroglobulin antibody.
Li YR, Tseng CP, Hsu HL, Lin HC, Chen YA, Chen ST, Liou MJ, Lin JD
Clin Chim Acta 2018 Feb;477:74-80. Epub 2017 Dec 8 doi: 10.1016/j.cca.2017.12.011. PMID: 29229463
Universal predictive criteria for neonatal overt thyrotoxicosis requiring treatment.
Tamaki H, Amino N, Aozasa M, Mori M, Iwatani Y, Tachi J, Nose O, Tanizawa O, Miyai K
Am J Perinatol 1988 Apr;5(2):152-8. doi: 10.1055/s-2007-999676. PMID: 2450549

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